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MAPK signaling cascades

Integrating dynamic modeling of signaling pathways with subject-specific transcriptomic data to assess breast cancer risk

Piyanut Ratphibun Yamashita, Anuwat Tangthanawatsakul, Teerasit Termsaithong, Yaowaluck Maprang Roshorm, Teeraphan Laomettachit

published 13 Aug 2026

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Key targets and mechanisms by which gut microbiota-derived metabolites regulate Alzheimer’s disease through the immune - inflammatory pathway: Based on network pharmacology and molecular docking

Lei Miao, Fengwei Hou, Guanghong Li

published 06 Jul 2026

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Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice

Thammarat Kaewmanee, Palanivel Ganesan, Piyapong Choochana, Pinanong Na-Phatthalung, Samuel Abiodun Kehinde, Sasitorn Chusri

published 26 Jun 2026

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In silico screening and molecular analyses identify apigenin from Scutellaria barbata as a potent AKT1 inhibitor in breast cancer

Md. Maruf Khan, Md. Arju Hossain, Fatematuz Zohora, Md. Sohel, Md. Faisal Amin, Fatematuz Zuhura Evamoni, M. Nazmul Hoque

published 25 Jun 2026

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A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke

Wei-Gang Gong, Jian-Wei Lou, Sen Yin, Fang-Pu Yu, Wei Wu

published 23 Jun 2026

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Differential analysis of Short chain fatty acids incubation in autistic organoids based on transcriptome sequencing

Zaixin Wu, Xinyi Liu, Xiaobo Han, Miao Li

published 05 Jun 2026

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Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability

Marina Pavlova, Irina Shalaginova, Natalia Dyuzhikova

published 03 Jun 2026

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Unraveling dimethylformamide-induced neutrophilic differentiation in HL-60 cells: A proteomic and functional comparison with dimethyl sulfoxide

Othman Eldalal, Yasser Tabana, Dinesh Babu, Newton H. Tran, Steven Lockhart, Joshua Kranrod, John M. Seubert, Lusine Tonoyan, Richard P. Fahlman, Arno G. Siraki

published 13 May 2026

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Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens

Ginte Kutkaite, Göksu Avar, Diyuan Lu, Thomas J. O’Neill, Daniel Krappmann, Michael P. Menden

published 11 May 2026

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IGF1/IGF-1R promotes hepatocellular carcinoma progression by activating the Akt/GSK-3β pathway

Jiaojiao Liang, Xueyi Song, Yang Liu, Guoyu Yang, Bairu Zhu, Xiaolong Tang

published 09 Apr 2026

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Association between chronic stress and the epigenome: Exploration of psychological and biological stress

Melissa Miller, Robin D. Brown, Cole Krautkramer, Rhea Gogia, Hagen Fritz, Dennis Wylie, Kerry Kinney, Frances A. Champagne

published 06 Apr 2026

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Deciphering the synergistic mechanism of a novel flavonoid-antioxidant combination for asthma by combining systems pharmacology and experimental validation

Ziyi Chen, Xinling Ren, Xiaoyu Liu, Lifeng Tian, Yun Huang, Aiping Lyu, Wei Zhou

published 30 Mar 2026

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Systems biology analysis uncovers a ROS-associated gene signature and immunomodulatory role of CLEC4E in ischemic stroke

Lifang Yang, Tianyu Liang, Xiaodi Ding

published 10 Mar 2026

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