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Macromolecular engineering

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning

Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

Directed Evolution of the Transcriptional Regulator DntR: Isolation of Mutants with Improved DNT-Response

Rosa Lönneborg, Edina Varga, Peter Brzezinski

Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution

Hye-Young Sagong, Kyung-Jin Kim

Directed evolution provides insight into conformational substrate sampling by SrtA

Muna Suliman, Vishaka Santosh, [ ... ], William A. Barton

Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F. Garcia-Alles, Katharina Root, [ ... ], Gilles Truan

Programmable In Vivo Selection of Arbitrary DNA Sequences

Tuval Ben Yehezkel, Tamir Biezuner, [ ... ], Ehud Shapiro

Contribution of Disulfide Bridges to the Thermostability of a Type A Feruloyl Esterase from Aspergillus usamii

Xin Yin, Die Hu, [ ... ], Min-Chen Wu

Improving the Thermostability of Acidic Pullulanase from Bacillus naganoensis by Rational Design

Meihui Chang, Xiaoyu Chu, [ ... ], Ningfeng Wu

Deletional Protein Engineering Based on Stable Fold

Govindan Raghunathan, Nagasundarapandian Soundrarajan, [ ... ], Sun-Gu Lee

Desired Alteration of Protein Affinities: Competitive Selection of Protein Variants Using Yeast Signal Transduction Machinery

Misato Kaishima, Nobuo Fukuda, Jun Ishii, Akihiko Kondo

Modeling Analysis of Signal Sensitivity and Specificity by Vibrio fischeri LuxR Variants

Deanna M. Colton, Eric V. Stabb, Stephen J. Hagen

Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling

James T. MacDonald, Lawrence A. Kelley, Paul S. Freemont

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Hidenori Yano, Daisuke Nishimiya, [ ... ], Ryuji Hashimoto

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