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Macromolecular engineering

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning

Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution

Hye-Young Sagong, Kyung-Jin Kim

Programmable In Vivo Selection of Arbitrary DNA Sequences

Tuval Ben Yehezkel, Tamir Biezuner, [ ... ], Ehud Shapiro

Directed evolution provides insight into conformational substrate sampling by SrtA

Muna Suliman, Vishaka Santosh, [ ... ], William A. Barton

Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

Taekyeol Lee, Dongsop Lee, [ ... ], Jaehoon Choi

Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F. Garcia-Alles, Katharina Root, [ ... ], Gilles Truan

Contribution of Disulfide Bridges to the Thermostability of a Type A Feruloyl Esterase from Aspergillus usamii

Xin Yin, Die Hu, [ ... ], Min-Chen Wu

Deletional Protein Engineering Based on Stable Fold

Govindan Raghunathan, Nagasundarapandian Soundrarajan, [ ... ], Sun-Gu Lee

Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling

James T. MacDonald, Lawrence A. Kelley, Paul S. Freemont

Desired Alteration of Protein Affinities: Competitive Selection of Protein Variants Using Yeast Signal Transduction Machinery

Misato Kaishima, Nobuo Fukuda, Jun Ishii, Akihiko Kondo

Modeling Analysis of Signal Sensitivity and Specificity by Vibrio fischeri LuxR Variants

Deanna M. Colton, Eric V. Stabb, Stephen J. Hagen

Improving the Thermostability of Acidic Pullulanase from Bacillus naganoensis by Rational Design

Meihui Chang, Xiaoyu Chu, [ ... ], Ningfeng Wu

Imaging the Directed Transport of Single Engineered RNA Transcripts in Real-Time Using Ratiometric Bimolecular Beacons

Xuemei Zhang, Allison L. Zajac, [ ... ], Andrew Tsourkas

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