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Macromolecular engineering

Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling

James T. MacDonald, Lawrence A. Kelley, Paul S. Freemont

published 18 Jun 2013

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Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana, Yuki Iwayanagi, Futa Mimoto, Yoshinobu Higuchi, Shinya Ishii, Shigero Tamba, Naoka Hironiwa, Kozue Nagano, Tetsuya Wakabayashi, Hiroyuki Tsunoda, Kunihiro Hattori

published 07 May 2013

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Engineering Agatoxin, a Cystine-Knot Peptide from Spider Venom, as a Molecular Probe for In Vivo Tumor Imaging

Sarah J. Moore, Cheuk Lun Leung, Heidi K. Norton, Jennifer R. Cochran

published 03 Apr 2013

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Selection of RNAs for Constructing “Lighting-UP” Biomolecular Switches in Response to Specific Small Molecules

Tamaki Endoh, Naoki Sugimoto

published 26 Mar 2013

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Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Yukiko Okuyama-Nishida, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, Takehisa Kitazawa, Kazutaka Yoshihashi, Aya Harada, Miho Funaki, Kenta Haraya, Tatsuhiko Tachibana, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, Kunihiro Hattori

published 28 Feb 2013

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Probing the Effector and Suppressive Functions of Human T Cell Subsets Using Antigen-Specific Engineered T Cell Receptors

Qi Wan, Lina Kozhaya, Keren Imberg, Frances Mercer, Shi Zhong, Michelle Krogsgaard, Derya Unutmaz

published 20 Feb 2013

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Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking

Luca Simonelli, Mattia Pedotti, Martina Beltramello, Elsa Livoti, Luigi Calzolai, Federica Sallusto, Antonio Lanzavecchia, Luca Varani

published 06 Feb 2013

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A Polypeptide-DNA Hybrid with Selective Linking Capability Applied to Single Molecule Nano-Mechanical Measurements Using Optical Tweezers

Fatemeh Moayed, Alireza Mashaghi, Sander J. Tans

published 15 Jan 2013

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Binding Pocket Optimization by Computational Protein Design

Christoph Malisi, Marcel Schumann, Nora C. Toussaint, Jorge Kageyama, Oliver Kohlbacher, Birte Höcker

published 27 Dec 2012

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Deletional Protein Engineering Based on Stable Fold

Govindan Raghunathan, Nagasundarapandian Soundrarajan, Sriram Sokalingam, Hyungdon Yun, Sun-Gu Lee

published 11 Dec 2012

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Programmable In Vivo Selection of Arbitrary DNA Sequences

Tuval Ben Yehezkel, Tamir Biezuner, Gregory Linshiz, Yair Mazor, Ehud Shapiro

published 14 Nov 2012

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Conjugation of Proteins by Installing BIO-Orthogonally Reactive Groups at Their N-Termini

Nagasundarapandian Soundrarajan, Sriram Sokalingam, Govindan Raghunathan, Nediljko Budisa, Hyun-Jong Paik, Tae Hyeon Yoo, Sun-Gu Lee

published 08 Oct 2012

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Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues

Michelle L. Christian, Zachary L. Demorest, Colby G. Starker, Mark J. Osborn, Michael D. Nyquist, Yong Zhang, Daniel F. Carlson, Philip Bradley, Adam J. Bogdanove, Daniel F. Voytas

published 24 Sep 2012

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