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Macromolecular engineering

Screening of transporters to improve xylodextrin utilization in the yeast Saccharomyces cerevisiae

Chenlu Zhang, Ligia Acosta-Sampson, Vivian Yaci Yu, Jamie H. D. Cate

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard, Gilles Mourier, [ ... ], Denis Servent

Circular Permutation in the Ω-Loop of TEM-1 β-Lactamase Results in Improved Activity and Altered Substrate Specificity

Gurkan Guntas, Manu Kanwar, Marc Ostermeier

How to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit TRAP Suggests a General Mechanism

Chao-Sheng Chen, Callum Smits, [ ... ], Alfred A. Antson

An Automated Flow for Directed Evolution Based on Detection of Promiscuous Scaffolds Using Spatial and Electrostatic Properties of Catalytic Residues

Sandeep Chakraborty

SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity

Derek Cerchione, Katherine Loveluck, [ ... ], Barrett E. Steinberg

Computational prediction of the tolerance to amino-acid deletion in green-fluorescent protein

Eleisha L. Jackson, Stephanie J. Spielman, Claus O. Wilke

Posterior ventral tegmental area-nucleus accumbens shell circuitry modulates response to novelty

Hailong Li, Jessica M. Illenberger, [ ... ], Rosemarie M. Booze

Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology

Roberto Laos, Steven Benner

Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding

David Paramelle, Tao Peng, [ ... ], Nikodem Tomczak

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Allison R. Sirois, Daniela A. Deny, [ ... ], Sarah J. Moore

Directed Evolution of the Transcriptional Regulator DntR: Isolation of Mutants with Improved DNT-Response

Rosa Lönneborg, Edina Varga, Peter Brzezinski

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