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Lysosomes

LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1

Shuangshuang Le, Tongtong Guo, Meng Yang, Tianjuan Tang, Zhijie Liu, Yang Zheng, Maogui Pang

published 15 May 2026

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Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress

David K. Sidibe, Erin M. Smith, Maeve L. Spivey, Maria C. Vogel, Sandra Maday

published 20 Apr 2026

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Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy

Zhuxuan Yan, Wei Chi, Zhenguo Yan, Hanrui Wang

published 07 Apr 2026

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hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A

Youqiang Sun, Mengmeng Liang, Yuemeng Xing, Yifan Duan, Baogui Deng, Xiaobing Xiang

published 03 Apr 2026

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A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis

Emily Clement, Ranime Jebbawi, Abdelouahd Oukhrib, Hélène Labie, Maëlys Le Moal, Séverine Fruchon, Stéphanie Cassel, Anne-Marie Caminade, Cédric-Olivier Turrin, Muriel Blanzat, Michel Simon, Rémy Poupot

published 31 Mar 2026

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Quantitative and temporal analysis of autophagy: Differential Response to amino acid and glucose starvation

Katie R. Martin, Stephanie L. Celano, Jessica D. Guillaume, Ryan D. Sheldon, Russell G. Jones, Jeffrey P. MacKeigan

published 04 Feb 2026

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Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

Akiyoshi Shimoda, Kazuhiro Murai, Hayato Hikita, Satoshi Minami, Takayuki Miyake, Shinji Kuriki, Emi Sometani, Jihyun Sung, Satoshi Shigeno, Yuichiro Higuchi, Kazuki Maesaka, Kumiko Shirai, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Takeshi Takahashi, Hiroshi Suemizu, Tetsuo Takehara

published 16 Jan 2026

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NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants

Nasteho Abdoulkader, Jennifer Archibald, Morgane Lignereux, Eric A. Lehoux, Isabelle Catelas

published 18 Nov 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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KFERQ-selective protein autophagy in Caenorhabditis elegans depends on LMP-1

María Gallardo-Campos, Alicia N. Minniti, Juan Hormazabal, Gonzalo Núñez, Carlos F. Lagos, Tomás Perez-Acle, Rebeca Aldunate, Iván E. Alfaro

published 02 Sep 2025

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Identification of the Francisella novicida FTN_0096 as a factor involved in intracellular replication and host response

Dhandy Koesoemo Wardhana, Takashi Shimizu, Kenta Watanabe, Akihiko Uda, Masahisa Watarai

published 01 Aug 2025

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Recombinant human alpha-N-acetylglucosamine-6-sulfatase delivered to Sanfilippo D mice with repeated intracerebroventricular injections corrects CNS pathology

Grant L. Austin, Feng Wang, Steven Q. Le, Alexander Sorensen, Shan Li, Lai C. Foong, Srikanth Singamsetty, Jill Wood, Tsui-Fen Chou, Patricia I. Dickson

published 25 Jul 2025

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Multi-omics analysis and single-cell sequencing revealed the lysosome associated molecular subtypes and prognostic model development of papillary thyroid carcinoma

Jianhua Zhang, Kai Yue, Yansheng Wu, Chao Jing, Xudong Wang

published 10 Jun 2025

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