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Lysosomes

Quantitative and temporal analysis of autophagy: Differential Response to amino acid and glucose starvation

Katie R. Martin, Stephanie L. Celano, Jessica D. Guillaume, Ryan D. Sheldon, Russell G. Jones, Jeffrey P. MacKeigan

published 04 Feb 2026

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Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

Akiyoshi Shimoda, Kazuhiro Murai, Hayato Hikita, Satoshi Minami, Takayuki Miyake, Shinji Kuriki, Emi Sometani, Jihyun Sung, Satoshi Shigeno, Yuichiro Higuchi, Kazuki Maesaka, Kumiko Shirai, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Takeshi Takahashi, Hiroshi Suemizu, Tetsuo Takehara

published 16 Jan 2026

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NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants

Nasteho Abdoulkader, Jennifer Archibald, Morgane Lignereux, Eric A. Lehoux, Isabelle Catelas

published 18 Nov 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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KFERQ-selective protein autophagy in Caenorhabditis elegans depends on LMP-1

María Gallardo-Campos, Alicia N. Minniti, Juan Hormazabal, Gonzalo Núñez, Carlos F. Lagos, Tomás Perez-Acle, Rebeca Aldunate, Iván E. Alfaro

published 02 Sep 2025

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Identification of the Francisella novicida FTN_0096 as a factor involved in intracellular replication and host response

Dhandy Koesoemo Wardhana, Takashi Shimizu, Kenta Watanabe, Akihiko Uda, Masahisa Watarai

published 01 Aug 2025

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Recombinant human alpha-N-acetylglucosamine-6-sulfatase delivered to Sanfilippo D mice with repeated intracerebroventricular injections corrects CNS pathology

Grant L. Austin, Feng Wang, Steven Q. Le, Alexander Sorensen, Shan Li, Lai C. Foong, Srikanth Singamsetty, Jill Wood, Tsui-Fen Chou, Patricia I. Dickson

published 25 Jul 2025

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Multi-omics analysis and single-cell sequencing revealed the lysosome associated molecular subtypes and prognostic model development of papillary thyroid carcinoma

Jianhua Zhang, Kai Yue, Yansheng Wu, Chao Jing, Xudong Wang

published 10 Jun 2025

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Autophagy across tissues of aging mice

Julian M. Carosi, Alexis Martin, Leanne K. Hein, Sofia Hassiotis, Kathryn J. Hattersley, Bradley J. Turner, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant

published 04 Jun 2025

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AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, Mugdha Deshpande, Shin-ichi Matsumoto, Miyu Nakayama, Syunsuke Yamamoto, Bettina Strack-Logue, Takeshi Hioki, Maiko Tanaka, Gabriele Proetzel

published 07 May 2025

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Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition

Jinghui Zhang, Xusheng Chang, Yingcheng Bai, Xiancai Ge, Kai Yin, Qun Xin

published 02 May 2025

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Chemigenetic Ca²⁺ indicators report elevated Ca²⁺ levels in endothelial Weibel-Palade bodies

Julian Terglane, Nicole Mertes, Sarah Weischer, Thomas Zobel, Kai Johnsson, Volker Gerke

published 27 Jan 2025

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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B. Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E. Crawford, Stuart Bunting, Mika Aoyagi-Scharber

published 03 Jan 2025

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