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Lysosomes

A Critical Tryptophan and Ca²⁺ in Activation and Catalysis of TPPI, the Enzyme Deficient in Classic Late-Infantile Neuronal Ceroid Lipofuscinosis

Salomon Kuizon, Kathleen DiMaiuta, [ ... ], Mohammed A. Junaid

Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations

Nathanael McCurley, Ira Mellman

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

Rodrigo A. Fuentealba, Qiang Liu, [ ... ], Guojun Bu

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Kristiina Rajamäki, Jani Lappalainen, [ ... ], Kari K. Eklund

Identification of Roles for Peptide: N-Glycanase and Endo-β-N-Acetylglucosaminidase (Engase1p) during Protein N-Glycosylation in Human HepG2 Cells

Isabelle Chantret, Magali Fasseu, [ ... ], Stuart E. H. Moore

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

Karin Forsberg, P. Andreas Jonsson, [ ... ], Thomas Brännström

Host Factors Required for Modulation of Phagosome Biogenesis and Proliferation of Francisella tularensis within the Cytosol

Christine Akimana, Souhaila Al-Khodor, Yousef Abu Kwaik

Immunoregulatory Actions of Epithelial Cell PPAR γ at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease

Saroj K. Mohapatra, Amir J. Guri, [ ... ], Josep Bassaganya-Riera

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

Chew Hooi Wong, Kartini Bte Iskandar, [ ... ], Shazib Pervaiz

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

Belen Tizon, Susmita Sahoo, [ ... ], Efrat Levy

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

Guido Krebiehl, Sabine Ruckerbauer, [ ... ], Rejko Krüger

Dysbindin Promotes the Post-Endocytic Sorting of G Protein-Coupled Receptors to Lysosomes

Aaron Marley, Mark von Zastrow

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

Leslie Crews, Brian Spencer, [ ... ], Eliezer Masliah

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