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Inflammasomes

Human resistin is critical to activation of the NLRP3 inflammasome in macrophages

Udeshika Kariyawasam, Winson Lam, John Skinner, Rituparna Chakrabarti, Andrea Cox, Paul M. Hassoun, Qing Lin, Roger A. Johns

published 10 Apr 2026

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GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis

Yu Sun, Jiahui Wei, Yanjun Zhao, Xingbo Jiang, Chao He, Xianhui Huang, Fengying Lei, Yuanhan Qin

published 19 Mar 2026

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Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome

Menglong Feng, Xiaoqing Zhou, Ting Yang, Zhiji Chen, Guijun Yang, Xu Jiang, Wei Yuan

published 09 Mar 2026

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The effects of high-intensity interval training on NLRP3 inflammasome and monocyte chemokine receptors in individuals with obesity

Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Lucas Melo Neves, Saulo Gil, Fernando Mateus Santos, Jefferson Russo Victor, Marina Tiemi Shio, Carolina Nunes França

published 23 Feb 2026

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A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability

Qian Deng, Qianqian Bai, Yang Yang, Wenchao Tang, Fangfei Liu, Shumin Zhang, Hao Wang, Zhehua Xing, Chi Zhang, Yanhui Yang, Qizhi Fu, Hua Fan

published 20 Feb 2026

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Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury

Xuehu Zhang, Aoqin Gu, Lirong Zhou, Yuru Ma, Peng Wu, Baozhen Zhu, Ru Yan, Guangzhi Cong, Xueping Ma, Shaobin Jia

published 06 Feb 2026

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The KEAP1/NRF2 axis controls LPS-induced oxidative stress, inflammasome activation and caspase-1 activity in human endothelial cells

Alba Montero-Jodra, Maria Jesús Estebán-Amo, Silvia Patricia Fernández-Martínez, César García Martínez, Miguel Ángel de la Fuente García, Adrián García-Concejo, Marta Martín-Fernández, Eduardo Tamayo, María Simarro

published 04 Feb 2026

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Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls

Seyed Alireza Mirjalili, Seyed Mehdi Kalantar, Fateme Montazeri, Reyhaneh Azizi, Elham Hosseini, Fateme Zare, Samira Asgharzade, Korosh Ashrafi Dehkordi

published 18 Dec 2025

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Evogliptin prevents ceramide-induced pyroptosis during calcification via modulation of NLRP3/GSDM-D mediated pathway in Vascular Smooth Muscle Cells

Razia Rashid Rahil, Salman Shamas, Nissar Ahmad Wani, Neha Nanda, Sheikh Fayaz Ahmad, Sabry Mohamed Attia, Abid Hamid, Mohammad Afzal Zargar, Owais Mohmad Bhat

published 03 Dec 2025

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The role and mechanism of irisin/NLRP3 signal in aerobic exercise ameliorating blood glucose homeostasis in pre-diabetic mice

Shujuan Hu, Zhengkang Wu, Xuan Liu, Yiting Ding, Jun Chen, Xianwang Wang

published 20 Nov 2025

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NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants

Nasteho Abdoulkader, Jennifer Archibald, Morgane Lignereux, Eric A. Lehoux, Isabelle Catelas

published 18 Nov 2025

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β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE^−/− mice

Weiping Wu, Wugao Liu, Ningjun Wu, Chunsheng Qu, Weihua Chu, Jing Jin

published 18 Sep 2025

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CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells

Jingtong Xiong, Shuo Li, Honghai Chen, Chuanwen Yu, Yuhai Cao, Xiaofeng Qu, Jianlin Wu, Aodan Zhang, Chuang Sun

published 18 Sep 2025

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