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Inflammasomes

A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability

Qian Deng, Qianqian Bai, Yang Yang, Wenchao Tang, Fangfei Liu, Shumin Zhang, Hao Wang, Zhehua Xing, Chi Zhang, Yanhui Yang, Qizhi Fu, Hua Fan

published 20 Feb 2026

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Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury

Xuehu Zhang, Aoqin Gu, Lirong Zhou, Yuru Ma, Peng Wu, Baozhen Zhu, Ru Yan, Guangzhi Cong, Xueping Ma, Shaobin Jia

published 06 Feb 2026

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The KEAP1/NRF2 axis controls LPS-induced oxidative stress, inflammasome activation and caspase-1 activity in human endothelial cells

Alba Montero-Jodra, Maria Jesús Estebán-Amo, Silvia Patricia Fernández-Martínez, César García Martínez, Miguel Ángel de la Fuente García, Adrián García-Concejo, Marta Martín-Fernández, Eduardo Tamayo, María Simarro

published 04 Feb 2026

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Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls

Seyed Alireza Mirjalili, Seyed Mehdi Kalantar, Fateme Montazeri, Reyhaneh Azizi, Elham Hosseini, Fateme Zare, Samira Asgharzade, Korosh Ashrafi Dehkordi

published 18 Dec 2025

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Evogliptin prevents ceramide-induced pyroptosis during calcification via modulation of NLRP3/GSDM-D mediated pathway in Vascular Smooth Muscle Cells

Razia Rashid Rahil, Salman Shamas, Nissar Ahmad Wani, Neha Nanda, Sheikh Fayaz Ahmad, Sabry Mohamed Attia, Abid Hamid, Mohammad Afzal Zargar, Owais Mohmad Bhat

published 03 Dec 2025

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The role and mechanism of irisin/NLRP3 signal in aerobic exercise ameliorating blood glucose homeostasis in pre-diabetic mice

Shujuan Hu, Zhengkang Wu, Xuan Liu, Yiting Ding, Jun Chen, Xianwang Wang

published 20 Nov 2025

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NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants

Nasteho Abdoulkader, Jennifer Archibald, Morgane Lignereux, Eric A. Lehoux, Isabelle Catelas

published 18 Nov 2025

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β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE^−/− mice

Weiping Wu, Wugao Liu, Ningjun Wu, Chunsheng Qu, Weihua Chu, Jing Jin

published 18 Sep 2025

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CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells

Jingtong Xiong, Shuo Li, Honghai Chen, Chuanwen Yu, Yuhai Cao, Xiaofeng Qu, Jianlin Wu, Aodan Zhang, Chuang Sun

published 18 Sep 2025

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LBH589 reduces oxidized mitochondrial DNA and suppresses NLRP3 inflammasome activation to relieve pulmonary inflammation

Changwen Ning, Fenghua Gao, Zhe Wang, Huaying An, Pengyu Liu, Yanan Sun, Ru Li, Zhuyang Song, Yuanyuan Yuan, Jinlong Li, Jun Ma, Xingwei Jiang, Qun Yu

published 04 Aug 2025

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Role of rosuvastatin and pitavastatin in alleviating diabetic cardiomyopathy in rats: Targeting of RISK, NF-κB/ NLRP3 inflammasome and TLR4/ NF-κB signaling cascades

Dalia O. Saleh, Nesma M.E. Abo El Nasr, Marawan A. Elbaset, Marwa E. Shabana, Tuba Esatbeyoglu, Sherif M. Afifi, Ingy M. Hashad

published 30 Jul 2025

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Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6

Marianna Onori, Giuliana Beneduce, Filomena Colella, Donatella Lucchetti, Caterina Policola, Vincenzo Arena, Fabio Sannino, Alessandro Petrecca, Dario Pitocco, Alfredo Pontecorvi, Alessandro Sgambato, Giovanni Scambia, Nicoletta Di Simone, Tullio Ghi, Chiara Tersigni

published 17 Jun 2025

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Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway

Yu Wang, Chaofan Chen, Yushan Li, Ran Li, Jinghan Wang, Chao Wu, Haonan Chen, Yingchao Shi, Shengfang Wang, Chuanyu Gao

published 06 Jun 2025

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