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Hepatocytes

Multi-omics analysis identifies PPARα as a key inhibitor of hepatocyte ferroptosis in sepsis-associated liver injury

Shi-Ling He, Jian-Chuan Lin, Gao-Fang Wu, He-fan He

published 19 Feb 2026

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GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells

Sini M. Kinnunen, Katja Eloranta, Marjut Pihlajoki, Mika J. Välimäki, Saana Pohjavaara, Emilie Indersie, Stefano Cairo, Aarni Kuusinen, Heikki Ruskoaho, Markku Heikinheimo

published 11 Feb 2026

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Assessment of antidiabetic, hepatoprotective, and analgesic effects of quinazolinone derivative, (E)-1-Benzoyl-3-((4- (Dimethylamino) Benzylidene) Amino)-2-(4-(Dimethylamino) Phenyl)-2,3 dihydroquinazoline-4(1h)-one, in diabetes induced mice model

Haider Ali, Asif Jan, Gowhar Ali, Syed Shaukat Ali, Abdur Rahim, Ursula Abu Nahla

published 04 Feb 2026

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Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition

Myrian Velasco, Rosa Isela Ortiz-Huidobro, Ana María Salazar, Marcia Hiriart, Patricia Ostrosky-Wegman, Pablo Pánico

published 30 Dec 2025

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Diet-induced steatohepatitis does not cause heart failure with preserved ejection fraction in male middle-aged C57BL/6N mice

Chase W. Kessinger, Lin Chen, Felicia Huang, Jierui Lin, Amanda Davenport, Zhiqiang Lin

published 29 Dec 2025

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity

Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada, Shinpei Yamaguchi

published 29 Dec 2025

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Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways

Hilde Sundvold, Thea Bismo Strøm

published 04 Dec 2025

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Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease

J. Jose Corbalan, Pranavi Jagadeesan, Joseph T. Nickels Jr

published 15 Oct 2025

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Frizzled 7 drives amplification of cancer stem-cell subpopulations and the aggressiveness and poor differentiation of human hepatocellular carcinoma

Anaïs Lopez, Alexia Paturel, Nadim Fares, Floriane Pez, Guanxiong Wang, Patricia Gifu, Lydie Lefrançois, Jihed Chouaref, Pierre Saintigny, Janick Selves, Jean-Marie Peron, Michel Rivoire, Philippe Merle, Claude Caron de Fromentel

published 07 Oct 2025

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Gardenia jasminoides fruit extract ameliorates non-alcoholic steatohepatitis with fibrosis by modulating inflammatory and fibrogenic pathways

Natnicha Suttawong, Namthip Witayavanitkul, Maneerat Chayanupatkul, Natcha Wanpiyarat, Pornpen Werawatganone, Prasong Siriviriyakul, Duangporn Werawatganon

published 03 Oct 2025

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A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy

Meiyuan Tian, Yaogang Zhang, Zhe Liu, Na Zhao, Dengliang Huang, Jing Hou, Li Sun, Yuan Jiang, Guangcun Zhang, Yanyan Ma

published 25 Sep 2025

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Deciphering the role of the lncRNA TRIBAL in hepatocyte models

Sébastien Soubeyrand, Paulina Lau, Ruth McPherson

published 02 Sep 2025

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Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis

Shan Zhang, Shasha Hu, Haibo Tan, Ertao Jia

published 06 Aug 2025

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