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Hepatocytes

PPARγ-dependent and -independent regulation of genes involved in hepatic methionine cycle in fasted or diet-induced obese mice

Izabela Hawro, Samuel M. Lee, Rhonda D. Kineman, Jose Cordoba-Chacon

published 18 Sep 2026

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Environmental PFOA exposure and the risk of metabolic dysfunction-associated steatotic liver disease: An integrated computational toxicology and multi-omics study

Tianyu Zhang, Yu Yuan, Chunli Lin, Chao Song, Tianrong Liao, Yuewen Sun, Hongzhen Tang

published 09 Sep 2026

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hLMR1, a hepatocyte-specific long noncoding RNA that represses amino acid catabolism through pre-mRNA interaction in human liver

Marcos E. Jaso-Vera, Shohei Takaoka, Lanuza A.P. Faccioli, Zhiping Hu, Alejandro Soto-Gutierrez, Xiangbo Ruan

published 21 Jul 2026

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Multi-omics analysis identifies PPARα as a key inhibitor of hepatocyte ferroptosis in sepsis-associated liver injury

Shi-Ling He, Jian-Chuan Lin, Gao-Fang Wu, He-fan He

published 19 Feb 2026

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GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells

Sini M. Kinnunen, Katja Eloranta, Marjut Pihlajoki, Mika J. Välimäki, Saana Pohjavaara, Emilie Indersie, Stefano Cairo, Aarni Kuusinen, Heikki Ruskoaho, Markku Heikinheimo

published 11 Feb 2026

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Assessment of antidiabetic, hepatoprotective, and analgesic effects of quinazolinone derivative, (E)-1-Benzoyl-3-((4- (Dimethylamino) Benzylidene) Amino)-2-(4-(Dimethylamino) Phenyl)-2,3 dihydroquinazoline-4(1h)-one, in diabetes induced mice model

Haider Ali, Asif Jan, Gowhar Ali, Syed Shaukat Ali, Abdur Rahim, Ursula Abu Nahla

published 04 Feb 2026

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Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition

Myrian Velasco, Rosa Isela Ortiz-Huidobro, Ana María Salazar, Marcia Hiriart, Patricia Ostrosky-Wegman, Pablo Pánico

published 30 Dec 2025

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Diet-induced steatohepatitis does not cause heart failure with preserved ejection fraction in male middle-aged C57BL/6N mice

Chase W. Kessinger, Lin Chen, Felicia Huang, Jierui Lin, Amanda Davenport, Zhiqiang Lin

published 29 Dec 2025

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity

Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada, Shinpei Yamaguchi

published 29 Dec 2025

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Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways

Hilde Sundvold, Thea Bismo Strøm

published 04 Dec 2025

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Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease

J. Jose Corbalan, Pranavi Jagadeesan, Joseph T. Nickels Jr

published 15 Oct 2025

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Frizzled 7 drives amplification of cancer stem-cell subpopulations and the aggressiveness and poor differentiation of human hepatocellular carcinoma

Anaïs Lopez, Alexia Paturel, Nadim Fares, Floriane Pez, Guanxiong Wang, Patricia Gifu, Lydie Lefrançois, Jihed Chouaref, Pierre Saintigny, Janick Selves, Jean-Marie Peron, Michel Rivoire, Philippe Merle, Claude Caron de Fromentel

published 07 Oct 2025

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Gardenia jasminoides fruit extract ameliorates non-alcoholic steatohepatitis with fibrosis by modulating inflammatory and fibrogenic pathways

Natnicha Suttawong, Namthip Witayavanitkul, Maneerat Chayanupatkul, Natcha Wanpiyarat, Pornpen Werawatganone, Prasong Siriviriyakul, Duangporn Werawatganon

published 03 Oct 2025

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