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Guide RNA

Functional role of THRAP3 in modulating thyroid hormone–mediated gene networks in C2C12 myotubes

Taku Fukushima, Sachi Kuse, Yuka Hasegawa, Taiju Fujioka, Takeshi Nikawa, Satoru Masubuchi, Iori Sakakibara

published 22 Jan 2026

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Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology

Claire Verkuyl, Ari Belotserkovsky, Thomas Zerbes, Declan Williams, Medha R. Krishnan, Sabrina Zhu, Sophie Grunnesjӧ, Shehab Eid, Cunjie Zhang, Wenda Zhao, Leo Xu, Eleanore Lin, Teaghan O’Shea, Benjamin Draper, Andreas Jungman, Patrick Most, Gerold Schmitt-Ulms

published 07 Nov 2025

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Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2

Tom A. W. Schoufour, Linda Voogd, Kees L.M.C. Franken, Tom H.M. Ottenhoff, Ruud H.M. Wijdeven, Simone A. Joosten

published 13 Oct 2025

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Targeting the Exon2 splice cis-element in PD-1 and its effects on lymphocyte function

Yuto Tan, Naoko Kumagai-Takei, Yurika Shimizu, Akira Yamasaki, Mari Hara-Yamamoto, Shigeru Mitani, Tatsuo Ito

published 08 Sep 2025

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CRISPR-Cas9 targeting the bla_KPC gene in a clinical isolate of Klebsiella michiganensis: Reduction of imipenem resistance and changes in genomic carbapenem resistance determinants

Thaysa Leite Tagliaferri, Alex Krüttgen, Tiago Antônio de Oliveira Mendes, Simone Gonçalves dos Santos, Hans-Peter Horz

published 12 Aug 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines

Spencer C. Wei, Aaron J. Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Ashil Bans, Prachi Khekare, Suhani Gupta, Jonathan Wang, Craig Soares, Radwan Kiwan, Jieun Lee, Shannon McCawley, Vihasi Jani, Weng In Leong, Pawan K. Shahi, Jean Chan, Pierre Boivin, Peter Otoupal, Bikash R. Pattnaik, David M. Gamm, Krishanu Saha, Benjamin G. Gowen, Mary Haak-Frendscho, Mary J. Janatpour, Adam P. Silverman

published 24 Jun 2025

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A simple validation and screening method for CRISPR/Cas9-mediated gene editing in mouse embryos to facilitate genetically modified mice production

Dawid Winiarczyk, Hossein Khodadadi, Paweł Leszczyński, Hiroaki Taniguchi

published 27 Mar 2025

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Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR

Benjamin G. Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J. Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J. Janatpour, Spencer C. Wei

published 24 Feb 2025

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DAPE cloning with modified primers for producing designated lengths of 3’ single-stranded ends in PCR products

Seoee Lee, Hyunyoung Kim, Aqsa, Kwangjin Jeung, Minho Won, Hyunju Ro

published 13 Feb 2025

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Evidence for gene essentiality in Leishmania using CRISPR

Wen-Wei Zhang, Greg Matlashewski

published 30 Dec 2024

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Development of an optimized protocol for generating knockout cancer cell lines using the CRISPR/Cas9 system, with emphasis on transient transfection

Seyed Alireza Mousavi Kahaki, Nayereh Ebrahimzadeh, Hossein Fahimi, Arfa Moshiri

published 14 Nov 2024

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Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells

Rachel B. Gilmore, Dea Gorka, Christopher E. Stoddard, Pooja Sonawane, Justin Cotney, Stormy J. Chamberlain

published 01 Nov 2024

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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Tom Cremer, Hanneke Hoelen, Michael L. van de Weijer, George M. Janssen, Ana I. Costa, Peter A. van Veelen, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz

published 24 May 2024

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