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Guanine nucleotide exchange factors

Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines

Mohamed El-Tanani, Shakta Mani Satyam, [ ... ], Frezah Muhana

Impact of substrate choice on human osteoclast differentiation and secretome: Implications for targeted therapeutic development

Fernanda D’Amélio, Hugo Vigerelli, [ ... ], Irina Kerkis

Mapping spatiotemporal distribution of forest carbon density in Xizang, China

Li Cheng, Zi ling Yang, [ ... ], Jiang ping Fang

3-O-acetylrubiarbonol B preferentially targets EGFR and MET over rubiarbonol B to inhibit NSCLC cell growth

A-Young Nam, Sang Hoon Joo, [ ... ], Jung-Hyun Shim

Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development

Theresa A. Reimels, Mia Steinberg, [ ... ], Cathie M. Pfleger

A comparative analysis of attitudes toward genome-edited food among Japanese public and scientific community

Ryuma Shineha, Kohei F. Takeda, Yube Yamaguchi, Nozomu Koizumi

Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity

Eric M. Rosenberg Jr., Xiaoying Jian, [ ... ], Paul A. Randazzo

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

Daniel Koch, Ay Lin Kho, [ ... ], Mathias Gautel

Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study

Kang Li, Haiquan Wang, [ ... ], Jiankui Zhou

Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

Shintaro Saegusa, Masahiro Fukaya, [ ... ], Hiroyuki Sakagami

A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature

Christine N. Daniels, Trevin R. Zyla, Daniel J. Lew

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization

Lucas J. M. Bruurs, Mirjam C. van der Net, [ ... ], Johannes L. Bos

Comparison of cardiac function index derived from femoral and jugular indicator injection for transpulmonary thermodilution with the PiCCO-device: A prospective observational study

Alexander Herner, Markus Heilmaier, [ ... ], Wolfgang Huber

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