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Genetically modified organisms

FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans

Ingrid Buntschuh, Daniel A. Raps, Ivor Joseph, Christopher Reid, Alexander Chait, Raubern Totanes, Michelle Sawh, Chris Li

published 02 Jan 2018

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Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2

Miki Shimbo, Riku Suzuki, Sayaka Fuseya, Takashi Sato, Katsue Kiyohara, Kozue Hagiwara, Risa Okada, Hiromasa Wakui, Yuki Tsunakawa, Hideto Watanabe, Koji Kimata, Hisashi Narimatsu, Takashi Kudo, Satoru Takahashi

published 29 Dec 2017

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Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and –independent signaling

Li Liu, Jena J. Steinle

published 29 Dec 2017

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Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease

Wenbo Zhou, Jessica Cummiskey Barkow, Curt R. Freed

published 22 Dec 2017

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Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis

Veronika Bäcker, Fung-Yi Cheung, Jens T. Siveke, Joachim Fandrey, Sandra Winning

published 20 Dec 2017

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Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise

Jakob G. Knudsen, Anders Gudiksen, Lærke Bertholdt, Peter Overby, Ida Villesen, Camilla L. Schwartz, Henriette Pilegaard

published 18 Dec 2017

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Formation of large viroplasms and virulence of Cauliflower mosaic virus in turnip plants depend on the N-terminal EKI sequence of viral protein TAV

Angèle Geldreich, Gabrielle Haas, Julie Kubina, Clément Bouton, Mélanie Tanguy, Mathieu Erhardt, Mario Keller, Lyubov Ryabova, Maria Dimitrova

published 18 Dec 2017

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Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

Lídia Cedó, David Santos, Núria Roglans, Josep Julve, Victor Pallarès, Andrea Rivas-Urbina, Vicenta Llorente-Cortes, Joan Carles Laguna, Francisco Blanco-Vaca, Joan Carles Escolà-Gil

published 15 Dec 2017

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FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation

Gewei Lian, Sneha Kanaujia, Timothy Wong, Volney Sheen

published 14 Dec 2017

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N-acetylcysteine (NAC) ameliorates Epstein-Barr virus latent membrane protein 1 induced chronic inflammation

Xiao Gao, Eirini-Maria Lampraki, Sarwah Al-Khalidi, Muhammad Asif Qureshi, Rhea Desai, Joanna Beatrice Wilson

published 11 Dec 2017

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Generation and phenotypic characterisation of a cytochrome P450 4x1 knockout mouse

Himanshu Kharkwal, Farhat Batool, Frank Koentgen, David R. Bell, David A. Kendall, Francis J. P. Ebling, Ian R. Duce

published 11 Dec 2017

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Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice

Sabina Eigenbrod, Petra Frick, Uwe Bertsch, Gerda Mitteregger-Kretzschmar, Janina Mielke, Marko Maringer, Niklas Piening, Alexander Hepp, Nathalie Daude, Otto Windl, Johannes Levin, Armin Giese, Vignesh Sakthivelu, Jörg Tatzelt, Hans Kretzschmar, David Westaway

published 08 Dec 2017

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Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model

Austin Ferro, Emily Carbone, Jenny Zhang, Evan Marzouk, Monica Villegas, Asher Siegel, Donna Nguyen, Thomas Possidente, Jessilyn Hartman, Kailen Polley, Melissa A. Ingram, Georgia Berry, Thomas H. Reynolds, Bernard Possidente, Kimberley Frederick, Stephen Ives, Sarita Lagalwar

published 06 Dec 2017

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