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Genetically modified organisms

Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen

published 20 Apr 2026

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Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron DiAntonio

published 17 Apr 2026

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Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation

Mariana Moraes de Lima Perini, Alyssa F. Fayemi, Julie N. Pugh, Elizabeth M. Scott, Karan Bhula, Austin Chirgwin, Olivia N. White, Nicolas F. Berbari, Jiliang Li

published 02 Apr 2026

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A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features

Jean-Pierre Bayley, Heggert G. Rebel, Peter Devilee

published 31 Mar 2026

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The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m⁶A RNA modification

Hang Sun, Haozhi Xu, Junying Li, Xiaoman Xie, Junmei Zhang, Hongjie Dong, Huanhuan Xie, Qi Wang, Guihua Zhao, Kun Yin, Jingyu Yang, Jianwei Zhou, Ruili Wu, Chao Xu

published 24 Mar 2026

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Food and feed safety of a novel Vip3C insecticidal protein derived from Paenibacillus spp. for protection of crop plants against key Lepidopteran pests

Lucas J. McKinnon, Rong Wang, Cunxi Wang, Scott Saracco, Colton Kessenich, Virginia M. Johnson, Jennifer Calcaterra, Gregory Frierdich, Eric Bretsnyder, Luting Fang, Bingyao Li, Tianbo Xu

published 18 Mar 2026

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Age-associated accumulation of carbamylation-derived products in tissues is independent from the myeloperoxidase pathway in mice

Christine Pietrement, Anaïs Okwieka, Lucile Cadoret, Manon Doué, Philippe Gillery, Stéphane Jaisson

published 16 Mar 2026

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Choosing the best route: Comparative optimization of wheat transformation methods for improving yield by targeting TaARE1-D with CRISPR/Cas9

Mumin Ibrahim Tek, Kubra Budak Tek, Pelin Sarikaya, Abdul Razak Ahmed, Hakan Fidan

published 09 Feb 2026

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Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice

Alyona E. Bannikova, Tatiana S. Pronina, Dmitry V. Troshev, Vsevolod V. Bogdanov, Anna A. Kolacheva, Ekaterina N. Pavlova, Victor E. Blokhin, Varvara I. Kalashnikova, Michael V. Ugrumov

published 06 Feb 2026

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Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease

Kiana L. Chen, Stacey Duemmel, Michael Christof, Gaochan Wang, H. Mark Kenney, Marc Nuzzo, Qingfu Xu, Benjamin Korman, Homaira Rahimi

published 05 Feb 2026

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Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment

Xiaomei Wang, Yuanmin Qi, Ziming Zhu, Caiqin Wang, Zhimin Zhang, Haocheng Jia, Linhui Xia, Kai Meng, Jinxiang Yuan

published 30 Jan 2026

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PFKFB3 exacerbates myocardial injury by accelerating CXCR4^hi neutrophil mobilization after acute myocardial infarction

Yingjia Xu, Min Xiao, Qin Zhu, Wutao Wang, Danrui Wang, Dadong Liu, Zongying Yu

published 29 Jan 2026

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Monitoring of Cd and GSH contents and Bn-OASTL expression in transgenic tobacco seedlings in response to Cd stress

Xiaolan He, Jianwei Wang, Wenxu Li, Xinhong Chen

published 22 Jan 2026

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