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Genetically modified animals

Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice

Alyona E. Bannikova, Tatiana S. Pronina, Dmitry V. Troshev, Vsevolod V. Bogdanov, Anna A. Kolacheva, Ekaterina N. Pavlova, Victor E. Blokhin, Varvara I. Kalashnikova, Michael V. Ugrumov

published 06 Feb 2026

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Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease

Kiana L. Chen, Stacey Duemmel, Michael Christof, Gaochan Wang, H. Mark Kenney, Marc Nuzzo, Qingfu Xu, Benjamin Korman, Homaira Rahimi

published 05 Feb 2026

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Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment

Xiaomei Wang, Yuanmin Qi, Ziming Zhu, Caiqin Wang, Zhimin Zhang, Haocheng Jia, Linhui Xia, Kai Meng, Jinxiang Yuan

published 30 Jan 2026

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PFKFB3 exacerbates myocardial injury by accelerating CXCR4^hi neutrophil mobilization after acute myocardial infarction

Yingjia Xu, Min Xiao, Qin Zhu, Wutao Wang, Danrui Wang, Dadong Liu, Zongying Yu

published 29 Jan 2026

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Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium

Shannon K. Harkins, Hilary J. Skalski, Abigail Z. Bennett, Laura A. Pavliscak, Nakati C. Sany, Amelia R. Arendt, Lauren Wood, Genna E. Moldovan, Ronald L. Chandler

published 19 Dec 2025

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Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice

Julie Rose Hens, Stacey Brown, Pawel Licznerski, Jacqueline Suarez, Elizabeth Jonas, John J. Wysolmerski

published 15 Dec 2025

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UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury

Dongliang Liu, Yudong Liu, Tianding Wu, Jianzhong Hu

published 12 Dec 2025

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Conditional deletion of Tmem63b does not impact mouse voiding behavior

Marianela G. Dalghi, Wily G. Ruiz, Dennis R. Clayton, Tanmay Parakala-Jain, Marcelo D. Carattino, Yun Stone Shi, Gerard Apodaca

published 05 Dec 2025

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Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, Sonia Bustamante, Krishan Gondal, Peggy Rentsch, Gayathri Sundaram, Michael D. Lovelace, Bryce Vissel, Bruce J. Brew

published 04 Dec 2025

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Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch

Joao M. Braz, Madison Jewell, Karnika Bhardwaj, Sian Rodriguez-Rosado, Veronica Craik, Allan I. Basbaum

published 02 Dec 2025

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Dysbiosis of gut microbiota in C57BL/6-Lep^em1hwl/Korl mice during microplastics-caused hepatic metabolism disruption

Yu Sang Choi, Yu Jeong Roh, Ji Eun Kim, Hee Jin Song, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ji Eun Sung, Ye Eun Ryu, Ye Ryeong Kim, Hyun Su Park, Hong Joo Son, Yu Jin Kim, Eun Sang Jung, Sunho Park, Dae Youn Hwang

published 20 Nov 2025

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UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans

Tomoko Onishi, Hajime Okayama, Hitomi Kitano, Katsuaki Higashi, Naoki Nakagawa, Motohiro Nonaka, Shogo Oka, Jyoji Morise

published 13 Nov 2025

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Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model

Meaghan Navarrete-Mathews, Gloria S. Lee, Angel Walerio, Dylan Horne, Yuying Wu, Yi Zhou

published 11 Nov 2025

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