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Genetically modified animals

SIRT5 deficiency exacerbates sepsis acute renal injury by activating ACSL4/FTH1 axis dependent ferroptosis

Liliang Jiang, Xi Yu, Guang Shan, Ziqi He, Yongbo Liu, Wenlong Lin, Lingling Song, Zhongyuan Xia

published 27 Oct 2026

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No phenotypes in Ttc22 knockout mice

Jiaoyang Liu, Liankun Gu, Abin You, Hongfan Yuan, Jing Zhou, Wei Tian, Dajun Deng

published 23 Oct 2026

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Smooth muscle cell mineralocorticoid receptor does not contribute to atherosclerosis in male or female ApoE-knockout mice

Nicole L. Svedberg, Wenxi An, Sorelle Tan, Iris Z. Jaffe

published 15 Oct 2026

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Lethal Sudan virus infection in IFNAR^-/- mice is characterized by key inflammatory features of filovirus disease

Michelle Gellhorn Serra, Cornelius Rohde, Lucie Sauerhering, Lars Meier, Lennart Kämper, Pauline Neubecker, Markus Eickmann, Alexandra Kupke, Stephan Becker, Anke-Dorothee Werner

published 29 Sep 2026

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Sex-based differences in the gut-metabolism axis in aging and Nrf2-deficient mice

Si Yang, Jiayi Zhou, Yuhan Yang, Pei Xu, Bolan Yu

published 21 Sep 2026

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Identification of Galectin-9 (Gal-9) as a B7-H4 binding partner and characterization of their glycosylation-dependent interaction that modulates T cell signaling within a multi-ligand/receptor network

Ravear Zhiqiang Wang, Fang Yang, Jianhua Sui

published 18 Sep 2026

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Pre-clinical efficacy of a C4BP hexameric IgG Fc fusion protein against Neisseria gonorrhoeae

Jutamas Shaughnessy, Jintang Du, Mary Wakim Broden, Sunita Gulati, Bo Zheng, Nancy Nowak, Gretchen Telford, Sandy P. Fontes, Y. Tran, Keith L. Wycoff, Kevin J. Whaley, Alison K. Criss, Sanjay Ram

published 25 Aug 2026

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Generation of dual mouse models of retinal degeneration with slow and rapid progression driven by ectopic RIP3 expression

Young Do Song, Jiyeong Kim, Jun-Ho Jang, Youngjin Kim, Hye-Kyoung Oh, Min Jeong Ji, Minji Choi, Minsun Park, Dae-Won Kim

published 20 Aug 2026

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A Transgenic mouse tolerant to syngeneic cancer cells expressing truncated human epidermal growth factor receptor

Theresa Barberi, Rahila Khuroo, Alan D. Friedman

published 07 Aug 2026

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Overexpression of CD97 in intestinal epithelial cells attenuates LPS-induced pro-inflammatory cytokine induction via stabilization of β-catenin early in life

Niklas Dressler, Steffi Mayer, Thomas Wiemers, Florentine Weise, Xiaoyan Feng, Gabriela Aust, Nicole Peukert, Martin Lacher, Jan Riedel

published 30 Jul 2026

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Neuromuscular ultrasound as a biomarker in the SOD1 mouse model of amyotrophic lateral sclerosis

Camilla Wohnrade, Nadine Thau-Habermann, Thomas Gschwendtberger, Julia Rückoldt, Zhong Huang, Stefanie Schreiber, Kirsten Haastert-Talini, Susanne Petri

published 14 Jul 2026

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Germline-mediated ubiquitous recombination in ScxCre male mice: Implications for tendon research

Haiyin Li, Christopher L. Mendias, Chike Cao

published 13 Jul 2026

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Role and mechanism of nitric oxide-regulated cGAS/STING pathway-mediated inflammatory response in hypoglycemia-induced coronary artery endothelial cell injury

Wenping Luo, Xiao Wei, Qian Xiao

published 26 Jun 2026

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