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Genetically modified animals

Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome

Allison R. Hanaford, Asheema Khanna, [ ... ], Simon C. Johnson

Generation and characterization of BAC transgenic mouse lines expressing a fluorescent protein in trigeminal and dorsal root ganglion neurons

Piu Banerjee, Takuya Sato, Takuji Iwasato

Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice

Michaela O. Lunn, Christopher Rousso, [ ... ], Michael G. Schlossmacher

Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPARγ-mediated adipocyte differentiation

Tomokazu Yamaguchi, Midori Hoshizaki, [ ... ], Keiji Kuba

Inhibition of VE-PTP rejuvenates Schlemm’s canal in aged mice and acts via Tie2

Sarthak Mishra, Ute Ipe, [ ... ], Dietmar Vestweber

Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury

Hayato Sasaki, Kazuki Otake, [ ... ], Nobuya Sasaki

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, [ ... ], Gabriele Proetzel

Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse

Xianjuan Zhang, Qing Wang, [ ... ], Yunyang Wang

Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

Leonardo Santos, Rafael Sebastián Fort, [ ... ], Carlos Escande

Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms

Bin Li, Xiao Meng Yang, Xiong Ming Zhou, Yuan Qing Huang

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Hiroshi Tsuneki, Takahiro Maeda, [ ... ], Toshiyasu Sasaoka

Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4⁺ T cells during blood-stage Plasmodium infection

Takahiro Asatsuma, Marcela L. Moreira, [ ... ], Ashraful Haque

Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons

Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

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