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Genetically modified animals

A novel recombinant human plasminogen activator: Efficient expression and hereditary stability in transgenic goats and in vitro thrombolytic bioactivity in the milk of transgenic goats

Zhengyi He, Rui Lu, Ting Zhang, Lei Jiang, Minya Zhou, Daijin Wu, Yong Cheng

published 17 Aug 2018

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TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

Tomoya Hara, Satoshi Nishimura, Toshihiro Yamamoto, Yumiko Kajimoto, Keiji Kusumoto, Ray Kanagawa, Shota Ikeda, Tomoyuki Nishimoto

published 09 Aug 2018

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Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity

Andhira Vieira, Bastien Vergoni, Monica Courtney, Noémie Druelle, Elisabet Gjernes, Biljana Hadzic, Fabio Avolio, Tiziana Napolitano, Sergi Navarro Sanz, Ahmed Mansouri, Patrick Collombat

published 09 Aug 2018

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Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis

Matthew Cummings, Anitha Christy Sigamani Arumanayagam, Picheng Zhao, Sunil Kannanganat, Olaf Stuve, Nitin J. Karandikar, Todd N. Eagar

published 08 Aug 2018

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Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

Bernd O. Evert, Rohit Nalavade, Johannes Jungverdorben, Frank Matthes, Stephanie Weber, Ashish Rajput, Stefan Bonn, Oliver Brüstle, Michael Peitz, Sybille Krauß

published 07 Aug 2018

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Mouse models of sporadic thyroid cancer derived from BRAF^V600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Zhanna Mussazhanova, Hiroki Matsuzaki, Masahiro Nakashima, Masanobu Yamada, Yuji Nagayama

published 07 Aug 2018

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GDF15 deficiency promotes high fat diet-induced obesity in mice

Thanhvien Tran, Jingping Yang, Jonitha Gardner, Yumei Xiong

published 02 Aug 2018

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Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice

Reidun Aesoy, Haruna Muwonge, Kathrine S. Asrud, Misbah Sabir, Solveig L. Witsoe, Ronja Bjornstad, Reidun K. Kopperud, Erling A. Hoivik, Stein Ove Doskeland, Marit Bakke

published 26 Jul 2018

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p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet

Marcus Hollenbach, Nora Klöting, Ines Sommerer, Jana Lorenz, Mario Heindl, Matthias Kern, Joachim Mössner, Matthias Blüher, Albrecht Hoffmeister

published 24 Jul 2018

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nNOS splice variants differentially regulate myofilament function but are dispensable for intracellular calcium and force transients in cardiac papillary muscles

W. Glenn L. Kerrick, Yuanyuan Xu, Justin M. Percival

published 20 Jul 2018

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PNPase knockout results in mtDNA loss and an altered metabolic gene expression program

Eriko Shimada, Fasih M. Ahsan, Mahta Nili, Dian Huang, Sean Atamdede, Tara TeSlaa, Dana Case, Xiang Yu, Brian D. Gregory, Benjamin J. Perrin, Carla M. Koehler, Michael A. Teitell

published 19 Jul 2018

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FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis

Joel B. Heim, Cera A. McDonald, Saranya P. Wyles, Sindhuja Sominidi-Damodaran, Edwin J. Squirewell, Ming Li, Catherine Motsonelidze, Ralph T. Böttcher, Jan van Deursen, Alexander Meves

published 12 Jul 2018

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SAP97 regulates behavior and expression of schizophrenia risk enriched gene sets in mouse hippocampus

Preetika Gupta, Ogul E. Uner, Soumyashant Nayak, Gregory R. Grant, Robert G. Kalb

published 11 Jul 2018

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