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Genetic engineering

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, [ ... ], Gabriele Proetzel

Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse

Xianjuan Zhang, Qing Wang, [ ... ], Yunyang Wang

Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

Leonardo Santos, Rafael Sebastián Fort, [ ... ], Carlos Escande

Polyhydroxyalkanoate production in Priestia megaterium strains from glycerol feedstock

Andrew J. Cal, Victor J. Chan, Winston K. Luo, Charles C. Lee

A mix-and-match reverse genetics system for evaluating genetic determinants of orthobunyavirus neurological disease

Heini M. Miettinen, Matthew J. Abbott, Alyssa B. Evans

Molecular cloning and functional verification of chalcone synthase genes from cassava (Manihot esculenta Crantz) in defense against Tetranychus cinnabarinus infestation

Yanni Yang, Kaiwen Zheng, [ ... ], Ming Liu

Assessing construct reliability through open-ended survey response analysis

Katherine E. Koralesky, Marina A.G. von Keyserlingk, Daniel M. Weary

Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms

Bin Li, Xiao Meng Yang, Xiong Ming Zhou, Yuan Qing Huang

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Hiroshi Tsuneki, Takahiro Maeda, [ ... ], Toshiyasu Sasaoka

Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4⁺ T cells during blood-stage Plasmodium infection

Takahiro Asatsuma, Marcela L. Moreira, [ ... ], Ashraful Haque

Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons

Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis

Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney

Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells

Alyssa Kearly, Prontip Saelee, [ ... ], Lee Ann Garrett-Sinha

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