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Genetic engineering

Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPARγ-mediated adipocyte differentiation

Tomokazu Yamaguchi, Midori Hoshizaki, [ ... ], Keiji Kuba

Inhibition of VE-PTP rejuvenates Schlemm’s canal in aged mice and acts via Tie2

Sarthak Mishra, Ute Ipe, [ ... ], Dietmar Vestweber

Success and limitations in adaptation of Fast-TrACC tissue culture-independent transformation in coffee, cotton, and tree tobacco

Boaz Negin, Laura Daniela Martin-Lesmes, Georg Jander

Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury

Hayato Sasaki, Kazuki Otake, [ ... ], Nobuya Sasaki

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, [ ... ], Gabriele Proetzel

Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse

Xianjuan Zhang, Qing Wang, [ ... ], Yunyang Wang

Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

Leonardo Santos, Rafael Sebastián Fort, [ ... ], Carlos Escande

Polyhydroxyalkanoate production in Priestia megaterium strains from glycerol feedstock

Andrew J. Cal, Victor J. Chan, Winston K. Luo, Charles C. Lee

A mix-and-match reverse genetics system for evaluating genetic determinants of orthobunyavirus neurological disease

Heini M. Miettinen, Matthew J. Abbott, Alyssa B. Evans

Molecular cloning and functional verification of chalcone synthase genes from cassava (Manihot esculenta Crantz) in defense against Tetranychus cinnabarinus infestation

Yanni Yang, Kaiwen Zheng, [ ... ], Ming Liu

Assessing construct reliability through open-ended survey response analysis

Katherine E. Koralesky, Marina A.G. von Keyserlingk, Daniel M. Weary

Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms

Bin Li, Xiao Meng Yang, Xiong Ming Zhou, Yuan Qing Huang

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Hiroshi Tsuneki, Takahiro Maeda, [ ... ], Toshiyasu Sasaoka

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