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Genetic engineering

TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

Tomoya Hara, Satoshi Nishimura, [ ... ], Tomoyuki Nishimoto

Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing

Qiu-Yuan Zhao, Xin-Jian He

Overexpression of the rice gene OsSIZ1 in Arabidopsis improves drought-, heat-, and salt-tolerance simultaneously

Neelam Mishra, Anurag P. Srivastava, [ ... ], Guoxin Shen

Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity

Andhira Vieira, Bastien Vergoni, [ ... ], Patrick Collombat

Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis

Matthew Cummings, Anitha Christy Sigamani Arumanayagam, [ ... ], Todd N. Eagar

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

Bernd O. Evert, Rohit Nalavade, [ ... ], Sybille Krauß

Mouse models of sporadic thyroid cancer derived from BRAF^V600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

Mika Shimamura, Nobuyuki Shibusawa, [ ... ], Yuji Nagayama

GDF15 deficiency promotes high fat diet-induced obesity in mice

Thanhvien Tran, Jingping Yang, Jonitha Gardner, Yumei Xiong

Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice

Reidun Aesoy, Haruna Muwonge, [ ... ], Marit Bakke

p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet

Marcus Hollenbach, Nora Klöting, [ ... ], Albrecht Hoffmeister

nNOS splice variants differentially regulate myofilament function but are dispensable for intracellular calcium and force transients in cardiac papillary muscles

W. Glenn L. Kerrick, Yuanyuan Xu, Justin M. Percival

Evaluation of pathogenicity of Salmonella Gallinarum strains harbouring deletions in genes whose orthologues are conserved pseudogenes in S. Pullorum

Diego Felipe Alves Batista, Oliveiro Caetano de Freitas Neto, [ ... ], Angelo Berchieri Junior

Functional analysis of the HD-Zip transcription factor genes Oshox12 and Oshox14 in rice

Jingxia Shao, Imran Haider, [ ... ], Pieter B. F. Ouwerkerk

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