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Gene expression

Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity

Okkeun Jung, Angelene Soto, Andrew L. Wolfe, Shahana S. Mahajan

published 08 Aug 2025

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Presymptomatic microRNA-based biomarker signatures for the prognosis of localized radiation injury in mice

Lucie Ancel, Jules Gueguen, Guillaume Thoër, Jules Marçais, Aïda Chemloul, Bernard Le Guen, Marc Benderitter, Radia Tamarat, Maâmar Souidi, Mohamed Amine Benadjaoud, Stéphane Flamant

published 08 Aug 2025

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Association of germline variants in the ZFX gene with primary hyperparathyroidism

Ainhoa Camille Aranaga-Decori, Pedro González, Sara Gómez-Conde, Leire Madariaga, Nuria Valdes, Luis Castaño, Alejandro García-Castaño, for the Calcium and Phosphorus Metabolism Molecular Biology Group

published 08 Aug 2025

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Bioinformatics analysis to explore biomarkers and mechanisms of action associated with endoplasmic reticulum stress and ferroptosis in Parkinson’s disease

Hao Wang, Lijuan Feng, Limeng He, Nan Liu, Yan Wan, Wei Zhang

published 08 Aug 2025

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Quantification of H3.1-nucleosomes using a chemiluminescent immunoassay: A reliable method for neutrophil extracellular trap detection

Marion Wargnies, Guillaume Rommelaere, Julie Candiracci, Dorian Pamart, Robin Varsebroucq, Florian Jibassia, Finley Serneo, Virginie Laloux, Olivia Thiry, Fanny Lambert, Alison Lobbens, Priscilla Van den Ackerveken, Marielle Herzog

published 06 Aug 2025

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DNA methylation differences stratified by normalized fetal/placental weight ratios suggest neurodevelopmental deficits in neonates with congenital heart disease

Marin Jacobwitz, Michael Xie, Jamie Catalano, Ingo Helbig, J. William Gaynor, Nancy Burnham, Rebecca L. Linn, Juliana Gebb, Mark W. Russell, Hakon Hakonarson, Barbara H. Chaiyachati, Ana G. Cristancho

published 06 Aug 2025

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A comparison of DNA methylation detection between HiFi sequencing and whole genome bisulfite sequencing in monozygotic twins with Down syndrome

Kanyanee Promsawan, Chalurmpon Srichomthong, Monnat Pongpanich, Vorasuk Shotelersuk

published 05 Aug 2025

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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension

Lin Chen, Jiayao Chen, Jindong Wan, Muqing Shao, Caiyu Chen, Shuo Zheng, Fuwei Zhang, Jian Yang

published 05 Aug 2025

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Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network

Ji Wang, Xinyue Qi, Wangqian Zhao, Ziyan Hao, Kehan Wang, Yuting Li, Yue Wang, Yunshan Zhang

published 04 Aug 2025

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Increased expression of chaperone proteins in response to DENV 2 infection of Huh-7 liver cells

Chanida Chumchanchira, Wannapa Sornjai, Sittiruk Roytrakul, Pathrapol Lithanatudom, Duncan R. Smith

published 01 Aug 2025

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Mechanism of Astragaloside-Brucea javanica oil nanoemulsion against oral squamous cell carcinoma through CDK1/MTFR2: Network pharmacology, bioinformatics, and experimental studies

Yihan Lai, Runqiang Liu, Huajie Shao, Juan Zhan, Yujie Ma, Lanfei Zhou, Zhichao Wan, Sicheng Li, Wei Wang, Lin Jiang, Yisen Shao

published 01 Aug 2025

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Antimicrobial activity of Origanum vulgare L. essential oil and its effects on fungal gene expression

Yan Li, Lu He, Zhiwei Xue, Yu Liang, Jiaying Jiang, Yiyan Wei, Huisi Li, Huimin He, Rongjun Li

published 01 Aug 2025

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OpDetect: A convolutional and recurrent neural network classifier for precise and sensitive operon detection from RNA-seq data

Rezvan Karaji, Lourdes Peña-Castillo

published 01 Aug 2025

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