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Gene expression

Integration of single-cell and bulk RNA sequencing reveals programmed cell death-associated transcriptional programs in sepsis-induced acute lung injury

Xin Li, Weihong Liu, Yucui Zhang, Guohan Xiang, Qianyu Bi, Xin Lin, Yang Liu, Tejin Ba, Li Kong, Yang Liu, Hao Hao

published 03 Jun 2026

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Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer

Xinyao Zhu, Qilong Wu, Yuqi Li, Zhiyu Liu, Yang Zeng, Zhiqiang Zeng, Yubo Zhou, Lunhong Zou, Xiaochun Wu, Dan Zhao, Qingfu Deng, Tao Zhou

published 02 Jun 2026

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Transcriptome sequencing combined with experimental verification to explore potential key genes related to uric acid in diabetic retinopathy

Haiming Liang, Tianqi Yang, Feina Lu, Lixia Lin, Hao Liang

published 02 Jun 2026

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Multi-omics and pan-cancer analysis revealed common molecular signatures to disclose multitargeted anticancer agents through network pharmacology approach

Hriddhi Sarker, Farhad Bin Farid, Marguba Kamrun, Esha Masud, Asif Ahmed, Mamun Miah, Neladre Shaker Roy, Neeraj Kumar, Md Ahad Ali

published 01 Jun 2026

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Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα

Xiaohui Liu, Miki Shimohigashi, Yasuyuki Shimohigashi

published 01 Jun 2026

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Study on the pathogenesis of PLXNB1 gene in olfactory dysfunction of allergic rhinitis

Xinglong Chen, Lingqiong Zhao, Wenlong Luo

published 01 Jun 2026

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Screening and comprehensive analysis of endoplasmic reticulum stress-related biomarkers in atherosclerosis

Xiaomeng Qu, Yiming Shao, Han Li, Yuhan Bao, Zhen Sun, Shuhua Yu

published 01 Jun 2026

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Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells

Jeyalakshmi Kandhavelu, Kumar Subramanian, Natanya Moodley, Kasim S. Abass, Chandrabose Sureka, Meenakshisundaram Kandhavelu, Paul Ruff, Clement Penny

published 01 Jun 2026

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Protocatechuic acid prevents obesity caused by long-chain saturated fatty acid-induced inflammation in mouse microglia via inhibition of the NF-κB pathway

Ken-yu Hironao, Shoma Fujino, Yusei Johta, Kevin Odongo, Hitoshi Ashida, Yoko Yamashita

published 01 Jun 2026

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Multi-omics profiling reveals epidermal growth factor as a potential biomarker and therapeutic target in lupus nephritis and ANCA-associated vasculitis with rapidly progressive glomerulonephritis

Mengli Xu, Qi Cheng, Yifan Xie, Xin Chen, Lingjiang Zhu, Wenjing Su, Yan Du, Huaxiang Wu, Keda Lu

published 29 May 2026

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Comprehensive multi-omics analysis reveals prognostic, immune, and therapeutic signatures of TNFAIP family genes in breast cancer

Tahereh Barati, Madiheh Mazaheri Moghaddam, Fatemeh Mokhles, Zohreh Mirzaei, Amir Ebrahimi, Golsa Nayeb Ghanbar Hosseini, Najaf Allahyari Fard

published 29 May 2026

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GSEA and the coexpression network approach identify novel pathway connections of molecular processes affected in Porto-sinusoidal vascular disease

Aishwarya Iyer, Cenna Doornbos, Chris Evelo, Martina Kutmon, Friederike Ehrhart

published 29 May 2026

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Decreased expression of Ly-1 antibody reactive clone (Lyar) triggers enhanced adipogenesis of bone marrow mesenchymal stromal cells in aged bone marrow

Yu Shinyashiki, Yuta Onodera, Yusuke Kawashima, Natsumi Iwawaki, Toshiyuki Takehara, Koji Goto, Takeshi Teramura

published 27 May 2026

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