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Gene expression

Bidirectional phenotypic transition in macrophages influences triple-negative breast cancer cell immune evasive patterns and response to chemotherapies in a co-culture spheroid model

Chen Cheng, Brett A. McGregor, Junguk Hur, Colin K. Combs

Environmental enrichment attenuates chronic stress–induced disruptions in the gut microbiota, intestinal barrier, and brain

Seung Ju Kang, Hyeong Ju Nam, Min Kyung Song

Prediction of potential biomarkers and therapeutic targets in HIV viremic patients using immune-related circRNA-miRNA-mRNA regulatory networks

Negin Faraji, Leila Rouhi, [ ... ], Ladan Abbasian

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

Qin Meng, Xujia Wang, [ ... ], Mu Wang

Regulatory effects of smoking cessation on the cellular microenvironment and differentially expressed genes in precancerous lesions of pulmonary nodules in mice based on single-cell RNA sequencing and immune repertoire-sequencing

Xintong Wang, Fang Tang, [ ... ], Chunli Che

Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses

Yonghong Li, Jianan He, [ ... ], Mengsha Qi

Integrative bioinformatics analysis identifies gut microbiota-derived metabolite-associated immune candidate targets in high-risk primary biliary cholangitis

Jing Feng, Zhiyun Liu, Huanna Sun

L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Yuki Tamari, Rie Saba, [ ... ], Kei Yamada

Network pharmacology and molecular simulation study on the multi-target gene regulatory mechanism of Isatis indigotica against hepatic inflammation

XueRu Li, Yang Wang, [ ... ], XiaoLu Chen

Integrating dynamic modeling of signaling pathways with subject-specific transcriptomic data to assess breast cancer risk

Piyanut Ratphibun Yamashita, Anuwat Tangthanawatsakul, [ ... ], Teeraphan Laomettachit

Unraveling the molecular Nexus of Alzheimer’s Disease and HIV encephalitis: The role of cellular senescence and transcriptional regulation

Hao Zhang, WenJun Chen, [ ... ], GuoXun Shi

Shedding light on neural learning to rank models for anticancer drug prioritization

Faraz Sarmeili, Benyamin Ghahremani-Nezhad, [ ... ], Hamid R. Rabiee

Apoptosis-related genes bridge inflammatory bowel disease and osteoporosis: A bioinformatic analysis

Yue Su, Xiaohui Luo, Haitao Xu

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