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ERK signaling cascade

Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor

Yoshimasa Suzuki, Makoto Sugimori, Yushi Kanemaru, Sho Onodera, Hiromi Tsuchiya, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Hiroaki Kaneko, Kuniyasu Irie, Soichiro Sue, Hideaki Ijichi, Shin Maeda

published 10 Jul 2025

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5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway

Wenyue Hou, Ting Zou, Yichao Yan, Yaolong Zhuang, Shaomei Gao, Huijun Ju, Fei Yao, Qin Yuan, Liang Zhou, Guoqiang Liang, Xiudao Song, Lurong Zhang

published 05 May 2025

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Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associated ophthalmopathy

Ji-Young Lee, Seong-Beom Lee, Suk-Woo Yang, Ji-Sun Paik

published 18 Dec 2024

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An in silico molecular docking and simulation study to identify potential anticancer phytochemicals targeting the RAS signaling pathway

Mahir Azmal, Jibon Kumar Paul, Fatema Sultana Prima, Omar Faruk Talukder, Ajit Ghosh

published 19 Sep 2024

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Exploiting mechanisms for hierarchical branching structure of lung airway

Hisako Takigawa-Imamura, Katsumi Fumoto, Hiroaki Takesue, Takashi Miura

published 30 Aug 2024

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Sustained intestinal epithelial monolayer wound closure after transient application of a FAK-activating small molecule

Sema Oncel, Qinggang Wang, Ahmed Adham R. Elsayed, Emilie E. Vomhof-DeKrey, Nicholas D. Brown, Mikhail Y. Golovko, Svetlana A. Golovko, Ricardo Gallardo-Macias, Vadim J. Gurvich, Marc D. Basson

published 16 Aug 2024

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Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis

Da-eun Nam, Soo-Jeung Park, Samson Omole, Eugene Um, Ramin M. Hakami, Young S. Hahn

published 27 Jun 2024

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Xa inhibitor edoxaban ameliorates hepatic ischemia-reperfusion injury via PAR-2–ERK 1/2 pathway

Koki Maeda, Naohisa Kuriyama, Daisuke Noguchi, Takahiro Ito, Kazuyuki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Shugo Mizuno

published 15 May 2024

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Stellera chamaejasme L. extract inhibits adipocyte differentiation through activation of the extracellular signal-regulated kinase pathway

Jaegoo Yeon, Eunbin Kim, Badamtsetseg Bazarragchaa, Soo-Yong Kim, Jin Young Huh, Hyuntae Park, Sung-Suk Suh, Jong Bae Seo

published 21 Mar 2024

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Regulation of gene expression downstream of a novel Fgf/Erk pathway during Xenopus development

Laura M. Cowell, Michael King, Helena West, Matthew Broadsmith, Paul Genever, Mary Elizabeth Pownall, Harry V. Isaacs

published 19 Oct 2023

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Inhibition of ERK signaling for treatment of ERRα positive TNBC

David Musheyev, Esther Miller, Natania Birnbaum, Elisheva Miller, Shoshana Erblich, Alyssa Schuck, Anya Alayev

published 10 May 2023

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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton’s tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics

Ryohei Kozaki, Tomoko Yasuhiro, Hikaru Kato, Jun Murai, Shingo Hotta, Yuko Ariza, Shunsuke Sakai, Ryu Fujikawa, Takao Yoshida

published 10 Mar 2023

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Hsa-miR-22-3p inhibits liver cancer cell EMT and cell migration/ invasion by indirectly regulating SPRY2

Shuaishuai Cui, Yuanyuan Chen, Yunfei Guo, Xing Wang, Dahu Chen

published 07 Feb 2023

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