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Enzyme chemistry

Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin

Xin Zhou, Yanru Deng, Caihui Guo, Ying Li, Yuhao Fu, Zhi Wang, Zhanjun Dong

published 22 Jun 2026

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Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics

Begoña Tapia-Alzuguren, Covadonga Canga-Espina, Patricio Molero, Azucena Aldaz

published 10 Jun 2026

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Light quality-regulated anthocyanin biosynthesis in Lilium leichtlinii subsp. maximowiczii bulbs: A multi-omics perspective

Jinxing Xu, Shuai Li, Chen Wang, Bingyan Liu, Qi Wu, Yanli Ma, Xinzhu Dai, Yuanhang Zhou, Xinhai Yu, Tianliang Wang

published 13 May 2026

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Unguided web-based brief intervention with genetic risk education to reduce unhealthy alcohol consumption in Japan: Protocol for a randomized controlled trial

Yuki Kono, Mai Tanaka-Sahker, Shino Kikuchi, Yan Luo, Masatsugu Sakata, Ryuhei So, Tamara L. Wall, Toshi A. Furukawa, Ethan Sahker

published 17 Apr 2026

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SHPRH together with the Ube2D family of enzymes directly ubiquitinates PCNA at Lys164 in vitro

Xinyang Wang, Yixiong Hu, Yajiao Wen, Miaomiao Shen, Pu Chen, Song Xiang

published 16 Apr 2026

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Expanding the toolkit of LacI/GalR chimeras

Carter J. Gray, Pierce T. O’Neil, Kristen M. Schwingen, Carrie Hillebrand, Liskin Swint-Kruse

published 07 Apr 2026

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Effects of increasing molybdenum under low nitrogen input on yield, nitrogen-metabolizing enzymes and nitrogen use efficiency of winter wheat cultivars

Di Yang, Qixia Wu, Youning Wang

published 05 Mar 2026

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Regulatory mechanisms of amino acid metabolic pathways in Rhododendron chrysanthum Pall. Under UV-B stress

Jie Lyu, Xiangqun Li, Wang Yu, Xiangru Zhou, Hongwei Xu, Xiaofu Zhou

published 02 Mar 2026

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Prevalence of polypharmacy and drug interactions in geriatric patients: A cross-sectional study from India

Umaima Farheen Khaiser, Rokeya Sultana, Ranajit Das, Saeed G. Alzahrani, Madhumitha Kannan, Mohammed Khairt Newigy, Mohammed Sharique Ahmed Quadri, Mujeeb Ahmed Shaikh, Farha M. Shaikh, Mohammad Fareed

published 11 Feb 2026

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Biodegradation of polyethylene terephthalate microplastics by Paenibacillus naphthalenovorans PETKKU2: Response surface optimization and genomic evidence for an alternative degradation mechanism

Aophat Choonut, Nantharat Wongfaed, Auraiwan Poolpol, Sophon Boonlue, Kitirote Wantala, Onruthai Pinyakong, Pensri Plangklang, Alissara Reungsang

published 04 Feb 2026

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Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway

Jacobo Sevillano-Serrano, Fernando Uriel Rojas-Rojas, Alfonso Méndez-Bravo, Nancy Calderón-Cortés, Harumi Shimada-Beltrán, Julio Vega-Arreguín

published 30 Jan 2026

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity

Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada, Shinpei Yamaguchi

published 29 Dec 2025

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Structural flexibility of the nicotinamide group of NADH in butanol dehydrogenase YqdH from Fusobacterium nucleatum

Xue Bai, Ki Hyun Nam, Yongbin Xu

published 17 Dec 2025

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