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DNA damage

SHPRH together with the Ube2D family of enzymes directly ubiquitinates PCNA at Lys164 in vitro

Xinyang Wang, Yixiong Hu, Yajiao Wen, Miaomiao Shen, Pu Chen, Song Xiang

published 16 Apr 2026

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The Physicochemical Synergy Effect of Nanosecond Pulsed Electric Fields (nsPEF) and cisplatin on reversing chemoresistance of bladder cancer

Danjing Guo, Xiao Li, Xiaobo Xu, Xinhua Chen, Hongqiang Cheng, Junhui Jiang

published 16 Apr 2026

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HIF1α mediates resistance to radiation and to KRAS inhibitors in pancreatic adenocarcinoma

Kevin J. Tu, Sanjit K. Roy, Tami J. Kingsbury, Hem D. Shukla

published 26 Mar 2026

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HMGB1 reduce DNA damage by binding KU70 to activate NHEJ pathway in colorectal cancer cells after radiation

Xiuxin Liu, Yuhui Han, Ruixue Kuang, Wenjiong Sheng, Yan Zhang, Xinyu Jia, Xiaoxiao Gao, Yanchao Ma

published 24 Mar 2026

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Differential modulation of haematopoietic and oxidative injury by PARP-1 and ATR kinase inhibition in a murine model of acute irradiation

Baydaa Taher Sih

published 06 Mar 2026

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Therapeutic role of Cousinia thomsonii in ameliorating the oxidative stress and inflammation: A comprehensive in vitro and in vivo investigation

Bilal Ahmad Reshi, Asif Amin, Umer Majeed, Mushtaq Ahmad Mir, Nasreena Bashir, Raies A. Qadri, Showkat Ahmad Ganie

published 06 Mar 2026

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Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype

Xuerao Ning, Thảo Thi Thanh Nguyễn, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi, Masatoshi Tagawa

published 23 Feb 2026

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Omics-aided design genome editing strategy for challenging human immortalized cell models

Patricia Mendoza-Garcia, Benjamin Keith, Markus Nordberg, Ella Quist, Cristina Ferrás, Ghaith M. Hamza, Ramy Elgendy, Stephanie Kay Ashenden, Jordi Chi, Natalie R. van Zuydam, Neil Hattersley, Xiang Zhang

published 12 Feb 2026

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Non-destructive DNA extraction for recovering mitochondrial genomes from museum grasshopper specimens

Hao Tang, Jiayi Zou, Keyao Zhang, Huateng Huang

published 02 Feb 2026

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Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor

Arun R. K. Kumar, Crystal Sara Shaji, Aswathi Rajagopalan, Sombodhi Bhattacharya, Wilner Martínez-López, Radha Saraswathy

published 20 Jan 2026

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Evaluation of the uncertainty in calculating nanodosimetric quantities due to the use of different interaction cross sections in Monte Carlo track structure codes

Carmen Villagrasa, Giorgio Baiocco, Zine-El-Abidine Chaoui, Michael Dingfelder, Sébastien Incerti, Pavel Kundrát, Ioanna Kyriakou, Yusuke Matsuya, Takeshi Kai, Alessio Parisi, Yann Perrot, Marcin Pietrzak, Jan Schuemann, Hans Rabus

published 09 Jan 2026

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Improved birth rates via rehydration of mouse freeze-dried spermatozoa using high-temperature ultrapure water

Kango Yamaji, Sayaka Wakayama, Natsuki Ushigome, Daiyu Ito, Teruhiko Wakayama

published 05 Jan 2026

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Characterization of p53 p.T253I as a pathogenic mutation underlying Li-Fraumeni Syndrome

Nathaniel C. Holcomb, Amanda M. Harrington, Hong Pu, Berina Halilovic, Nathan R. Shelman, Shulin Zhang, Catherine Sears, Terra Armstrong, Brent Shelton, Lauren Corum, John A. D'Orazio

published 05 Dec 2025

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