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Complement inhibitors

Eculizumab and ravulizumab clinical trial and real-world pharmacovigilance of meningococcal infections across indications

Cynthia Carrillo Infante, Arshad Mujeebuddin

published 12 Sep 2025

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Improvements in hematologic markers and decreases in fatigue with pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and mild or moderate anemia (hemoglobin ≥10 g/dL) who had received eculizumab or were naive to complement inhibitors

Jens Panse, Nicolas Daguindau, Sonia Okuyama, Régis Peffault de Latour, Philippe Schafhausen, Nicole Straetmans, Mohammed Al-Adhami, Emmelie Persson, Raymond Siu Ming Wong

published 29 Jul 2024

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Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis

Sara T. Ibrahim, Marwa R. Abdelhamid, Neveen Lewis, Nahed Baddour, Ahmed G. Adam

published 13 Oct 2022

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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates

Kishor Devalaraja-Narashimha, Cong Huang, Marc Cao, Ya Ping Chen, Anna Borodovsky, William C. Olson, Lori G. Morton, Marc W. Retter

published 16 Jun 2022

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Systemic complement activation levels in Stargardt disease

Patty P. A. Dhooge, Esmee H. Runhart, Catherina H. Z. Li, Corrie M. de Kat Angelino, Carel B. Hoyng, Renate G. van der Molen, Anneke I. den Hollander

published 25 Jun 2021

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No evidence for hypogammaglobulinemia in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with ravulizumab

Ferras Alashkar, Scott Rottinghaus, Colin Vance, Dörte Herich-Terhürne, Ulrich Dührsen, Roland Assert, Alexander Röth

published 27 Mar 2020

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Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants

Pamela S. Hair, Adrianne I. Enos, Neel K. Krishna, Kenji M. Cunnion

published 31 Dec 2019

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Identification, cloning and characterization of SpEX exotoxin produced by Staphylococcus pseudintermedius

Mohamed A. Abouelkhair, David A. Bemis, Richard J. Giannone, Linda A. Frank, Stephen A. Kania

published 29 Jul 2019

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Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab

Alaa H. Sewid, M. Nabil Hassan, A. M. Ammar, David A. Bemis, Stephen A. Kania

published 23 Jul 2019

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Genetic strategy to decrease complement activation with adenoviral therapies

Christopher M. Gentile, Anton V. Borovjagin, Jillian R. Richter, Aditi H. Jani, Hongju Wu, Kurt R. Zinn, Jason M. Warram

published 26 Apr 2019

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Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy

Lena Duchateau, Lorena Martín-Aguilar, Cinta Lleixà, Andrea Cortese, Oriol Dols-Icardo, Laura Cervera-Carles, Elba Pascual-Goñi, Jordi Diaz-Manera, Ilaria Calegari, Diego Franciotta, Ricard Rojas-Garcia, Isabel Illa, Jordi Clarimon, Luis Querol

published 22 Feb 2019

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Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation

Yansong Li, Zhangsheng Yang, Mikulas Chavko, Bin Liu, Olawale A. Aderemi, Milomir O. Simovic, Michael A. Dubick, Leopoldo C. Cancio

published 22 Aug 2018

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A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention

Nehemiah Zewde, Dimitrios Morikis

published 06 Jun 2018

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