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Complement inhibitors

Eculizumab and ravulizumab clinical trial and real-world pharmacovigilance of meningococcal infections across indications

Cynthia Carrillo Infante, Arshad Mujeebuddin

Improvements in hematologic markers and decreases in fatigue with pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and mild or moderate anemia (hemoglobin ≥10 g/dL) who had received eculizumab or were naive to complement inhibitors

Jens Panse, Nicolas Daguindau, [ ... ], Raymond Siu Ming Wong

Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis

Sara T. Ibrahim, Marwa R. Abdelhamid, [ ... ], Ahmed G. Adam

Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates

Kishor Devalaraja-Narashimha, Cong Huang, [ ... ], Marc W. Retter

Systemic complement activation levels in Stargardt disease

Patty P. A. Dhooge, Esmee H. Runhart, [ ... ], Anneke I. den Hollander

No evidence for hypogammaglobulinemia in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with ravulizumab

Ferras Alashkar, Scott Rottinghaus, [ ... ], Alexander Röth

Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants

Pamela S. Hair, Adrianne I. Enos, Neel K. Krishna, Kenji M. Cunnion

Identification, cloning and characterization of SpEX exotoxin produced by Staphylococcus pseudintermedius

Mohamed A. Abouelkhair, David A. Bemis, [ ... ], Stephen A. Kania

Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab

Alaa H. Sewid, M. Nabil Hassan, [ ... ], Stephen A. Kania

Genetic strategy to decrease complement activation with adenoviral therapies

Christopher M. Gentile, Anton V. Borovjagin, [ ... ], Jason M. Warram

Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy

Lena Duchateau, Lorena Martín-Aguilar, [ ... ], Luis Querol

Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation

Yansong Li, Zhangsheng Yang, [ ... ], Leopoldo C. Cancio

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention

Nehemiah Zewde, Dimitrios Morikis

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