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Clinical trials

The STRENGTH Study: A cluster randomised controlled trial of the effect of a behaviour change intervention added to cardiac rehabilitation on physical activity adherence

Clare T. M. Doherty, Mark A. Tully, Jason J. Wilson, Leonie Heron, Helen McAneney, Victoria Irving, Lisa Spratt, Rachel O’Reilly, Kim Kensitt, Nicole E. Blackburn

published 24 Mar 2026

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Comparative efficacy and safety of Chinese botanical drug injection in patients with sepsis: A systematic review and Bayesian network meta-analysis of randomized clinical trials

Yue Yuan, Jiajia Wang, Siyuan Lei, Jiansheng Li

published 24 Mar 2026

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Coenrollment of critically ill patients in PROSPECT: A protocol and statistical analysis plan

Alex Thabane, Diane Heels-Ansdell, Nicole Zytaruk, Deborah Cook, for the PROSPECT Investigators and the Canadian Critical Care Trials Group

published 23 Mar 2026

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A randomised controlled feasibility study of the Carers-ID intervention to support the mental health of family carers of people with intellectual disabilities

Rachel A. Leonard, Maria Truesdale, Michael Brown, Lynne Marsh, Stuart Todd, Nathan Hughes, Trisha Forbes, Ashleen Crowe, Mark A. Linden

published 20 Mar 2026

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IMPlementing IMProved Asthma self-management as RouTine (IMP²ART) in UK primary care: An internal pilot for a cluster randomised controlled trial

Kirstie McClatchey, Daisy Bertram, Atena Barat, Brigitte Delaney, Vicky Hammersley, Barbara Korell, Viv Marsh, Megan Preston, Jessica Sheringham, Liz Steed, Steven Julious, David Price, Stephanie J. C. Taylor, Hilary Pinnock

published 20 Mar 2026

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Combined repetitive transcranial magnetic stimulation and functional electrical stimulation cycling to improve lower extremity function following incomplete spinal cord injury: Protocol for a pilot randomized controlled trial

Fereshteh Ghahremani, Siobhan Schabrun, Sue Peters, Laura Brunton, Janelle Unger

published 19 Mar 2026

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Effect of accentuated eccentric loading countermovement jumps and drop jump training with ladder training versus ladder training alone on sprint performance and change of direction ability in futsal players: A randomized controlled trial protocol

Darpan Chaudhari, Swapnil U. Ramteke

published 19 Mar 2026

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Helping primary care providers recognize and respond to medication non-adherence and drug-drug interactions: A randomized-controlled clinical utility trial in a value-based care setting

Trever Burgon, David Paculdo, Joshua Schrecker, Kelsy Gibson Ferrara, Randy E. David, Steven Johnson, Czarlota Valdenor, John W. Peabody

published 16 Mar 2026

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A pilot randomized controlled trial to explore the feasibility of a peer-delivered single-session brief intervention for youth with moderate risk substance use

Florence Jaguga, Matthew Turissini, Edith Kamaru Kwobah, Edith Apondi, Leslie A. Enane, Julius Barasa, Gilliane Kosgei, Yvonne Olando, Mary A. Ott, Allan Kimaina, Matthew C. Aalsma

published 16 Mar 2026

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Study protocol for a feasibility randomised controlled trial of MOVE SMART—An intervention to increase physical activity, reduce sedentary behaviour and improve health outcomes in patients with psoriasis

Gladys Onambele-Pearson, Ben Ives, Ishani Khosla, Rozemarijn Witkam, Matthew Roberts, Lucy Moorhead, Emma Bedson, Russ Cowper, Girvan Burnside, Helen S. Young

published 16 Mar 2026

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The effect of exercise intervention on atherosclerosis prevention in overweight or obese adults: A Bayesian network meta-analysis of randomized controlled trials

ChunBaiXue Yang, Yang Xu, XiuPeng Li, HangLin Yu, MingRui Wang, Bing Yang

published 13 Mar 2026

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The dolutegravir failure cohort: A multi-country longitudinal cohort with a randomised clinical trial of continued dolutegravir versus switch to darunavir in people with viraemia while on dolutegravir in Sub-Saharan Africa (The Ndovu Study) protocol

Loice Achieng Ombajo, Joseph Nkuranga, Jeremy Penner, Emily Wangui Kamau, Nalia Ismael, Patricia Munseri, Irene Ayakaka, Niklaus Labhardt, Dalton Wamalwa, Patricia Ramgi, Raquel Matavele Chissumba, James Wagude, Muhammad Bakari, Victor Omodi, Edwin Otieno, Lisa Abuogi, Rena Patel, Charles Opondo, Daniel Grint, Leonard King’wara, AnneMarie Macharia, Andrew Mulwa, Patrick Amoth, on behalf of the Ndovu study group

published 13 Mar 2026

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Cure rate estimation with insufficient follow-up: A median-based bootstrap correction approach

Yumiko Ibi, Takashi Omori

published 12 Mar 2026

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