Advertisement

Browse Subject Areas

?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

Clinical research design

A multicenter, randomized, parallel-group confirmatory study protocol to evaluate the efficacy of Soft Protector CPC, a novel oral mucosal protectant, in preventing oral mucositis and alleviating pain in patients with breast cancer

Kazuhiro Omori, Kohei Furukawa, Masatoshi Usubuchi, Tomofumi Hamada, Tadahiko Shien, Michihiro Yoshida, Yuki Nakatsuka, Katsuyuki Hotta, Soichiro Ibaragi, Shogo Takashiba

published 04 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Comparing the safety and efficacy of sodium valproate, levetiracetam, and phenytoin in attenuating the severity of agitation in patients with post-traumatic brain injury: An observational study

Shivani Singh, Raghavendra Nayak, Shivaprakash Gangachannaiah, Ashutosh Bhosale, Reena Sherin Parveen, Varun Kumar S G, Geeta Sundar

published 03 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

The routine use of nasopharyngeal airway in the setting of monitored anesthesia care during gastrointestinal endoscopy: A multi-center single blinded randomized controlled trial

Christian Raphael, Nancy Abou Nafeh, Marc Moukarzel, Thuraya HajAli, Eliane Alhalabi, Aliyya Dabbous, Raji Naamani, Patrick Maroun, Yasser Sheib, Marie T. Aouad, Rony Al Nawwar

published 03 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Aldosterone synthase inhibitors in uncontrolled and resistant hypertension: A phenotype-stratified systematic review and network meta-analysis of randomized trials

Ismaila Ajayi Yusuf, Olurotimi J. Badero, Alozie Ihesiulo, Micah Nnabuko Okwah, Abieyuwa Oshodin, Emmanuella Asikong

published 03 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Magnesium in acute pediatric asthma in the emergency department (MAGICIAN)—A multicentre randomized controlled clinical trial protocol

Suzanne Schuh, Sunita O’Shea, Stephen B. Freedman, Mohamed Eltorki, Jocelyn Gravel, Francine M. Ducharme, Waleed Alqurashi, Roger Zemek, George Wells, Jesse Elliott, April Kam, Sarah Curtis, Allan L. Coates, Terry Klassen, Mark Bedford, Yaron Finkelstein, for the Pediatric Emergency Research Canada (PERC) network

published 03 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Tumor hypoxia is associated with global copy-number alteration burden and subtype-dependent overall survival in breast cancer: Evidence from TCGA and METABRIC

Wenhan Yang

published 02 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Can immersive virtual reality magnify treatment outcomes of computerized script training on Cantonese speakers with chronic aphasia? Protocol of a randomized controlled trial

Winsy Wing Sze Wong, Donald Shi Pui Li, Kenneth Ngai Kuen Fong, Peter Hiu Fung Ng, Hoi Tsz Karen Kwok

published 02 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Ring-augmented versus conventional one-anastomosis gastric bypass: Perioperative and short-term results in the randomized controlled RiMini trial

Maureen Tissink, Josien Timmerman, Marloes Vermeer, Tim Verhagen, Ian Faneyte, Eric Hazebroek, Marc van Det

published 01 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Identification of drug-related cardiovascular risks: A comprehensive analysis using the FAERS database (2004–2024)

Naishen Qin, Yumei Gan, Jun Ouyang, Jiahui Qin, Yuming Tang, Haili Wu, Shumin Wei, Hui Wang, Jiangnan Huang

published 01 Jun 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Photobiomodulation for pain management during placement of the copper T 380 intrauterine device: Protocol for a randomized, double-blind controlled trial

Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

published 28 May 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Comparison of dose-adjusted EPOCH-R and R-CHOP in diffuse large B-cell lymphoma with high Ki67 expression: Results from a prospective observational study

Wenxin Jiang, Peng Liu

published 22 May 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database

Qiaoling Pan, Hang Chen, Hanbo Pan, Zeyang Hu, Keyue Qiu, Jiaheng Zhang, Ni Li, Yinyu Mu, Keyun Zhu, Guodong Xu, Yiming Shen

published 22 May 2026

Loading metrics information...

Metrics unavailable. Please check back later.

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial

Eleanor Jackson, Timothy Riley, Paul G. Overton

published 20 May 2026

Loading metrics information...

Metrics unavailable. Please check back later.

Advertisement

Create a weekly email alert for: Clinical research design

You can change these options by clicking profile then "Alerts and Notifications"