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Clinical research design

Assessing the real-world safety of vutrisiran for transthyretin-mediated amyloidosis with polyneuropathy: Based on WHO-VigiAccess and FAERS databases

Weiwei Tong, Yaxing Li, Xingli Xu, Yang Mao, Ruonan Zhang, Chuanliang Zhao, Jidang Zhang, Chigang Du, Jiayue Feng

published 15 Apr 2026

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Exploring scalable assessment methods for terminated trials in ClinicalTrials.gov: A cohort analysis of German and Californian trials

Samruddhi Suresh Yerunkar, Benjamin Gregory Carlisle, Delwen L. Franzen, Maia Salholz-Hillel, Daniel Strech, Susanne Gabriele Schorr

published 15 Apr 2026

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Nutritional prehabilitation in head and neck cancer patients (PreHead) – A randomized controlled trial study protocol

D. Sijbrands, D. Gort-van Dijk, S.A.H.J. de Visscher, A. van der Hoorn, R.J.H.M. Steenbakkers, H. Jager-Wittenaar, G.H. de Bock, A.T. Zwart, G.B. Halmos, I. Wegner

published 15 Apr 2026

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Effect of intravenous vitamin C administration on chemotherapy-induced adverse events in patients with nasopharyngeal cancer

Peesit Leelasawatsuk, Pasawat Supanimitjaroenporn, Nattida Rodsom, Theepat Wongkittithaworn, Manupol Tangthongkum

published 13 Apr 2026

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Adverse events in different administration routes of Edaravone: A pharmacovigilance study based on the FDA adverse event reporting system

Deye Ge, Liyan Wu, Jingrong Yang, Jingxian Sun, Jinying Wang, Jingxin Wang, Huihui Song, Ran Wei, Zecheng Xu, Binbin Zhao, Rongfei Sun, Yifei Wang

published 13 Apr 2026

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Full-day sleep pattern analysis in common mental disorders: Leveraging highly discrepant recordings from two consumer tracking devices

Óscar Jiménez Rama, Antonio Artés, Enrique Baca-García, Jorge López-Castromán

published 09 Apr 2026

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Prevention of oral mucositis in patients undergoing cancer chemotherapy using betamethasone mouthwash: A multicenter randomized controlled trial protocol

Sakiko Soutome, Tomofumi Hamada, Hiromi Nishi, Eiji Iwata, Hirokazu Nakahara, Toshiro Yamamoto, Tatsushi Matsumura, Masaya Nishikawa, Kei Tomihara, Koichiro Ueki, Mamoru Noda, Makoto Shimanishi, Madoka Funahara, Masami Kawahara, Yoshiko Yamamura, Shinpei Matsuda, Kensuke Yoshida, Sanshiro Kanazawa, Minako Otsuji, Nagato Natsume, Masahiro Umeda, Research Committee of the Japanese Society of Oral Care

published 08 Apr 2026

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The sleep-first effect of perampanel in children with self-limited epilepsy with centrotemporal spikes: A temporal efficacy analysis in the context of complex polytherapy

Biao Jiang, Ninger Zhang, Xiaoli Shao

published 07 Apr 2026

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Real-world safety of aliskiren in primary hypertension: A cross-database study

Meirong Shan, Qian Guo, Ruofei Li, Ni Li, Yanhua Fu, Huanyu Qi, Ge Zhang, Qian Wang, Xingli Xu, Jinchuan Lai

published 03 Apr 2026

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Safety and efficacy of Vectored thermal pulsation, Intense pulsed light, and Eyelid Warm compress therapies (VIEW) for meibomian gland dysfunction: Study design and baseline characteristics of a randomized controlled trial

Zhichao Hu, Hanson Yiu Man Wong, Emily Hoi Ying Chan, Eric Ka Ho Choy, Andy Chak Fung Ng, Xulin Liao, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Kenneth Ka Hei Lai, Charlotte Yi Sum Poon, Wanxue Chen, Vanissa Wing See Chow, Clement Chee Yung Tham, Chi Pui Pang, Kelvin Kam Lung Chong

published 02 Apr 2026

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Factors Predicting successful treatment outcome with novel BPaLM/BPaL regimen in individuals with drug-resistant tuberculosis: Experience From Indonesia

Arto Yuwono Soeroto, Aga Purwiga, Hendarsyah Suryadinata, Bachti Alisjahbana, Afiatin Makmun, Yana Akhmad Supriatna, Emmy Hermiyanti Pranggono, Bony Wiem Lestari

published 01 Apr 2026

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Effects of two side-by-side camera trap deployments on estimations of richness, abundance, and the detection of medium- and large-sized mammals

Sergio Guerrero-Vázquez, Silvia S. Zalapa, Salvador Mandujano, Ahtziri S. Basilio-Barrera, Marisela Pérez-Moreno

published 27 Mar 2026

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Effect of dexmedetomidine combined with the modified Trendelenburg position on intraocular pressure in patients undergoing robot-assisted laparoscopic surgery: A randomized controlled trial

Shuyang Yan, Jindong Liu, Beibei Xiao, Chunyan Guo, Binghan Wang, Runhan Shi, Qian Deng

published 27 Mar 2026

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