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Carcinogenesis

A biologically constrained agent-based model of cancer stem cell dynamics with reinforcement learning-guided adaptive radiotherapy

Mina Lagzian, S. Ehsan Razavi, Reyhane Kardehi Moghaddam

published 05 Feb 2026

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WNK2 may promote ovarian cancer progression by upregulating POU5F1B

Fengjie Li, Yongqin Jia, Xiaoli Min, Pangyang Zhang, Yudi Li, Deng Li, Lanqin Cao, Yanzhou Wang, Zhiqing Liang

published 02 Feb 2026

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Prediction of myeloid malignant cells in Fanconi anemia using machine learning

Luis A. Flores-Mejía, Pablo Siliceo, Ulises Juárez Figueroa, Angel A. De la Cruz, Cecilia Ayala-Zambrano, Hugo Tovar, Sara Frías, Alfredo Rodríguez

published 20 Jan 2026

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Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies

Burhan Ul Haq, Shazia Sofi, Hina Qayoom, Nusrat Jan, Asma Jan, Mohammad Aljasir, Irshad Ahmad, Abdullah Almilabairy, Fuzail Ahmad, Bader Alshehri, Manzoor Ahmad Mir

published 05 Dec 2025

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A protocol for using human genetic data to identify circulating protein level changes that are the causal consequence of cancer processes

Lisa M. Hobson, Richard M. Martin, Karl Smith-Byrne, George Davey Smith, Gibran Hemani, Joseph H. Gilbody, James Yarmolinsky, Sarah E.R. Bailey, Lucy J. Goudswaard, Philip C. Haycock

published 05 Dec 2025

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N-glycosylation of NANOG regulates stemness and apoptosis in colon cancer cells

Yin Tian, Yu Zeng, Yun Liu, Jun Ye, Xin Zhang

published 20 Nov 2025

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In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen – 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima

Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage, Prabudhi S. Garusinghe, Damith Chathuranga, Vinoda D. Athukorala, Ashein Kothalawala, Asirini H. Jayasekara, Rajitha K. Rathnayaka, Umanda Anjalee De Silva, Mohamed Faries, Thimali H. Weragoda, Shalini K. Wijerathne, Umapriyatharshini Rajagopalan, Kanishka S. Senathilake, Kamani H. Tennekoon, Achyut Adhikari, Sameera R. Samarakoon

published 03 Nov 2025

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STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells

Wei Ni Yew, Christopher James Dean, Dedrick Kok Hong Chan

published 15 Oct 2025

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The role of lncRNA SNHG15 in UV-induced DNA damage repair

Xin Zhang, Jiahui Lin, Zixuan Fan, Sai Zhang, Meiqi Yang, Tingting Zhu, Qing Lu, Yuming Wang

published 09 Oct 2025

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Frizzled 7 drives amplification of cancer stem-cell subpopulations and the aggressiveness and poor differentiation of human hepatocellular carcinoma

Anaïs Lopez, Alexia Paturel, Nadim Fares, Floriane Pez, Guanxiong Wang, Patricia Gifu, Lydie Lefrançois, Jihed Chouaref, Pierre Saintigny, Janick Selves, Jean-Marie Peron, Michel Rivoire, Philippe Merle, Claude Caron de Fromentel

published 07 Oct 2025

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Role of c-Myc activating the transcription of PD-L1 in immune escape during benzene-induced malignant transformation of human lymphoblasts

Qihao Huang, Biyan Ye, Zhongming Ye, Shuyun Huang, Jiancheng Xue, Fengzhen Cui, Tikeng Jiang, Lei Sun, Yutao Zeng, Shaoying Wang, Yuting Chen, Huanwen Tang

published 12 Sep 2025

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Integrative network toxicology and molecular docking reveal 4-Nonylphenol’s multifaceted mechanisms in breast cancer pathogenesis

Congli Jia, Fu Yang

published 09 Sep 2025

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Sex-dependent effects of a gestational ketogenic diet on offspring birth and lifespan

Sarah M. Zala, Renata Santos, Eva Strasser, Alice Schadde, Sarah Kugler, Verena Strauss, Anna Kübber-Heiss, Diana Zala

published 17 Jul 2025

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