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Carcinogenesis

Trp53 loss drives the neoplastic transformation of Pik3ca^H1047R-induced vascular malformation in a mouse model

Miaolu Tang, Jessica Sallavanti, Matthew Lanza, Danielle Covington, Wei Li

published 04 May 2026

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Low ALDH1A1 expression in relation to nodal metastasis and survival in tongue squamous cell carcinoma

Sarina Moradianlotfi, Tahere Yousefi, Afsaneh Goudarzi, Ahmad Reza Shamshiri, Samira Derakhshan

published 10 Apr 2026

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Context-dependent dysregulation of store-operated calcium channels in head and neck squamous cell carcinoma

Heba Ghozlan, Saja Al-Malahmeh, Othman Al-Shboul, Anas J. Mistareehi, Lina Elsalem

published 09 Mar 2026

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A biologically constrained agent-based model of cancer stem cell dynamics with reinforcement learning-guided adaptive radiotherapy

Mina Lagzian, S. Ehsan Razavi, Reyhane Kardehi Moghaddam

published 05 Feb 2026

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WNK2 may promote ovarian cancer progression by upregulating POU5F1B

Fengjie Li, Yongqin Jia, Xiaoli Min, Pangyang Zhang, Yudi Li, Deng Li, Lanqin Cao, Yanzhou Wang, Zhiqing Liang

published 02 Feb 2026

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Prediction of myeloid malignant cells in Fanconi anemia using machine learning

Luis A. Flores-Mejía, Pablo Siliceo, Ulises Juárez Figueroa, Angel A. De la Cruz, Cecilia Ayala-Zambrano, Hugo Tovar, Sara Frías, Alfredo Rodríguez

published 20 Jan 2026

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Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies

Burhan Ul Haq, Shazia Sofi, Hina Qayoom, Nusrat Jan, Asma Jan, Mohammad Aljasir, Irshad Ahmad, Abdullah Almilabairy, Fuzail Ahmad, Bader Alshehri, Manzoor Ahmad Mir

published 05 Dec 2025

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A protocol for using human genetic data to identify circulating protein level changes that are the causal consequence of cancer processes

Lisa M. Hobson, Richard M. Martin, Karl Smith-Byrne, George Davey Smith, Gibran Hemani, Joseph H. Gilbody, James Yarmolinsky, Sarah E.R. Bailey, Lucy J. Goudswaard, Philip C. Haycock

published 05 Dec 2025

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N-glycosylation of NANOG regulates stemness and apoptosis in colon cancer cells

Yin Tian, Yu Zeng, Yun Liu, Jun Ye, Xin Zhang

published 20 Nov 2025

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In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen – 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima

Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage, Prabudhi S. Garusinghe, Damith Chathuranga, Vinoda D. Athukorala, Ashein Kothalawala, Asirini H. Jayasekara, Rajitha K. Rathnayaka, Umanda Anjalee De Silva, Mohamed Faries, Thimali H. Weragoda, Shalini K. Wijerathne, Umapriyatharshini Rajagopalan, Kanishka S. Senathilake, Kamani H. Tennekoon, Achyut Adhikari, Sameera R. Samarakoon

published 03 Nov 2025

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STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells

Wei Ni Yew, Christopher James Dean, Dedrick Kok Hong Chan

published 15 Oct 2025

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The role of lncRNA SNHG15 in UV-induced DNA damage repair

Xin Zhang, Jiahui Lin, Zixuan Fan, Sai Zhang, Meiqi Yang, Tingting Zhu, Qing Lu, Yuming Wang

published 09 Oct 2025

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Frizzled 7 drives amplification of cancer stem-cell subpopulations and the aggressiveness and poor differentiation of human hepatocellular carcinoma

Anaïs Lopez, Alexia Paturel, Nadim Fares, Floriane Pez, Guanxiong Wang, Patricia Gifu, Lydie Lefrançois, Jihed Chouaref, Pierre Saintigny, Janick Selves, Jean-Marie Peron, Michel Rivoire, Philippe Merle, Claude Caron de Fromentel

published 07 Oct 2025

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