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Binding analysis

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718

Mie Andersen, Dorte Nørgaard-Pedersen, Jakob Brandt, Ingrid Pettersson, Rita Slaaby

published 01 Jun 2017

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Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP)

Anyango D. Kamina, Noreen Williams

published 18 May 2017

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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

Sylwia Huber, Fabio Casagrande, Melanie N. Hug, Lisha Wang, Philipp Heine, Lutz Kummer, Andreas Plückthun, Michael Hennig

published 16 May 2017

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Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

Ornella Di Pietro, Jordi Juárez-Jiménez, Diego Muñoz-Torrero, Charles A. Laughton, F. Javier Luque

published 15 May 2017

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A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81

Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo, Je-Wen Liou

published 08 May 2017

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Citrullination only infrequently impacts peptide binding to HLA class II MHC

John Sidney, Stephane Becart, Mimi Zhou, Karen Duffy, Mikaela Lindvall, Erin C. Moore, Eugene L. Moore, Tadimeti Rao, Navin Rao, Morten Nielsen, Bjoern Peters, Alessandro Sette

published 08 May 2017

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Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme

Jiang-Ke Yang, Wei Xiong, Fang-Yuan Chen, Li Xu, Zheng-Gang Han

published 05 May 2017

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Molecular docking studies of 3-bromopyruvate and its derivatives to metabolic regulatory enzymes: Implication in designing of novel anticancer therapeutic strategies

Saveg Yadav, Shrish Kumar Pandey, Vinay Kumar Singh, Yugal Goel, Ajay Kumar, Sukh Mahendra Singh

published 02 May 2017

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Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A. Landon, Tariq Bashir, Michael E. Jung, Alan Lichtenstein, Joseph Gera

published 28 Apr 2017

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Mini-G proteins: Novel tools for studying GPCRs in their active conformation

Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C. Edwards, Courtney F. White, Haijuan Du, Reinhard Grisshammer, Christopher G. Tate

published 20 Apr 2017

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Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

Anneleen Van Hout, Thomas D’huys, Merel Oeyen, Dominique Schols, Tom Van Loy

published 14 Apr 2017

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In-depth study of DNA binding of Cys₂His₂ finger domains in testis zinc-finger protein

Chun-Chi Chou, Shu-Yi Wei, Yuan-Chao Lou, Chinpan Chen

published 06 Apr 2017

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Inhibition of prenylated KRAS in a lipid environment

Johanna M. Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D. Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P. Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy

published 06 Apr 2017

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