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Basic cancer research

A randomised pilot trial of perioperative propranolol combined with celecoxib versus standard of care in stage III melanoma: The ProCel study protocol

Katina J. Selvaraj, Diona L. Damian, J. Guy Lyons, James S. Wilmott, Peter M. Ferguson, Michele McGrady, Iris Bartula, Serigne N. Lo, Richard A. Scolyer, Angela L. Ferguson, Robyn P.M. Saw

published 29 Jan 2026

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The impact of macrophage infiltration on [¹⁸F]FDG PET accuracy in identifying mediastinal and abdominal lymph node metastases: A retrospective cohort study

Jing Wei, Weijing Tao, Tianshuo Yang, Jie Dong

published 23 Jan 2026

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Secretory leukocyte protease inhibitor (SLPI) promotes cholangiocarcinoma progression via inflammation-associated and vasculogenic mechanisms

Kangsadan Chueajedton, Chaiwat Chueaiphuk, Jeranan Inpad, Sarawut Kumphune, Worasak Kaewkong, Damratsamon Surangkul, Kanlayanee Sawanyawisuth, Ubon Cha’on, Suchada Phimsen

published 20 Jan 2026

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Combination of ultrasonography and MRI for preoperative prediction of lymph node metastasis in tongue squamous cell carcinoma: An exploratory study

Hiroshi Hijioka, Hiroaki Tabata

published 16 Jan 2026

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Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer

Di Zhou, Junjun Zhou, Bin Hu, Yinjue Yu, Yuhai Bian, Cuiping Yang, Yongrui Bai, Haiyan Chen

published 13 Jan 2026

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Mechanochemical interactions in cancer cells: The role of substrate stiffness in cell behavior and drug response

Sayed Reza Ramezani, Afsaneh Mojra, Mohammad Tafazzoli-Shadpour

published 07 Jan 2026

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Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer

Kestutis Urbonas, Gabija Stachneviciute, Aldona Jasukaitiene, Povilas Ignatavicius, Zilvinas Dambrauskas, Antanas Gulbinas, Giedrius Barauskas

published 02 Jan 2026

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Experiences and needs of patients facing incurable cancer and their relatives with informal care in psychosocial supporting centres in the Netherlands: A qualitative study

Suzanne D. Siemelink, Julia van Koeveringe, Monique Bussmann, Saskia van Veen, Sandrina Sangers, Natasja J.H. Raijmakers

published 02 Jan 2026

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Clinicopathological characteristics and prognosis analysis of gastrinoma based on the SEER database

Chenjian Qiu, Chengru Hu, Chengjie Lu, Jingxian Shi, Zhenguo Qiao, Yaping Wang, Feidie Xu

published 17 Dec 2025

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A multiple filter-wrapper feature selection algorithm based on process optimization mechanism for high-dimensional omics data analysis

Yongtao Shi, Yuefeng Zheng, Xiaotong Bai

published 11 Dec 2025

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Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies

Burhan Ul Haq, Shazia Sofi, Hina Qayoom, Nusrat Jan, Asma Jan, Mohammad Aljasir, Irshad Ahmad, Abdullah Almilabairy, Fuzail Ahmad, Bader Alshehri, Manzoor Ahmad Mir

published 05 Dec 2025

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Biologically-informed regional subset analysis with CatBoost for robust tissue-of-origin prediction

Sungmin Yang, Hong-Gee Kim

published 04 Dec 2025

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Low level of plasma DNase is associated with worse clinical outcome in testicular germ cell tumor patients and exogeneous DNase I improves cisplatin treatment efficacy

Michal Mego, Barbora Vlkova, Katarina Kalavska, Michal Pastorek, Zuzana Cierna, Zuzana Sestakova, Miroslav Chovanec, Natalia Udvorkova, Lucia Kucerova, Peter Celec

published 04 Dec 2025

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