August 2019

Erythema nodosum leprosum (ENL) manifesting as painful, erythematous lesions on the forearms of a patient with biopsy-proven lepromatous leprosy. This immunologically-mediated inflammatory reaction can develop abruptly and frequently recur despite effective treatment. A variety of neurologic and dermatologic pathologies can be seen months to years after initial diagnosis and treatment of underlying infection. Wellington and Schofield (2019)

Image Credit: Christina Schofield, MD

Editorial

DR Congo and Nigeria: New neglected tropical disease threats and solutions for the bottom 40%

Peter Hotez

PLOS Neglected Tropical Diseases: published August 8, 2019 | https://doi.org/10.1371/journal.pntd.0007145

Viewpoints

Building research capacity through “Planning for Success”

Ligia Gómez, Andrés Jaramillo, Beatrice Halpaap, Pascal Launois, Luis Gabriel Cuervo, Nancy Gore Saravia

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007426

Photo Quiz

A subcutaneous nodule in a returning Chinese expatriate

Xin-yu Wang, Qiao-ling Ruan, Peng Cui, Wen-hong Zhang

PLOS Neglected Tropical Diseases: published August 22, 2019 | https://doi.org/10.1371/journal.pntd.0007073

Reviews

Leptospira infection in rats: A literature review of global prevalence and distribution

Kenneth Boey, Kanae Shiokawa, Sreekumari Rajeev

PLOS Neglected Tropical Diseases: published August 9, 2019 | https://doi.org/10.1371/journal.pntd.0007499

Rickettsial infections of the central nervous system

Zuzana Sekeyová, Monika Danchenko, Peter Filipčík, Pierre Edouard Fournier

PLOS Neglected Tropical Diseases: published August 29, 2019 | https://doi.org/10.1371/journal.pntd.0007469

Research Articles

Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods

Johnny Vlaminck, Piet Cools, Marco Albonico, Shaali Ame, Mio Ayana, Giuseppe Cringoli, Daniel Dana, Jennifer Keiser, Maria P. Maurelli, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jozef Vercruysse, Jaco J. Verweij, Bruno Levecke

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007471

Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAK^G2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries

Piet Cools, Johnny Vlaminck, Marco Albonico, Shaali Ame, Mio Ayana, Barrios Perez José Antonio, Giuseppe Cringoli, Daniel Dana, Jennifer Keiser, Maria P. Maurelli, Catalina Maya, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jaco J. Verweij, Jozef Vercruysse, Bruno Levecke

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007446

Induction of systemic, mucosal and memory antibody responses targeting Vibrio cholerae O1 O-specific polysaccharide (OSP) in adults following oral vaccination with an oral killed whole cell cholera vaccine in Bangladesh

Aklima Akter, Pinki Dash, Amena Aktar, Sultana Rownok Jahan, Sadia Afrin, Salima Raiyan Basher, Al Hakim, Asura Khanam Lisa, Fahima Chowdhury, Ashraful I. Khan, Peng Xu, Richelle C. Charles, Meagan Kelly, Pavol Kováč, Jason B. Harris, Taufiqur Rahman Bhuiyan, Stephen B. Calderwood, Edward T. Ryan, Firdausi Qadri

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007634

Socio-spatial heterogeneity in participation in mass dog rabies vaccination campaigns, Arequipa, Peru

Ricardo Castillo-Neyra, Amparo M. Toledo, Claudia Arevalo-Nieto, Hannelore MacDonald, Micaela De la Puente-León, Cesar Naquira-Velarde, Valerie A. Paz-Soldan, Alison M. Buttenheim, Michael Z. Levy

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007600

Spatio-temporal distribution of Spiroplasma infections in the tsetse fly (Glossina fuscipes fuscipes) in northern Uganda

Daniela I. Schneider, Norah Saarman, Maria G. Onyango, Chaz Hyseni, Robert Opiro, Richard Echodu, Michelle O’Neill, Danielle Bloch, Aurélien Vigneron, T. J. Johnson, Kirstin Dion, Brian L. Weiss, Elizabeth Opiyo, Adalgisa Caccone, Serap Aksoy

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007340

Epidemiology, ecology and human perceptions of snakebites in a savanna community of northern Ghana

Yahaya Musah, Evans P. K. Ameade, Daniel K. Attuquayefio, Lars H. Holbech

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007221

Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study

Peter J. Halfmann, Amie J. Eisfeld, Tokiko Watanabe, Tadashi Maemura, Makoto Yamashita, Satoshi Fukuyama, Tammy Armbrust, Isaiah Rozich, Alhaji N’jai, Gabriele Neumann, Yoshihiro Kawaoka, Foday Sahr

PLOS Neglected Tropical Diseases: published August 1, 2019 | https://doi.org/10.1371/journal.pntd.0007654

Partial cross-protection between Japanese encephalitis virus genotype I and III in mice

Jianchao Wei, Xin Wang, Junjie Zhang, Shuang Guo, Linlin Pang, Kun Shi, Ke Liu, Donghua Shao, Yafeng Qiu, Lihong Liu, Frederik Widén, Beibei Li, Zhiyong Ma

PLOS Neglected Tropical Diseases: published August 2, 2019 | https://doi.org/10.1371/journal.pntd.0007601

Kankanet: An artificial neural network-based object detection smartphone application and mobile microscope as a point-of-care diagnostic aid for soil-transmitted helminthiases

Ariel Yang, Nahid Bakhtari, Liana Langdon-Embry, Emile Redwood, Simon Grandjean Lapierre, Patricia Rakotomanga, Armand Rafalimanantsoa, Juan De Dios Santos, Inès Vigan-Womas, Astrid M. Knoblauch, Luis A. Marcos

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007577

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

Marc P. Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J. Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W. von Geldern, Kennan Marsh, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward, Kenneth Pfarr, Dale J. Kempf, Achim Hoerauf

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007636

Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani

Humberto E. Ortega, Leonardo L. G. Ferreira, Weilan G. P. Melo, Ana Ligia L. Oliveira, René F. Ramos Alvarenga, Norberto P. Lopes, Tim S. Bugni, Adriano D. Andricopulo, Mônica T. Pupo

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007643

An evaluation of Brazil’s surveillance and prophylaxis of canine rabies between 2008 and 2017

Julio A. Benavides, Jane Megid, Aline Campos, Silene Rocha, Marco A. N. Vigilato, Katie Hampson

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007564

Integrated vector management with additional pre-transmission season thermal fogging is associated with a reduction in dengue incidence in Makassar, Indonesia: Results of an 8-year observational study

Isra Wahid, Hasanuddin Ishak, Abdul Hafid, Muhammad Fajri, Sukmawati Sidjal, Armin Nurdin, Naisyah Tun Azikin, Rusdyah Sudirman, Hajar Hasan, Muhammad Yusuf, Imam Bachtiar, William A. Hawley, Ronald Rosenberg, Neil F. Lobo

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007606

Projections of epidemic transmission and estimation of vaccination impact during an ongoing Ebola virus disease outbreak in Northeastern Democratic Republic of Congo, as of Feb. 25, 2019

Lee Worden, Rae Wannier, Nicole A. Hoff, Kamy Musene, Bernice Selo, Mathias Mossoko, Emile Okitolonda-Wemakoy, Jean Jacques Muyembe Tamfum, George W. Rutherford, Thomas M. Lietman, Anne W. Rimoin, Travis C. Porco, J. Daniel Kelly

PLOS Neglected Tropical Diseases: published August 5, 2019 | https://doi.org/10.1371/journal.pntd.0007512

Field assessment of insecticide dusting and bait station treatment impact against rodent flea and house flea species in the Madagascar plague context

Adélaïde Miarinjara, Soanandrasana Rahelinirina, Nadia Lova Razafimahatratra, Romain Girod, Minoarisoa Rajerison, Sebastien Boyer

PLOS Neglected Tropical Diseases: published August 6, 2019 | https://doi.org/10.1371/journal.pntd.0007604

eNose analysis of volatile chemicals from dogs naturally infected with Leishmania infantum in Brazil

Monica E. Staniek, Luigi Sedda, Tim D. Gibson, Cristian F. de Souza, Erika M. Costa, Rod J. Dillon, James G. C. Hamilton

PLOS Neglected Tropical Diseases: published August 6, 2019 | https://doi.org/10.1371/journal.pntd.0007599

An improved genome assembly of the fluke Schistosoma japonicum

Fang Luo, Mingbo Yin, Xiaojin Mo, Chengsong Sun, Qunfeng Wu, Bingkuan Zhu, Manyu Xiang, Jipeng Wang, Yi Wang, Jian Li, Ting Zhang, Bin Xu, Huajun Zheng, Zheng Feng, Wei Hu

PLOS Neglected Tropical Diseases: published August 7, 2019 | https://doi.org/10.1371/journal.pntd.0007612

Prolonged mosquitocidal activity of Siparuna guianensis essential oil encapsulated in chitosan nanoparticles

Taciano P. Ferreira, Khalid Haddi, Roberto F. T. Corrêa, Viviana L. B. Zapata, Tathyana B. Piau, Luis F. N. Souza, Swel-Marks G. Santos, Eugenio E. Oliveira, Luis O. V. Jumbo, Bergmann M. Ribeiro, Cesar K. Grisolia, Rodrigo R. Fidelis, Ana M. S. Maia, Raimundo W. S. Aguiar

PLOS Neglected Tropical Diseases: published August 9, 2019 | https://doi.org/10.1371/journal.pntd.0007624

Community-level epidemiology of soil-transmitted helminths in the context of school-based deworming: Baseline results of a cluster randomised trial on the coast of Kenya

Katherine E. Halliday, William E. Oswald, Carlos Mcharo, Emma Beaumont, Paul M. Gichuki, Stella Kepha, Stefan S. Witek-McManus, Sultani H. Matendechero, Hajara El-Busaidy, Redempta Muendo, Athuman N. Chiguzo, Jorge Cano, Mary W. Karanja, Leah W. Musyoka, Tuva K. Safari, Lennie N. Mutisya, Idris J. Muye, Maureen A. Sidigu, Roy M. Anderson, Elizabeth Allen, Simon J. Brooker, Charles S. Mwandawiro, Sammy M. Njenga, Rachel L. Pullan

PLOS Neglected Tropical Diseases: published August 9, 2019 | https://doi.org/10.1371/journal.pntd.0007427

Risk profiling of soil-transmitted helminth infection and estimated number of infected people in South Asia: A systematic review and Bayesian geostatistical Analysis

Ying-Si Lai, Patricia Biedermann, Akina Shrestha, Frédérique Chammartin, Natacha à Porta, Antonio Montresor, Nerges F. Mistry, Jürg Utzinger, Penelope Vounatsou

PLOS Neglected Tropical Diseases: published August 9, 2019 | https://doi.org/10.1371/journal.pntd.0007580

Progress towards lymphatic filariasis elimination in Ghana from 2000-2016: Analysis of microfilaria prevalence data from 430 communities

Nana Kwadwo Biritwum, Kwadwo K. Frempong, Suzanne Verver, Samuel Odoom, Bright Alomatu, Odame Asiedu, Periklis Kontoroupis, Abednego Yeboah, Edward Tei Hervie, Benjamin Marfo, Daniel A. Boakye, Sake J. de Vlas, John O. Gyapong, Wilma A. Stolk

PLOS Neglected Tropical Diseases: published August 9, 2019 | https://doi.org/10.1371/journal.pntd.0007115

Hantavirus host assemblages and human disease in the Atlantic Forest

Renata L. Muylaert, Ricardo Siqueira Bovendorp, Gilberto Sabino-Santos Jr, Paula R. Prist, Geruza Leal Melo, Camila de Fátima Priante, David A. Wilkinson, Milton Cezar Ribeiro, David T. S. Hayman

PLOS Neglected Tropical Diseases: published August 12, 2019 | https://doi.org/10.1371/journal.pntd.0007655

Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists

Shunyu Li, Jin-Ho Song, Tae Im Kim, Won Gi Yoo, Moo-Ho Won, Fuhong Dai, Sung-Jong Hong

PLOS Neglected Tropical Diseases: published August 13, 2019 | https://doi.org/10.1371/journal.pntd.0007573

Gambian human African trypanosomiasis in North West Uganda. Are we on course for the 2020 target?

Richard Selby, Charles Wamboga, Olema Erphas, Albert Mugenyi, Vincent Jamonneau, Charles Waiswa, Steve J. Torr, Michael Lehane

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007550

The Babesia observational antibody (BAOBAB) study: A cross-sectional evaluation of Babesia in two communities in Kilosa district, Tanzania

Evan M. Bloch, Zakayo Mrango, Mabula Kasubi, Jerusha Weaver, Aleksandra Mihailovic, Beatriz Munoz, Anna Weimer, Andrew Levin, Laura Tonnetti, Jeffrey M. Linnen, Vanessa Brès, Douglas E. Norris, Giovanna Carpi, Sheila K. West

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007632

Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

Agathe Chavy, Alessandra Ferreira Dales Nava, Sergio Luiz Bessa Luz, Juan David Ramírez, Giovanny Herrera, Thiago Vasconcelos dos Santos, Marine Ginouves, Magalie Demar, Ghislaine Prévot, Jean-François Guégan, Benoît de Thoisy

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007629

The prevalence of schistosomiasis in Uganda: A nationally representative population estimate to inform control programs and water and sanitation interventions

Natalie G. Exum, Simon P. S. Kibira, Ronald Ssenyonga, Julien Nobili, Alexandra K. Shannon, John C. Ssempebwa, Edridah M. Tukahebwa, Scott Radloff, Kellogg J. Schwab, Fredrick E. Makumbi

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007617

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

Lucie Danet, Guillaume Beauclair, Michèle Berthet, Gonzalo Moratorio, Ségolène Gracias, Frédéric Tangy, Valérie Choumet, Nolwenn Jouvenet

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007299

Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi

Rosangela Salerno-Goncalves, Darpan Kayastha, Alessio Fasano, Myron M. Levine, Marcelo B. Sztein

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007650

Progression of scarring trachoma in Tanzanian children: A four-year cohort study

Athumani M. Ramadhani, Tamsyn Derrick, David Macleod, Patrick Massae, Elias Mafuru, Aiweda Malisa, Kelvin Mbuya, Chrissy h. Roberts, William Makupa, Tara Mtuy, Robin L. Bailey, David C. W. Mabey, Martin J. Holland, Matthew J. Burton

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007638

Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi

Kelita Kamoto, Harry Noyes, Peter Nambala, Edward Senga, Janelisa Musaya, Benjamin Kumwenda, Bruno Bucheton, Annette Macleod, Anneli Cooper, Caroline Clucas, Christiane Herz-Fowler, Enock Matove, Arthur M. Chiwaya, John E. Chisi, for the TrypanoGEN Research Group as members of The H3Africa Consortium

PLOS Neglected Tropical Diseases: published August 14, 2019 | https://doi.org/10.1371/journal.pntd.0007603

Systematic review on antigens for serodiagnosis of visceral leishmaniasis, with a focus on East Africa

Vera Kühne, Zahra Rezaei, Paul Pitzinger, Philippe Büscher

PLOS Neglected Tropical Diseases: published August 15, 2019 | https://doi.org/10.1371/journal.pntd.0007658

The seasonality of diarrheal pathogens: A retrospective study of seven sites over three years

Dennis L. Chao, Anna Roose, Min Roh, Karen L. Kotloff, Joshua L. Proctor

PLOS Neglected Tropical Diseases: published August 15, 2019 | https://doi.org/10.1371/journal.pntd.0007211

Negligible exposure to nifurtimox through breast milk during maternal treatment for Chagas Disease

Samanta Moroni, Maria Elena Marson, Guillermo Moscatelli, Guido Mastrantonio, Margarita Bisio, Nicolas Gonzalez, Griselda Ballering, Jaime Altcheh, Facundo García-Bournissen

PLOS Neglected Tropical Diseases: published August 15, 2019 | https://doi.org/10.1371/journal.pntd.0007647

Relationship between treatment regimens for visceral leishmaniasis and development of post-kala-azar dermal leishmaniasis and visceral leishmaniasis relapse: A cohort study from Bangladesh

Dinesh Mondal, Amresh Kumar, Abhijit Sharma, Moshtaq Mural Ahmed, Md. Golam Hasnain, Abdul Alim, M. Mamun Huda, Ridwanur Rahman, Jorge Alvar, Be-Nazir Ahmed, Rashidul Haque

PLOS Neglected Tropical Diseases: published August 15, 2019 | https://doi.org/10.1371/journal.pntd.0007653

Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China

Bo Yi, Yi Chen, Xiao Ma, Jia Rui, Jing-An Cui, Haibin Wang, Jia Li, Soi-Fan Chan, Rong Wang, Keqin Ding, Lei Xie, Dongliang Zhang, Shuli Jiao, Xuying Lao, Yi-Chen Chiang, Yanhua Su, Benhua Zhao, Guozhang Xu, Tianmu Chen

PLOS Neglected Tropical Diseases: published August 15, 2019 | https://doi.org/10.1371/journal.pntd.0007659

Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India

Michaela Fakiola, Om Prakash Singh, Genevieve Syn, Toolika Singh, Bhawana Singh, Jaya Chakravarty, Shyam Sundar, Jenefer M. Blackwell

PLOS Neglected Tropical Diseases: published August 16, 2019 | https://doi.org/10.1371/journal.pntd.0007673

Wuchereria bancrofti infection is linked to systemic activation of CD4 and CD8 T cells

Inge Kroidl, Mkunde Chachage, Jonathan Mnkai, Anthony Nsojo, Myrna Berninghoff, Jaco J. Verweij, Lucas Maganga, Nyanda E. Ntinginya, Leonard Maboko, Petra Clowes, Michael Hoelscher, Elmar Saathoff, Christof Geldmacher

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007623

Vaccination coverage in the context of the emerging Yellow Fever threat in French Guiana

Claude Flamand, Sarah Bailly, Camille Fritzell, Sandrine Fernandes Pellerin, Alhassane Toure, Naïssa Chateau, Mona Saout, Sébastien Linares, Fabien Dubois, Laurent Filleul, Mirdad Kazanji

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007661

Late-onset ulnar neuritis following treatment of lepromatous leprosy infection

Trevor Wellington, Christina Schofield

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007684

Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging

Dennis J. Grab, Olga V. Nikolskaia, Bertrand Courtioux, Oriel M. M. Thekisoe, Stefan Magez, Maxim Bogorad, J. Stephen Dumler, Sylvie Bisser

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007631

The diagnosis of scabies by non-expert examiners: A study of diagnostic accuracy

Millicent H. Osti, Oliver Sokana, Christina Gorae, Margot J. Whitfeld, Andrew C. Steer, Daniel Engelman

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007635

Distribution of geographical scale, data aggregation unit and period in the correlation analysis between temperature and incidence of HFRS in mainland China: A systematic review of 27 ecological studies

Xing-Hua Bai, Cheng Peng, Tao Jiang, Zhu-Min Hu, De-Sheng Huang, Peng Guan

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007688

Is there a gap between health education content and practice toward schistosomiasis prevention among schoolchildren along the shores of Lake Victoria in Kenya?

Rie Takeuchi, Sammy M. Njenga, Yoshio Ichinose, Satoshi Kaneko, Crystal A. Estrada, Jun Kobayashi

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007572

Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection

Alexandra G. Fraga, Gabriela Trigo, Ramya K. Murthy, Shamim Akhtar, Madhavi Hebbur, Ana Rita Pacheco, Juan Dominguez, Rita Silva-Gomes, Carine M. Gonçalves, Hugo Oliveira, António G. Castro, Umender Sharma, Joana Azeredo, Jorge Pedrosa

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007113

Comparative and functional genomics of the protozoan parasite Babesia divergens highlighting the invasion and egress processes

Luis Miguel González, Karel Estrada, Ricardo Grande, Verónica Jiménez-Jacinto, Leticia Vega-Alvarado, Elena Sevilla, Jorge de la Barrera, Isabel Cuesta, Ángel Zaballos, José Manuel Bautista, Cheryl A. Lobo, Alejandro Sánchez-Flores, Estrella Montero

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007680

Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis

Fumika Mi-ichi, Takeshi Ishikawa, Vo Kha Tam, Sharmina Deloer, Shinjiro Hamano, Tsuyoshi Hamada, Hiroki Yoshida

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007633

Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand

Wen-Qiang He, Stephan Karl, Michael T. White, Wang Nguitragool, Wuelton Monteiro, Andrea Kuehn, Jakub Gruszczyk, Camila T. França, Jetsumon Sattabongkot, Marcus V. G. Lacerda, Wai-Hong Tham, Ivo Mueller

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007596

Ecology and seasonality of sandflies and potential reservoirs of cutaneous leishmaniasis in Ochollo, a hotspot in southern Ethiopia

Myrthe Pareyn, Emma Van den Bosch, Nigatu Girma, Natalie van Houtte, Stefan Van Dongen, Gert Van der Auwera, Fekadu Massebo, Simon Shibru, Herwig Leirs

PLOS Neglected Tropical Diseases: published August 19, 2019 | https://doi.org/10.1371/journal.pntd.0007667

Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti

Shengzhang Dong, Seokyoung Kang, George Dimopoulos

PLOS Neglected Tropical Diseases: published August 20, 2019 | https://doi.org/10.1371/journal.pntd.0007681

Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis

Theresa B. Gallagher, Gabriela Mellado-Sanchez, Ana L. Jorgensen, Stephen Moore, James P. Nataro, Marcela F. Pasetti, Les W. Baillie

PLOS Neglected Tropical Diseases: published August 20, 2019 | https://doi.org/10.1371/journal.pntd.0007644

Detection of classic and cryptic Strongyloides genotypes by deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities

Meruyert Beknazarova, Joel L. N. Barratt, Richard S. Bradbury, Meredith Lane, Harriet Whiley, Kirstin Ross

PLOS Neglected Tropical Diseases: published August 20, 2019 | https://doi.org/10.1371/journal.pntd.0007241

Assessment of the new World Health Organization's dengue classification for predicting severity of illness and level of healthcare required

Balgees A. Ajlan, Maram M. Alafif, Maha M. Alawi, Naeema A. Akbar, Eman K. Aldigs, Tariq A. Madani

PLOS Neglected Tropical Diseases: published August 20, 2019 | https://doi.org/10.1371/journal.pntd.0007144

Complex interplay of evolutionary forces shaping population genomic structure of invasive Aedes albopictus in southern Europe

Verena Pichler, Panayiota Kotsakiozi, Beniamino Caputo, Paola Serini, Adalgisa Caccone, Alessandra della Torre

PLOS Neglected Tropical Diseases: published August 22, 2019 | https://doi.org/10.1371/journal.pntd.0007554

A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections

Jasmine Tyson, Wen-Yang Tsai, Jih-Jin Tsai, Ludvig Mässgård, Susan L. Stramer, Axel T. Lehrer, Vivek R. Nerurkar, Wei-Kung Wang

PLOS Neglected Tropical Diseases: published August 23, 2019 | https://doi.org/10.1371/journal.pntd.0007649

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya

Sheila B. Agha, David P. Tchouassi, Michael J. Turell, Armanda D. S. Bastos, Rosemary Sang

PLOS Neglected Tropical Diseases: published August 23, 2019 | https://doi.org/10.1371/journal.pntd.0007686

Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load

Michael Frimpong, Bernadette Agbavor, Mabel Sarpong Duah, Aloysius Loglo, Francisca N. Sarpong, Justice Boakye-Appiah, Kabiru M. Abass, Mathias Dongyele, George Amofa, Wilson Tuah, Margaret Frempong, Yaw A. Amoako, Mark Wansbrough-Jones, Richard O. Phillips

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007689

Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy

Tulika Singh, Cesar A. Lopez, Camila Giuberti, Maria L. Dennis, Hannah L. Itell, Holly J. Heimsath, Helen S. Webster, Hunter K. Roark, Paulo R. Merçon de Vargas, Allison Hall, Ralph G. Corey, Geeta K. Swamy, Reynaldo Dietze, Helen M. Lazear, Sallie R. Permar

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007648

Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean before and during the 2015–2016 Zika virus epidemic: A systematic review and meta-analysis

Ariadna Capasso, Danielle C. Ompad, Dorice L. Vieira, Annelies Wilder-Smith, Yesim Tozan

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007622

Loop-mediated Isothermal Amplification and nested PCR of the Internal Transcribed Spacer (ITS) for Histoplasma capsulatum detection

Matheus da Silva Zatti, Thales Domingos Arantes, José Alex Lourenço Fernandes, Mônica Baumgardt Bay, Eveline Pipolo Milan, Georggia Fatima Silva Naliato, Raquel Cordeiro Theodoro

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007692

Natural infection by Leishmania infantum in the Lutzomyia longipalpis population of an endemic coastal area to visceral leishmaniasis in Brazil is not associated with bioclimatic factors

Tiago Feitosa Mota, Orlando Marcos Farias de Sousa, Yuri de Jesus Silva, Lairton Souza Borja, Bruna Martins Macedo Leite, Manuela da Silva Solcà, Djalma Alves de Melo, Claudia Ida Brodskyn, Edelberto Santos Dias, Patrícia Sampaio Tavares Veras, Deborah Bittencourt Mothé Fraga

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007626

An investigation into the role of chronic Schistosoma mansoni infection on Human Papillomavirus (HPV) vaccine induced protective responses

Vicky Gent, Rebecca Waihenya, Lucy Kamau, Ruth Nyakundi, Peris Ambala, Thomas Kariuki, Lucy Ochola

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007704

Macropinocytosis dependent entry of Chikungunya virus into human muscle cells

Ching Hua, Regina Lee, Khairunnisa Mohamed Hussain, Justin Jang Hann Chu

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007610

Amblyomma americanum serpin 27 (AAS27) is a tick salivary anti-inflammatory protein secreted into the host during feeding

Lucas Tirloni, Tae Kwon Kim, Markus Berger, Carlos Termignoni, Itabajara da Silva Vaz Jr., Albert Mulenga

PLOS Neglected Tropical Diseases: published August 26, 2019 | https://doi.org/10.1371/journal.pntd.0007660

Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach

Aline Kuhn Sbruzzi Pasquali, Rafael Antunes Baggio, Walter Antonio Boeger, Nilsa González-Britez, Deborah Carbonera Guedes, Enmanuel Céspedes Chaves, Vanete Thomaz-Soccol

PLOS Neglected Tropical Diseases: published August 29, 2019 | https://doi.org/10.1371/journal.pntd.0007639

Longitudinal follow up of serological response in children treated for Chagas disease

Guillermo Moscatelli, Samanta Moroni, Facundo García Bournissen, Nicolás González, Griselda Ballering, Alejandro Schijman, Ricardo Corral, Margarita Bisio, Héctor Freilij, Jaime Altcheh

PLOS Neglected Tropical Diseases: published August 29, 2019 | https://doi.org/10.1371/journal.pntd.0007668

Sindbis virus polyarthritis outbreak signalled by virus prevalence in the mosquito vectors

Jan O. Lundström, Jenny C. Hesson, Martina L. Schäfer, Örjan Östman, Torsten Semmler, Michaël Bekaert, Manfred Weidmann, Åke Lundkvist, Martin Pfeffer

PLOS Neglected Tropical Diseases: published August 29, 2019 | https://doi.org/10.1371/journal.pntd.0007702

The Accuracy of Histopathological and Cytopathological Techniques in the Identification of the Mycetoma Causative Agents

Emmanuel Edwar Siddig, Najwa Adam Mhmoud, Sahar Mubarak Bakhiet, Omnia Babekir Abdallah, Salwa Osman Mekki, Nadia I. El Dawi, Wendy Van de Sande, Ahmed Hassan Fahal

PLOS Neglected Tropical Diseases: published August 29, 2019 | https://doi.org/10.1371/journal.pntd.0007056

A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection

Natalia E. Jiménez, Ziomara P. Gerdtzen, Álvaro Olivera-Nappa, J. Cristian Salgado, Carlos Conca

PLOS Neglected Tropical Diseases: published August 30, 2019 | https://doi.org/10.1371/journal.pntd.0007678

Cover