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Table of Contents

January 2008

Cover

Fluorescent Hookworm
Issue Image

Infective third-stage larvae of the dog hookworm, Ancylostoma caninum, can be tricked into thinking they have infected a mammalian host by adding serum during in vitro culture, by a process called "activation." This image shows ingestion of fluorescein-tagged serum albumin by activated A. caninum larvae, causing the intestine of the worm to fluoresce. In this issue of PLoS Neglected Tropical Diseases, Bennett Datu and colleagues describe the genes that are upregulated by hookworm larvae during the transition from a free-living to a parasitic state (see Datu et al., e130).

Image Credit: Bennett Datu

Editorial

The Giant Anteater in the Room: Brazil's Neglected Tropical Diseases Problem

Peter J. Hotez

PLOS Neglected Tropical Diseases: published January 30, 2008 | https://doi.org/10.1371/journal.pntd.0000177

Expert Commentary

Molecular Studies in Treponema pallidum Evolution: Toward Clarity?

Connie J. Mulligan, Steven J. Norris, Sheila A. Lukehart

PLOS Neglected Tropical Diseases: published January 23, 2008 | https://doi.org/10.1371/journal.pntd.0000184

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  2. On the Origin of the Treponematoses: A Phylogenetic Approach

Historical Profiles and Perspectives

The Stigmatization of Leprosy in India and Its Impact on Future Approaches to Elimination and Control

Jesse T. Jacob, Carlos Franco-Paredes

PLOS Neglected Tropical Diseases: published January 30, 2008 | https://doi.org/10.1371/journal.pntd.0000113

Research Articles

Characterization of the Entamoeba histolytica Ornithine Decarboxylase-Like Enzyme

Anupam Jhingran, Prasad K. Padmanabhan, Sushma Singh, Krishanpal Anamika, Abhijeet A. Bakre, Sudha Bhattacharya, Alok Bhattacharya, Narayanaswamy Srinivasan, Rentala Madhubala

PLOS Neglected Tropical Diseases: published January 2, 2008 | https://doi.org/10.1371/journal.pntd.0000115

An Oral Recombinant Vaccine in Dogs against Echinococcus granulosus, the Causative Agent of Human Hydatid Disease: A Pilot Study

Anne-Francoise Petavy, Carlos Hormaeche, Samia Lahmar, Hammou Ouhelli, Alejandro Chabalgoity, Thierry Marchal, Samira Azzouz, Fernanda Schreiber, Gabriela Alvite, Marie-Elisabeth Sarciron, Duncan Maskell, Adriana Esteves, Georges Bosquet

PLOS Neglected Tropical Diseases: published January 16, 2008 | https://doi.org/10.1371/journal.pntd.0000125

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  1. Correction: An oral recombinant vaccine in dogs against Echinococcus granulosus, the causative agent of human hydatid disease: A pilot study

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Anton Simeonov, Ajit Jadhav, Ahmed A. Sayed, Yuhong Wang, Michael E. Nelson, Craig J. Thomas, James Inglese, David L. Williams, Christopher P. Austin

PLOS Neglected Tropical Diseases: published January 2, 2008 | https://doi.org/10.1371/journal.pntd.0000127

Interspecific Hybridization Yields Strategy for South Pacific Filariasis Vector Elimination

Corey L. Brelsfoard, Yves Séchan, Stephen L. Dobson

PLOS Neglected Tropical Diseases: published January 16, 2008 | https://doi.org/10.1371/journal.pntd.0000129

Transcriptional Changes in the Hookworm, Ancylostoma caninum, during the Transition from a Free-Living to a Parasitic Larva

Bennett J. D. Datu, Robin B. Gasser, Shivashankar H. Nagaraj, Eng K. Ong, Peter O'Donoghue, Russell McInnes, Shoba Ranganathan, Alex Loukas

PLOS Neglected Tropical Diseases: published January 9, 2008 | https://doi.org/10.1371/journal.pntd.0000130

Strongyloides ratti: In Vitro and In Vivo Activity of Tribendimidine

Jennifer Keiser, Kai Thiemann, Yvette Endriss, Jürg Utzinger

PLOS Neglected Tropical Diseases: published January 23, 2008 | https://doi.org/10.1371/journal.pntd.0000136

Helminthiasis and Hygiene Conditions of Schools in Ikenne, Ogun State, Nigeria

Uwem Friday Ekpo, Simon Nnayere Odoemene, Chiedu Felix Mafiana, Sammy Olufemi Sam-Wobo

PLOS Neglected Tropical Diseases: published January 30, 2008 | https://doi.org/10.1371/journal.pntd.0000146

On the Origin of the Treponematoses: A Phylogenetic Approach

Kristin N. Harper, Paolo S. Ocampo, Bret M. Steiner, Robert W. George, Michael S. Silverman, Shelly Bolotin, Allan Pillay, Nigel J. Saunders, George J. Armelagos

PLOS Neglected Tropical Diseases: published January 15, 2008 | https://doi.org/10.1371/journal.pntd.0000148

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Household Transmission of Leptospira Infection in Urban Slum Communities

Elves A. P. Maciel, Ana Luiza F. de Carvalho, Simone F. Nascimento, Rosan B. de Matos, Edilane L. Gouveia, Mitermayer G. Reis, Albert I. Ko

PLOS Neglected Tropical Diseases: published January 30, 2008 | https://doi.org/10.1371/journal.pntd.0000154

Triple Co-Administration of Ivermectin, Albendazole and Praziquantel in Zanzibar: A Safety Study

Khalfan A. Mohammed, Hamad J. Haji, Albis-Francesco Gabrielli, Likezo Mubila, Gautam Biswas, Lester Chitsulo, Mark H. Bradley, Dirk Engels, Lorenzo Savioli, David H. Molyneux

PLOS Neglected Tropical Diseases: published January 23, 2008 | https://doi.org/10.1371/journal.pntd.0000171