Table of Contents

January 2008

Infective third-stage larvae of the dog hookworm, Ancylostoma caninum, can be tricked into thinking they have infected a mammalian host by adding serum during in vitro culture, by a process called "activation." This image shows ingestion of fluorescein-tagged serum albumin by activated A. caninum larvae, causing the intestine of the worm to fluoresce. In this issue of PLoS Neglected Tropical Diseases, Bennett Datu and colleagues describe the genes that are upregulated by hookworm larvae during the transition from a free-living to a parasitic state (see Datu et al., e130).

Image Credit: Bennett Datu


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