Figures
Dengue virus is unable to productively infect dermal-type macrophages.
The image shows a human CD209+ macrophage, in which the dengue virus envelope E protein, fused to green fluorescent protein, is not co-localized with the acidic (red) perinuclear compartments. Envelope acidification is critical to initiate the viral life cycle. IL-10, present in the human skin, is required for the formation of these macrophages. Understanding these infection events shortly after the mosquito bite can help explain why many dengue infections are asymptomatic (see Kwan et al., doi:10.1371/journal.pntd.0000311).
Image Credit: Marion Decossas, Erika Navarro-Sanchez, and Hélène Dumortier
Citation: (2008) PLoS Neglected Tropical Diseases Issue Image | Vol. 2(10) October 2008. PLoS Neglect Trop Dis 2(10): ev02.i10. https://doi.org/10.1371/image.pntd.v02.i10
Published: October 29, 2008
Copyright: © 2008 Decossas et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The image shows a human CD209+ macrophage, in which the dengue virus envelope E protein, fused to green fluorescent protein, is not co-localized with the acidic (red) perinuclear compartments. Envelope acidification is critical to initiate the viral life cycle. IL-10, present in the human skin, is required for the formation of these macrophages. Understanding these infection events shortly after the mosquito bite can help explain why many dengue infections are asymptomatic (see Kwan et al., doi:10.1371/journal.pntd.0000311).
Image Credit: Marion Decossas, Erika Navarro-Sanchez, and Hélène Dumortier