Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi

• Isabel S. Shiratsubaki ,

  Contributed equally to this work with: Isabel S. Shiratsubaki, Xin Fang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, United States of America, Department of Bioengineering, UC San Diego, La Jolla, California, United States of America

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• Xin Fang ,

  Contributed equally to this work with: Isabel S. Shiratsubaki, Xin Fang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering, UC San Diego, La Jolla, California, United States of America

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• Rodolpho O. O. Souza,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Biochemistry of Tryps - LaBTryps, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil

  http://orcid.org/0000-0003-1215-8553

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• Bernhard O. Palsson,

  Roles Conceptualization, Funding acquisition, Resources, Software

  Affiliations Department of Bioengineering, UC San Diego, La Jolla, California, United States of America, Department of Pediatrics, UC San Diego, La Jolla, California, United States of America, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

  http://orcid.org/0000-0003-2357-6785

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• Ariel M. Silber ,

  Roles Data curation, Funding acquisition, Investigation, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: asilber@usp.br (AMS); jairlage@health.ucsd.edu (JLS-N)

  Affiliation Laboratory of Biochemistry of Tryps - LaBTryps, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil

  http://orcid.org/0000-0003-4528-4732

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• Jair L. Siqueira-Neto

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: asilber@usp.br (AMS); jairlage@health.ucsd.edu (JLS-N)

  Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, United States of America

  http://orcid.org/0000-0001-9574-8174

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