The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

Anna Crisford; Ulrich Ebbinghaus-Kintscher; Eva Schoenhense; Achim Harder; Klaus Raming; Ita O’Kelly; Kelechi Ndukwe; Vincent O’Connor; Robert J. Walker; Lindy Holden-Dye

doi:10.1371/journal.pntd.0004062

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Open Access

Peer-reviewed

Research Article

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

Anna Crisford ,

Contributed equally to this work with: Anna Crisford, Ulrich Ebbinghaus-Kintscher

Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
⨯
Ulrich Ebbinghaus-Kintscher ,

Contributed equally to this work with: Anna Crisford, Ulrich Ebbinghaus-Kintscher

Affiliation Bayer CropScience Aktiengesellschaft, BCS AG-R&D-SMR-PC-PCB-PB, Monheim, Germany
⨯
Eva Schoenhense,

Current address: University of Bonn, Bonn, Germany

Affiliation Bayer CropScience Aktiengesellschaft, BCS AG-R&D-SMR-PC-PCB-PB, Monheim, Germany
⨯
Achim Harder,

Current address: Institute for Biology, Heinrich-Heine-University, Düsseldorf, Germany

Affiliation Bayer Animal Health GmbH, BHC-GDD-AH-PARA-AR, Monheim, Germany
⨯
Klaus Raming,

Affiliation Bayer CropScience Aktiengesellschaft, BCS AG-R&D-SMR-PC-PCB-PB, Monheim, Germany
⨯
Ita O’Kelly,

Affiliation Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom
⨯
Kelechi Ndukwe,

Current address: Department of Biological Sciences, Lehman College, City University of New York, West Bronx, New York, New York, United States of America

Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
⨯
Vincent O’Connor,

Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
⨯
Robert J. Walker,

Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
⨯
Lindy Holden-Dye

* E-mail: lmhd@soton.ac.uk

Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
⨯

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

Anna Crisford,
Ulrich Ebbinghaus-Kintscher,
Eva Schoenhense,
Achim Harder,
Klaus Raming,
Ita O’Kelly,
Kelechi Ndukwe,
Vincent O’Connor,
Robert J. Walker,
Lindy Holden-Dye

Published: October 5, 2015
https://doi.org/10.1371/journal.pntd.0004062

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