Raising the bar for causal inference: PLOS Medicine adopts the TARGET guidelines for target trial emulation studies

Helen Lumbard, on behalf of the PLOS Medicine Staff Editors

PLOS Medicine: published October 31, 2025 | https://doi.org/10.1371/journal.pmed.1004796

Why psychiatric bed capacity varies widely: Strategic questions on global mental health

Akihiro Seita

PLOS Medicine: published October 10, 2025 | https://doi.org/10.1371/journal.pmed.1004761

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Improving reporting of observational studies of interventions: The TARGET guideline

Harrison J. Hansford, James H. McAuley, Aidan G. Cashin

PLOS Medicine: published October 15, 2025 | https://doi.org/10.1371/journal.pmed.1004787

Open science must include effective results dissemination to study participants

Ka Hin Tai, Gérard Legoff, Anne Le Louarn, Nchangwi Syntia Munung, Florian Naudet

PLOS Medicine: published October 15, 2025 | https://doi.org/10.1371/journal.pmed.1004780

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Heart failure diagnosis: Impacts of atrial fibrillation on the diagnostic marker NT-proBNP

Yang Chen, Garry McDowell, Gregory Y. H. Lip

PLOS Medicine: published October 31, 2025 | https://doi.org/10.1371/journal.pmed.1004782

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Changes in child mortality and population health following 10 years of health systems strengthening in rural Madagascar: A longitudinal cohort study

Andres Garchitorena, Ann C. Miller, Hobisoa L. Razanadranaivo, Luc Rakotonirina, Sarah-Anne Barriault, Benedicte Razafinjato, Jacques Aubin Kotchofa, Feno Rafenoarimalala, Rado J. L. Rakotonanahary, Felana A. Ihantamalala, Michelle V. Evans, Andoniaina Tojoharimanda Tolojananahary, Vero Ramanandraitsiory, Andriatiana Tsitinomen’nyaina, Fiainamirindra Anjaratiana Ralaivavikoa, Estelle M. Raza-Fanomezanjanahary, Marius Randriamanambintsoa, Samuel Andrianambinina, Lethicia Lydia Yasmine, Megan B. Murray, Michael L. Rich, Laura F. Cordier, Karen E. Finnegan, Matthew H. Bonds, Zely Arivelo Randriamanantany

PLOS Medicine: published October 7, 2025 | https://doi.org/10.1371/journal.pmed.1004549

Zinc as adjunct treatment for clinical severe infection in young infants: A randomized double-blind placebo-controlled trial in India and Nepal

Nitya Wadhwa, Antara Sinha, Sudha Basnet, Sugandha Arya, Raghvendra Singh, Mamta Jajoo, Ayushi, Dharmendra Sharma, Ajay Kumar, Harish K. Pemde, Varinder Singh, Ram H. Chapagain, Anuradha Govil, Debjani R. Purakayastha, Ganesh P. Shah, Medha Mittal, Laxman P. Shrestha, Harish Chellani, Halvor Sommerfelt, Tor A. Strand, Shinjini Bhatnagar, the Zinc Sepsis Study Group

PLOS Medicine: published October 9, 2025 | https://doi.org/10.1371/journal.pmed.1004759

Comparative risk of post-acute sequelae following SARS-CoV-2 or influenza virus infection: A retrospective cohort study among United States adults

Joseph A. Lewnard, Debbie E. Malden, Vennis Hong, Jessica Skela, Leora R. Feldstein, Sharon Saydah, Iris Anne C. Reyes, Rulin Hechter, Lina S. Sy, Bradley K. Ackerson, Sara Y. Tartof

PLOS Medicine: published October 9, 2025 | https://doi.org/10.1371/journal.pmed.1004777

Immunogenicity and safety of DS-5670d, an omicron XBB.1.5-targeting COVID-19 mRNA vaccine: A phase 3, randomized, active-controlled study

Ami Kawamoto, Masahiro Hashida, Katsuyasu Ishida, Kei Furihata, Aisaku Ota, Kaori Takahashi, Sachiko Sakakibara, Takashi Nakano, Fumihiko Takeshita

PLOS Medicine: published October 13, 2025 | https://doi.org/10.1371/journal.pmed.1004499

Prognostic significance of CD8+ T cell Spatial Biomarkers in ER+ and ER− breast cancer: A retrospective cohort study

Andrew E. Walker, Xiaohua Gao, Qichen Wang, Gabriela De la Cruz, Didong Li, Charles M. Perou, Joel Saltz, James Steve Marron, Katherine A. Hoadley, Melissa A. Troester

PLOS Medicine: published October 15, 2025 | https://doi.org/10.1371/journal.pmed.1004647

Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study

Mengping Zhou, Henrik Larsson, Brian M. D’Onofrio, Mikael Landén, Ralf Kuja-Halkola, Zheng Chang, Isabell Brikell, Paul Lichtenstein, Erik Pettersson

PLOS Medicine: published October 21, 2025 | https://doi.org/10.1371/journal.pmed.1004784

Impact of excessive social media use on adolescent depression and its consequences in France: An individual-based microsimulation model

Nicolas Hoertel, Mark Olfson, Carlos Blanco, Margot Biscond, Frédéric Limosin, Marina Sánchez-Rico, Martin Blachier, Henri Leleu

PLOS Medicine: published October 21, 2025 | https://doi.org/10.1371/journal.pmed.1004737

Parental opioid prescriptions and the risk of opioid use in adolescents and young adults: The HUNT Study linked with prescription registry data

Anna Marcuzzi, Paulo Ferreira, Paul Jarle Mork, Manuela L. Ferreira, Karoline Moe, Sigmund Gismervik, Anne Lovise Nordstoga, Tom Ivar Lund Nilsen

PLOS Medicine: published October 23, 2025 | https://doi.org/10.1371/journal.pmed.1004763

Estimating the effect on obesity of delaying tax-based interventions in Mexico: A modeling study

Martha Carnalla, Francisco Reyes-Sánchez, Alexis Alonso-Bastida, Alan Reyes-García, Alessio Hernández-Rojas, C. Gabriela García, Isabel Junquera-Badilla, Ana Basto-Abreu, Boyd Swimburn, Juan A. Rivera, Tonatiuh Barrientos-Gutiérrez

PLOS Medicine: published October 23, 2025 | https://doi.org/10.1371/journal.pmed.1004769

Differences in growth trajectories in breastfed HIV-exposed uninfected and HIV-unexposed infants in Kenya: An observational cohort study

Ruchi Tiwari, Benson O. Singa, Priscah Lihanda, Mame M. Diakhate, Eric Ochola, Lucy Bunyige, Christina Sherry, Barbra A. Richardson, Dalton Wamalwa, Donna M. Denno, Grace C. John-Stewart, Grace M. Aldrovandi, Christine J. McGrath

PLOS Medicine: published October 27, 2025 | https://doi.org/10.1371/journal.pmed.1004781

Effectiveness of a brief intervention and text-based booster in the emergency department to reduce harmful and hazardous alcohol use: A pragmatic randomized adaptive clinical trial in Moshi, Tanzania

Catherine A. Staton, Linda Minja, Joao Vitor Perez de Souza, John A. Gallis, Pollyana Coelho Pessoa Santos, Mia Buono, Francis Sakita, Kennedy Ngowi, Judith Boshe, Ashley J. Phillips, Joao Ricardo Nickenig Vissoci, Blandina T. Mmbaga

PLOS Medicine: published October 27, 2025 | https://doi.org/10.1371/journal.pmed.1004548

NT-proBNP testing for heart failure diagnosis in people with atrial fibrillation: A diagnostic accuracy study

Nicholas R. Jones, Kathryn S. Taylor, José M. Ordóñez-Mena, Clare R. Goyder, F. D. Richard Hobbs, Clare J. Taylor

PLOS Medicine: published October 30, 2025 | https://doi.org/10.1371/journal.pmed.1004550

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Associations between epileptic seizures in pregnancy and adverse pregnancy outcomes: A systematic review and meta-analysis

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PLOS Medicine: published October 31, 2025 | https://doi.org/10.1371/journal.pmed.1004580

Correction: Vaccination strategies, public health impact and cost-effectiveness of dengue vaccine TAK-003: A modeling case study in Thailand

Jing Shen, Elizaveta Kharitonova, Anna Tytula, Justyna Zawieja, Samuel Aballea, Shibadas Biswal, Mayuri Sharma, Supattra Rungmaitree, Rosarin Sruamsiri, Derek Wallace, Riona Hanley

PLOS Medicine: published October 24, 2025 | https://doi.org/10.1371/journal.pmed.1004789

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