Cancer-associated venous thromboembolism (VTE) accounts for around 20% of all VTE cases and is a major cause of morbidity and mortality among individuals with cancer. Current guidelines typically recommend direct oral anticoagulants (DOACs) or low-molecular-weight heparin as first-line treatments for cancer-associated VTE. Because DOACs play a key role in preventing and treating cancer-associated VTE, interest in the effectiveness and safety of apixaban and rivaroxaban remains high. However, direct, head-to-head evidence comparing these two drugs in this population is lacking. In this issue, Jingjing Sun and colleagues examine the comparative effectiveness of apixaban and rivaroxaban in preventing recurrent VTE and reducing bleeding risk in individuals with active cancer.
Image Credit: Maksim Goncharenok, Pexels
Editorial
Open science and transparency are our strongest tools in the fight against fraudulent publishing activities
PLOS Medicine: published September 26, 2025 | https://doi.org/10.1371/journal.pmed.1004774
Perspectives
Ensuring the safety of newborns and children through community and healthcare actions
PLOS Medicine: published September 11, 2025 | https://doi.org/10.1371/journal.pmed.1004730
A need for new tools for prevention of malaria in pregnancy
PLOS Medicine: published September 19, 2025 | https://doi.org/10.1371/journal.pmed.1004729
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Policy Forum
Whose burden, whose benefit? Revisiting ethical trade-offs in the WHO guidelines on scaling up mass azithromycin administration
PLOS Medicine: published September 30, 2025 | https://doi.org/10.1371/journal.pmed.1004736
Research Articles
Fecal immunochemical test surveillance in colorectal cancer following adenoma resection: A longitudinal, population-based linked cohort study in China
PLOS Medicine: published September 2, 2025 | https://doi.org/10.1371/journal.pmed.1004687
Identifying care gaps along the HIV treatment failure cascade: A multistate analysis of viral load monitoring, re-suppression, and regimen switches in Zambia
PLOS Medicine: published September 3, 2025 | https://doi.org/10.1371/journal.pmed.1004720
Nonoperative treatment versus volar locking plating for distal radius fracture in patients aged 65 years or older (DRIFT trial): A randomized controlled trial
PLOS Medicine: published September 5, 2025 | https://doi.org/10.1371/journal.pmed.1004728
Vaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study
PLOS Medicine: published September 5, 2025 | https://doi.org/10.1371/journal.pmed.1004726
Adherence thresholds for emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis against HIV acquisition in cisgender women: A randomized directly observed dosing study
PLOS Medicine: published September 9, 2025 | https://doi.org/10.1371/journal.pmed.1004732
Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis
PLOS Medicine: published September 10, 2025 | https://doi.org/10.1371/journal.pmed.1004558
Machine learning algorithms and their predictive accuracy for suicide and self-harm: Systematic review and meta-analysis
PLOS Medicine: published September 11, 2025 | https://doi.org/10.1371/journal.pmed.1004581
Maternal-infant rotavirus-specific antibody kinetics to inform timing of vaccine boosting in Malawi: An observational study
PLOS Medicine: published September 12, 2025 | https://doi.org/10.1371/journal.pmed.1004734
Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia
PLOS Medicine: published September 15, 2025 | https://doi.org/10.1371/journal.pmed.1004711
Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study
PLOS Medicine: published September 15, 2025 | https://doi.org/10.1371/journal.pmed.1004727
The association of the planetary health diet with type 2 diabetes incidence and greenhouse gas emissions: Findings from the EPIC-Norfolk prospective cohort study
PLOS Medicine: published September 16, 2025 | https://doi.org/10.1371/journal.pmed.1004633
Prescribed opioid analgesic use in pregnancy and risk of neurodevelopmental disorders in children: A retrospective study in Sweden
PLOS Medicine: published September 16, 2025 | https://doi.org/10.1371/journal.pmed.1004721
Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study
PLOS Medicine: published September 17, 2025 | https://doi.org/10.1371/journal.pmed.1004731
Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda
PLOS Medicine: published September 18, 2025 | https://doi.org/10.1371/journal.pmed.1004582
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Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial
PLOS Medicine: published September 19, 2025 | https://doi.org/10.1371/journal.pmed.1004519
Association between lower fasting plasma glucose levels during oral glucose tolerance test and adverse perinatal outcomes: A Chinese cohort study
PLOS Medicine: published September 23, 2025 | https://doi.org/10.1371/journal.pmed.1004722
Carbon footprint of the Chinese healthcare service: An environmentally extended input–output analysis
PLOS Medicine: published September 24, 2025 | https://doi.org/10.1371/journal.pmed.1004738
Cyclone exposure and mortality risk of children under 5 years old: An observational study in 34 low- and middle-income countries
PLOS Medicine: published September 25, 2025 | https://doi.org/10.1371/journal.pmed.1004735
Comparative safety and effectiveness of apixaban and rivaroxaban for treatment of cancer-associated venous thromboembolism: A retrospective cohort study
PLOS Medicine: published September 26, 2025 | https://doi.org/10.1371/journal.pmed.1004754
Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study
PLOS Medicine: published September 26, 2025 | https://doi.org/10.1371/journal.pmed.1004765
Corrections
Correction: Estimating the proportion of clinically suspected cholera cases that are true Vibrio cholerae infections: A systematic review and meta-analysis
PLOS Medicine: published September 11, 2025 | https://doi.org/10.1371/journal.pmed.1004743
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Correction: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank
PLOS Medicine: published September 11, 2025 | https://doi.org/10.1371/journal.pmed.1004740
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Correction: Direct and indirect impacts of the COVID-19 pandemic on life expectancy and person-years of life lost with and without disability: A systematic analysis for 18 European countries, 2020–2022
PLOS Medicine: published September 19, 2025 | https://doi.org/10.1371/journal.pmed.1004757