The emergence of pathogenic bacteria that cannot be effectively treated with existing antimicrobials has been prioritised by the World Health Organization as one of the top ten global public health threats facing humanity. The burden of antimicrobial resistance (AMR) is disproportionately observed in low- and middle-income countries, particularly those in sub-Saharan Africa. Without intervention, it has been estimated that global deaths attributable to AMR could reach 10 million annually by 2050. Guest editors Timothy Walsh, Ramanan Laxminarayan, Ana Gales and PLOS Medicine editor, Philippa Dodd discuss the PLOS Medicine Special Issue dedicated to AMR. This collection of high-quality research articles defines the problem from a One Health perspective and highlights the multi-faceted challenges imposed by drug-resistant bacteria, the vast number of contributing factors, the consequences for health and economics, and interventions that could lessen the burden.
Image Credit: CDC, Unsplash
Editorial
Antimicrobial Resistance: Addressing a Global Threat to Humanity
PLOS Medicine: published July 3, 2023 | https://doi.org/10.1371/journal.pmed.1004264
Perspectives
Antimicrobial resistance: Strengthening surveillance for public health action
PLOS Medicine: published July 12, 2023 | https://doi.org/10.1371/journal.pmed.1004265
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Understanding the impact of antimicrobial resistance on outcomes of bloodstream infections in low- and middle-income countries
PLOS Medicine: published July 12, 2023 | https://doi.org/10.1371/journal.pmed.1004262
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Research Articles
Value of a catch-up HPV test in women aged 65 and above: A Danish population-based nonrandomized intervention study
PLOS Medicine: published July 6, 2023 | https://doi.org/10.1371/journal.pmed.1004253
Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
PLOS Medicine: published July 6, 2023 | https://doi.org/10.1371/journal.pmed.1004247
The potential impact of novel tuberculosis vaccine introduction on economic growth in low- and middle-income countries: A modeling study
PLOS Medicine: published July 11, 2023 | https://doi.org/10.1371/journal.pmed.1004252
The age profile of respiratory syncytial virus burden in preschool children of low- and middle-income countries: A semi-parametric, meta-regression approach
PLOS Medicine: published July 17, 2023 | https://doi.org/10.1371/journal.pmed.1004250
Paternal and maternal psychiatric history and risk of preterm and early term birth: A nationwide study using Swedish registers
PLOS Medicine: published July 20, 2023 | https://doi.org/10.1371/journal.pmed.1004256
Induction of labour at 39 weeks and adverse outcomes in low-risk pregnancies according to ethnicity, socioeconomic deprivation, and parity: A national cohort study in England
PLOS Medicine: published July 20, 2023 | https://doi.org/10.1371/journal.pmed.1004259
Effect of prenatal micronutrient-fortified balanced energy-protein supplementation on maternal and newborn body composition: A sub-study from the MISAME-III randomized controlled efficacy trial in rural Burkina Faso
PLOS Medicine: published July 24, 2023 | https://doi.org/10.1371/journal.pmed.1004242
Risk factors for inadequate and excessive gestational weight gain in 25 low- and middle-income countries: An individual-level participant meta-analysis
PLOS Medicine: published July 24, 2023 | https://doi.org/10.1371/journal.pmed.1004236
Incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong: A population-based cohort study
PLOS Medicine: published July 24, 2023 | https://doi.org/10.1371/journal.pmed.1004274
Analysis of bacterial vaginosis, the vaginal microbiome, and sexually transmitted infections following the provision of menstrual cups in Kenyan schools: Results of a nested study within a cluster randomized controlled trial
PLOS Medicine: published July 25, 2023 | https://doi.org/10.1371/journal.pmed.1004258
Corrections
Correction: Fortified balanced energy–protein supplementation during pregnancy and lactation and infant growth in rural Burkina Faso: A 2 × 2 factorial individually randomized controlled trial
PLOS Medicine: published July 17, 2023 | https://doi.org/10.1371/journal.pmed.1004267
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Correction: Collateral impacts of pandemic COVID-19 drive the nosocomial spread of antibiotic resistance: A modelling study
PLOS Medicine: published July 19, 2023 | https://doi.org/10.1371/journal.pmed.1004268