December 2021

Impacts of the ongoing COVID-19 pandemic on people and societies have been nothing short of disastrous, with serious and protracted consequences evident all around the world. Whilst strenuous efforts have been made to combat and mitigate the threats of SARS-CoV-2 infections for health and other domains of human wellbeing, the emergence of new virus variants has led to uncertainty about the potential risks of returning to normal patterns of social interactions, education and work, prolonging disruption and potentially exacerbating adverse effects. In a Perspective, Maya Peterson, Joshua Schwab and Diane Havlir discuss priorities for vaccination against SARS-CoV-2 in the United States and beyond.

Image Credit: torstensimon, Pixabay

Perspective

SARS-CoV-2 vaccine boosters: The time to act is now

Maya Petersen, Joshua Schwab, Diane V. Havlir

PLOS Medicine: published December 9, 2021 | https://doi.org/10.1371/journal.pmed.1003882

Research Articles

Hospital delivery and neonatal mortality in 37 countries in sub-Saharan Africa and South Asia: An ecological study

Anna D. Gage, Günther Fink, John E. Ataguba, Margaret E. Kruk

PLOS Medicine: published December 1, 2021 | https://doi.org/10.1371/journal.pmed.1003843

Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study

Göran Walldius, Ulf de Faire, Lars Alfredsson, Karin Leander, Peter Westerholm, Håkan Malmström, Torbjörn Ivert, Niklas Hammar

PLOS Medicine: published December 1, 2021 | https://doi.org/10.1371/journal.pmed.1003853

Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands

Esmée A. Bakker, Duck-chul Lee, Maria T. E. Hopman, Eline J. Oymans, Paula M. Watson, Paul D. Thompson, Dick H. J. Thijssen, Thijs. M. H. Eijsvogels

PLOS Medicine: published December 2, 2021 | https://doi.org/10.1371/journal.pmed.1003845

Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A cohort study

Shelly Karuna, Shuying Sue Li, Shannon Grant, Stephen R. Walsh, Ian Frank, Martin Casapia, Meg Trahey, Ollivier Hyrien, Leigh Fisher, Maurine D. Miner, April K. Randhawa, Laura Polakowski, James G. Kublin, Lawrence Corey, David Montefiori, for the HVTN 405/HPTN 1901 Study Team

PLOS Medicine: published December 6, 2021 | https://doi.org/10.1371/journal.pmed.1003868

Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June–July 2021: A population-based cross-sectional study

Manoj V. Murhekar, Tarun Bhatnagar, Jeromie Wesley Vivian Thangaraj, V. Saravanakumar, Muthusamy Santhosh Kumar, Sriram Selvaraju, Kiran Rade, C. P. Girish Kumar, R. Sabarinathan, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Jyothi Bhat, Debjit Chakraborty, Vishal Chopra, Dasarathi Das, Kangjam Rekha Devi, Gaurav Raj Dwivedi, Agam Jain, S. Muhammad Salim Khan, M. Sunil Kumar, Avula Laxmaiah, Major Madhukar, Amarendra Mahapatra, Talluri Ramesh, Chethana Rangaraju, Jyotirmayee Turuk, Suresh Yadav, Balram Bhargava, on behalf of the ICMR serosurveillance group

PLOS Medicine: published December 10, 2021 | https://doi.org/10.1371/journal.pmed.1003877

Assessing the relationship between agency and peer violence among adolescents aged 10 to 14 years in Kinshasa, Democratic Republic of Congo and Blantyre, Malawi: A cross-sectional study

Astha Ramaiya, Linnea Zimmerman, Eric Mafuta, Aimee Lulebo, Effie Chipeta, William Stones, Caroline Moreau

PLOS Medicine: published December 13, 2021 | https://doi.org/10.1371/journal.pmed.1003552

Completion of isoniazid–rifapentine (3HP) for tuberculosis prevention among people living with HIV: Interim analysis of a hybrid type 3 effectiveness–implementation randomized trial

Fred C. Semitala, Jillian L. Kadota, Allan Musinguzi, Juliet Nabunje, Fred Welishe, Anne Nakitende, Lydia Akello, Opira Bishop, Devika Patel, Amanda Sammann, Payam Nahid, Robert Belknap, Moses R. Kamya, Margaret A. Handley, Patrick P. J. Phillips, Anne Katahoire, Christopher A. Berger, Noah Kiwanuka, Achilles Katamba, David W. Dowdy, Adithya Cattamanchi

PLOS Medicine: published December 16, 2021 | https://doi.org/10.1371/journal.pmed.1003875

Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study

Laith J. Abu-Raddad, Hiam Chemaitelly, Houssein H. Ayoub, Peter Coyle, Joel A. Malek, Ayeda A. Ahmed, Yasmin A. Mohamoud, Shameem Younuskunju, Patrick Tang, Zaina Al Kanaani, Einas Al Kuwari, Adeel A. Butt, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F. Abdul Rahim, Gheyath K. Nasrallah, Hadi M. Yassine, Mohamed Ghaith Al Kuwari, Hamad Eid Al Romaihi, Mohamed H. Al-Thani, Abdullatif Al Khal, Roberto Bertollini

PLOS Medicine: published December 16, 2021 | https://doi.org/10.1371/journal.pmed.1003879

Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study

Mie Agermose Gram, Jens Nielsen, Astrid Blicher Schelde, Katrine Finderup Nielsen, Ida Rask Moustsen-Helms, Anne Katrine Bjørkholt Sørensen, Palle Valentiner-Branth, Hanne-Dorthe Emborg

PLOS Medicine: published December 17, 2021 | https://doi.org/10.1371/journal.pmed.1003874

Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study

Jonathon W. Senefeld, Patrick W. Johnson, Katie L. Kunze, Evan M. Bloch, Noud van Helmond, Michael A. Golafshar, Stephen A. Klassen, Allan M. Klompas, Matthew A. Sexton, Juan C. Diaz Soto, Brenda J. Grossman, Aaron A. R. Tobian, Ruchika Goel, Chad C. Wiggins, Katelyn A. Bruno, Camille M. van Buskirk, James R. Stubbs, Jeffrey L. Winters, Arturo Casadevall, Nigel S. Paneth, Beth H. Shaz, Molly M. Petersen, Bruce S. Sachais, Matthew R. Buras, Mikolaj A. Wieczorek, Benjamin Russoniello, Larry J. Dumont, Sarah E. Baker, Ralph R. Vassallo, John R. A. Shepherd, Pampee P. Young, Nicole C. Verdun, Peter Marks, N. Rebecca Haley, Robert F. Rea, Louis Katz, Vitaly Herasevich, Dan A. Waxman, Emily R. Whelan, Aviv Bergman, Andrew J. Clayburn, Mary Kathryn Grabowski, Kathryn F. Larson, Juan G. Ripoll, Kylie J. Andersen, Matthew N. P. Vogt, Joshua J. Dennis, Riley J. Regimbal, Philippe R. Bauer, Janis E. Blair, Zachary A. Buchholtz, Michaela C. Pletsch, Katherine Wright, Joel T. Greenshields, Michael J. Joyner, R. Scott Wright, Rickey E. Carter, DeLisa Fairweather

PLOS Medicine: published December 20, 2021 | https://doi.org/10.1371/journal.pmed.1003872

Corrections

Correction: Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study

Pradeep S. Chauhan, Kevin Chen, Ramandeep K. Babbra, Wenjia Feng, Nadja Pejovic, Armaan Nallicheri, Peter K. Harris, Katherine Dienstbach, Andrew Atkocius, Lenon Maguire, Faridi Qaium, Jeffrey J. Szymanski, Brian C. Baumann, Li Ding, Dengfeng Cao, Melissa A. Reimers, Eric H. Kim, Zachary L. Smith, Vivek K. Arora, Aadel A. Chaudhuri

PLOS Medicine: published December 14, 2021 | https://doi.org/10.1371/journal.pmed.1003876

Correction: Social determinants of mortality from COVID-19: A simulation study using NHANES

Benjamin Seligman, Maddalena Ferranna, David E. Bloom

PLOS Medicine: published December 29, 2021 | https://doi.org/10.1371/journal.pmed.1003888

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