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September 2018

Despite global commitments to improve maternal health, globally over 300,000 women still die each year during pregnancy, childbirth, or in the postpartum period. Many of these deaths are a result of indirect causes, e.g., infections, non-communicable diseases, and mental health disorders. In a Guest Editorial, James Beeson and colleagues discuss the importance of non-obstetric morbidity during pregnancy, and what needs to be done to address this global health challenge.

Image Credit: Pixnio.com

Editorial

Multiple morbidities in pregnancy: Time for research, innovation, and action

James G. Beeson, Caroline S. E. Homer, Christopher Morgan, Clara Menendez

Research Articles

Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case–control study

Xuehong Zhang, Megan Rice, Shelley S. Tworoger, Bernard A. Rosner, A. Heather Eliassen, Rulla M. Tamimi, Amit D. Joshi, Sara Lindstrom, Jing Qian, Graham A. Colditz, Walter C. Willett, Peter Kraft, Susan E. Hankinson

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts

Andrew S. P. Lim, Chris Gaiteri, Lei Yu, Shahmir Sohail, Walter Swardfager, Shinya Tasaki, Julie A. Schneider, Claire Paquet, Donald T. Stuss, Mario Masellis, Sandra E. Black, Jacques Hugon, Aron S. Buchman, Lisa L. Barnes, David A. Bennett, Philip L. De Jager

Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data

Haroon Ahmed, Daniel Farewell, Nick A. Francis, Shantini Paranjothy, Christopher C. Butler

Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study

Joshua A. Bell, Mark Hamer, Rebecca C. Richmond, Nicholas J. Timpson, David Carslake, George Davey Smith

Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study

Mélanie Deschasaux, Inge Huybrechts, Neil Murphy, Chantal Julia, Serge Hercberg, Bernard Srour, Emmanuelle Kesse-Guyot, Paule Latino-Martel, Carine Biessy, Corinne Casagrande, Mazda Jenab, Heather Ward, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Cecilie Kyrø, Anja Olsen, Aurélie Affret, Marie-Christine Boutron-Ruault, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Lukas Schwingshackl, Christina Bamia, Eleni Peppa, Antonia Trichopoulou, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Petra H. Peeters, Anette Hjartåker, Charlotta Rylander, Guri Skeie, J. Ramón Quirós, Paula Jakszyn, Elena Salamanca-Fernández, José María Huerta, Eva Ardanaz, Pilar Amiano, Ulrika Ericson, Emily Sonestedt, Ena Huseinovic, Ingegerd Johansson, Kay-Tee Khaw, Nick Wareham, Kathryn E. Bradbury, Aurora Perez-Cornago, Konstantinos K. Tsilidis, Pietro Ferrari, Elio Riboli, Marc J. Gunter, Mathilde Touvier

Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam, Tanzania

Pascal Geldsetzer, Joel M. Francis, David Sando, Gerda Asmus, Irene A. Lema, Eric Mboggo, Happiness Koda, Sharon Lwezaula, Ramya Ambikapathi, Wafaie Fawzi, Nzovu Ulenga, Till Bärnighausen

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

Miriam S. Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B. Cole, Joshua Chiou, Christopher D. Anderson on behalf of METASTROKE and the ISGC, Michael Boehnke, Markku Laakso, Gil Atzmon, Benjamin Glaser, Josep M. Mercader, Kyle Gaulton, Jason Flannick, Gad Getz, Jose C. Florez

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial

Brian Lawlor, Ricardo Segurado, Sean Kennelly, Marcel G. M. Olde Rikkert, Robert Howard, Florence Pasquier, Anne Börjesson-Hanson, Magda Tsolaki, Ugo Lucca, D. William Molloy, Robert Coen, Matthias W. Riepe, János Kálmán, Rose Anne Kenny, Fiona Cregg, Sarah O'Dwyer, Cathal Walsh, Jessica Adams, Rita Banzi, Laetitia Breuilh, Leslie Daly, Suzanne Hendrix, Paul Aisen, Siobhan Gaynor, Ali Sheikhi, Diana G. Taekema, Frans R. Verhey, Raffaello Nemni, Flavio Nobili, Massimo Franceschi, Giovanni Frisoni, Orazio Zanetti, Anastasia Konsta, Orologas Anastasios, Styliani Nenopoulou, Fani Tsolaki-Tagaraki, Magdolna Pakaski, Olivier Dereeper, Vincent de la Sayette, Olivier Sénéchal, Isabelle Lavenu, Agnès Devendeville, Gauthier Calais, Fiona Crawford, Michael Mullan, for the NILVAD Study Group

Variations in the quality of tuberculosis care in urban India: A cross-sectional, standardized patient study in two cities

Ada Kwan, Benjamin Daniels, Vaibhav Saria, Srinath Satyanarayana, Ramnath Subbaraman, Andrew McDowell, Sofi Bergkvist, Ranendra K. Das, Veena Das, Jishnu Das, Madhukar Pai

Delivery outcomes in term births after bariatric surgery: Population-based matched cohort study

Olof Stephansson, Kari Johansson, Jonas Söderling, Ingmar Näslund, Martin Neovius

Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

Kathleen L. Vincent, John A. Moss, Mark A. Marzinke, Craig W. Hendrix, Peter A. Anton, Richard B. Pyles, Kate M. Guthrie, Lauren Dawson, Trevelyn J. Olive, Irina Butkyavichene, Scott A. Churchman, John M. Cortez Jr, Rob Fanter, Manjula Gunawardana, Christine S. Miller, Flora Yang, Rochelle K. Rosen, Sara E. Vargas, Marc M. Baum