Dementia and aging populations—A global priority for contextualized research and health policy

Carol Brayne, Bruce Miller

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002275

Challenges and opportunities in understanding dementia and delirium in the acute hospital

Thomas A. Jackson, John R. F. Gladman, Rowan H. Harwood, Alasdair M. J. MacLullich, Elizabeth L. Sampson, Bart Sheehan, Daniel H. J. Davis

PLOS Medicine: published March 14, 2017 | https://doi.org/10.1371/journal.pmed.1002247

What’s the “Take Home” from Research on Dementia Trends?

Eric B. Larson, Kenneth M. Langa

PLOS Medicine: published March 7, 2017 | https://doi.org/10.1371/journal.pmed.1002236

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Rehabilitation for people living with dementia: A practical framework of positive support

Linda Clare

PLOS Medicine: published March 7, 2017 | https://doi.org/10.1371/journal.pmed.1002245

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

David A. Bennett

PLOS Medicine: published March 14, 2017 | https://doi.org/10.1371/journal.pmed.1002256

Dementia in the oldest old: Beyond Alzheimer disease

Aimee L. Pierce, Claudia H. Kawas

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002263

Dementia in low-income and middle-income countries: Different realities mandate tailored solutions

Cleusa Pinheiro Ferri, K. S. Jacob

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002271

Cultural representations of dementia

Alexandra Hillman, Joanna Latimer

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002274

Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem

Katherine L. Possin, Jennifer Merrilees, Stephen J. Bonasera, Alissa Bernstein, Winston Chiong, Kirby Lee, Leslie Wilson, Sarah M. Hooper, Sarah Dulaney, Tamara Braley, Sutep Laohavanich, Julie E. Feuer, Amy M. Clark, Michael W. Schaffer, A. Katrin Schenk, Julia Heunis, Paulina Ong, Kristen M. Cook, Angela D. Bowhay, Rosalie Gearhart, Anna Chodos, Georges Naasan, Andrew B. Bindman, Daniel Dohan, Christine Ritchie, Bruce L. Miller

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002260

Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data

Emma F. van Bussel, Edo Richard, Derk L. Arts, Astrid C. J. Nooyens, Preciosa M. Coloma, Margot W. M. de Waal, Marjan van den Akker, Marion C. J. Biermans, Markus M. J. Nielen, Kees van Boven, Hugo Smeets, Fiona E. Matthews, Carol Brayne, Wim B. Busschers, Willem A. van Gool, Eric P. Moll van Charante

PLOS Medicine: published March 7, 2017 | https://doi.org/10.1371/journal.pmed.1002235

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Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study

Raquel C. Gardner, Kenneth M. Langa, Kristine Yaffe

PLOS Medicine: published March 7, 2017 | https://doi.org/10.1371/journal.pmed.1002246

Multimorbidity and healthcare utilization among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort

Luke Mondor, Colleen J. Maxwell, David B. Hogan, Susan E. Bronskill, Andrea Gruneir, Natasha E. Lane, Walter P. Wodchis

PLOS Medicine: published March 7, 2017 | https://doi.org/10.1371/journal.pmed.1002249

Early diagnosis of mild cognitive impairment and mild dementia through basic and instrumental activities of daily living: Development of a new evaluation tool

Elise Cornelis, Ellen Gorus, Ingo Beyer, Ivan Bautmans, Patricia De Vriendt

PLOS Medicine: published March 14, 2017 | https://doi.org/10.1371/journal.pmed.1002250

Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study

Hui-Xin Wang, Stuart W. S. MacDonald, Serhiy Dekhtyar, Laura Fratiglioni

PLOS Medicine: published March 14, 2017 | https://doi.org/10.1371/journal.pmed.1002251

Effectiveness of an intervention to facilitate prompt referral to memory clinics in the United Kingdom: Cluster randomised controlled trial

Gill Livingston, Gianluca Baio, Andrew Sommerlad, Simon de Lusignan, Spyridon Poulimenos, Steve Morris, Greta Rait, Juanita Hoe

PLOS Medicine: published March 14, 2017 | https://doi.org/10.1371/journal.pmed.1002252

APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts

Jing Qian, Frank J. Wolters, Alexa Beiser, Mary Haan, M. Arfan Ikram, Jason Karlawish, Jessica B. Langbaum, John M. Neuhaus, Eric M. Reiman, J. Scott Roberts, Sudha Seshadri, Pierre N. Tariot, Beth McCarty Woods, Rebecca A. Betensky, Deborah Blacker

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002254

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

Rahul S. Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J. Schork, Howard J. Cabral, L. Adrienne Cupples, Wesley K. Thompson, Lilah Besser, Walter A. Kukull, Dominic Holland, Chi-Hua Chen, James B. Brewer, David S. Karow, Karolina Kauppi, Aree Witoelar, Celeste M. Karch, Luke W. Bonham, Jennifer S. Yokoyama, Howard J. Rosen, Bruce L. Miller, William P. Dillon, David M. Wilson, Christopher P. Hess, Margaret Pericak-Vance, Jonathan L. Haines, Lindsay A. Farrer, Richard Mayeux, John Hardy, Alison M. Goate, Bradley T. Hyman, Gerard D. Schellenberg, Linda K. McEvoy, Ole A. Andreassen, Anders M. Dale

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002258

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Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study

Linda Clare, Yu-Tzu Wu, Julia C. Teale, Catherine MacLeod, Fiona Matthews, Carol Brayne, Bob Woods, CFAS-Wales study team

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002259

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study

Darren M. Lipnicki, John D. Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole A. Kochan, Gavin Andrews, M. Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona E. Matthews, Blossom C. M. Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda C. W. Lam, Candy H. Y. Wong, Ada W. T. Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Perminder S. Sachdev, Cohort Studies of Memory in an International Consortium (COSMIC)

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002261

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O’Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty

PLOS Medicine: published March 21, 2017 | https://doi.org/10.1371/journal.pmed.1002266

Association between delirium superimposed on dementia and mortality in hospitalized older adults: A prospective cohort study

Thiago J. Avelino-Silva, Flavia Campora, Jose A. E. Curiati, Wilson Jacob-Filho

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002264

Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study

Sabrina Schilling, Christophe Tzourio, Aïcha Soumaré, Sara Kaffashian, Jean-François Dartigues, Marie-Laure Ancelin, Cécilia Samieri, Carole Dufouil, Stéphanie Debette

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002265

Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study

Claudia K. Suemoto, Renata E. L. Ferretti-Rebustini, Roberta D. Rodriguez, Renata E. P. Leite, Luciana Soterio, Sonia M. D. Brucki, Raphael R. Spera, Tarcila M. Cippiciani, Jose M. Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A. Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T. Grinberg

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002267

The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial

Martin Orrell, Lauren Yates, Phuong Leung, Sujin Kang, Zoe Hoare, Chris Whitaker, Alistair Burns, Martin Knapp, Iracema Leroi, Esme Moniz-Cook, Stephen Pearson, Stephen Simpson, Aimee Spector, Steven Roberts, Ian Russell, Hugo de Waal, Robert T. Woods, Vasiliki Orgeta

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002269

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

Hélène-Marie Lanoiselée, Gaël Nicolas, David Wallon, Anne Rovelet-Lecrux, Morgane Lacour, Stéphane Rousseau, Anne-Claire Richard, Florence Pasquier, Adeline Rollin-Sillaire, Olivier Martinaud, Muriel Quillard-Muraine, Vincent de la Sayette, Claire Boutoleau-Bretonniere, Frédérique Etcharry-Bouyx, Valérie Chauviré, Marie Sarazin, Isabelle le Ber, Stéphane Epelbaum, Thérèse Jonveaux, Olivier Rouaud, Mathieu Ceccaldi, Olivier Félician, Olivier Godefroy, Maite Formaglio, Bernard Croisile, Sophie Auriacombe, Ludivine Chamard, Jean-Louis Vincent, Mathilde Sauvée, Cecilia Marelli-Tosi, Audrey Gabelle, Canan Ozsancak, Jérémie Pariente, Claire Paquet, Didier Hannequin, Dominique Campion, collaborators of the CNR-MAJ project

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002270

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

Natasha Z. R. Steele, Jessie S. Carr, Luke W. Bonham, Ethan G. Geier, Vincent Damotte, Zachary A. Miller, Rahul S. Desikan, Kevin L. Boehme, Shubhabrata Mukherjee, Paul K. Crane, John S. K. Kauwe, Joel H. Kramer, Bruce L. Miller, Giovanni Coppola, Jill A. Hollenbach, Yadong Huang, Jennifer S. Yokoyama

PLOS Medicine: published March 28, 2017 | https://doi.org/10.1371/journal.pmed.1002272