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Table of Contents

May 2009

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Where the most private becomes public: Policy making for sexual health.
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In the editorial for the May issue the PLoS Medicine editors discuss how clinical research could help to promote better sexual health for all. From the growing burden of sexually transmitted infections to the unmet contraceptive needs of specific groups, sexual health problems are complex, as they sit at the intersection of health, culture, religion, and politics. The editorial draws particular attention to unmet contraceptive needs and unsafe sex, which both figure in the top 20 risk factors for mortality and burden of disease and have been included in PLoS Medicine's recently announced priority areas for publication. Key PLoS Medicine papers that highlight some of the varied themes in sexual health are also highlighted. The editorial concludes that "It is time to realign research and policy making to promote better sexual health for all."

Image Credit: Michael Massacre at flickr.com

Editorial

Where the Most Private Becomes Public: Policy Making for Sexual Health

The PLoS Medicine Editors

PLOS Medicine: published May 26, 2009 | https://doi.org/10.1371/journal.pmed.1000082

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  5. A Medical Journal for the World's Health Priorities

The PLoS Medicine Debate

Do Electronic Health Records Help or Hinder Medical Education?

Jonathan U. Peled, Oren Sagher, Jay B. Morrow, Alison E. Dobbie

PLOS Medicine: published May 12, 2009 | https://doi.org/10.1371/journal.pmed.1000069

Essays

No More Free Drug Samples?

Susan Chimonas, Jerome P. Kassirer

PLOS Medicine: published May 12, 2009 | https://doi.org/10.1371/journal.pmed.1000074

Surgical Task Shifting in Sub-Saharan Africa

Kathryn Chu, Peter Rosseel, Pierre Gielis, Nathan Ford

PLOS Medicine: published May 19, 2009 | https://doi.org/10.1371/journal.pmed.1000078

Preventing Bias in Cluster Randomised Trials

Bruno Giraudeau, Philippe Ravaud

PLOS Medicine: published May 5, 2009 | https://doi.org/10.1371/journal.pmed.1000065

Perspectives

Folic Acid Supplementation and Spontaneous Preterm Birth: Adding Grist to the Mill?

Leonie Callaway, Paul B. Colditz, Nicholas M. Fisk

PLOS Medicine: published May 12, 2009 | https://doi.org/10.1371/journal.pmed.1000077

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  2. Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

A New Tumor Suppressor That Regulates Tissue Architecture

Senthil K. Muthuswamy

PLOS Medicine: published May 5, 2009 | https://doi.org/10.1371/journal.pmed.1000073

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Policy Forum

Policy Coherence in US Tobacco Control: Beyond FDA Regulation

Joshua S. Yang, Thomas E. Novotny

PLOS Medicine: published May 19, 2009 | https://doi.org/10.1371/journal.pmed.1000079

Guidelines and Guidance

Evaluation and Recommendations on Good Clinical Laboratory Practice Guidelines for Phase I–III Clinical Trials

Marcella Sarzotti-Kelsoe, Josephine Cox, Naana Cleland, Thomas Denny, John Hural, Leila Needham, Daniel Ozaki, Isaac R. Rodriguez-Chavez, Gwynneth Stevens, Timothy Stiles, Tony Tarragona-Fiol, Anita Simkins

PLOS Medicine: published May 5, 2009 | https://doi.org/10.1371/journal.pmed.1000067

Research Articles

Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

Radek Bukowski, Fergal D. Malone, Flint T. Porter, David A. Nyberg, Christine H. Comstock, Gary D. V. Hankins, Keith Eddleman, Susan J. Gross, Lorraine Dugoff, Sabrina D. Craigo, Ilan E. Timor-Tritsch, Stephen R. Carr, Honor M. Wolfe, Mary E. D'Alton

PLOS Medicine: published May 12, 2009 | https://doi.org/10.1371/journal.pmed.1000061

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Hedging against Antiviral Resistance during the Next Influenza Pandemic Using Small Stockpiles of an Alternative Chemotherapy

Joseph T. Wu, Gabriel M. Leung, Marc Lipsitch, Ben S. Cooper, Steven Riley

PLOS Medicine: published May 19, 2009 | https://doi.org/10.1371/journal.pmed.1000085

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  1. Can We “Hedge” against the Development of Antiviral Resistance among Pandemic Influenza Viruses?

Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

Zitta B. Harboe, Reimar W. Thomsen, Anders Riis, Palle Valentiner-Branth, Jens Jørgen Christensen, Lotte Lambertsen, Karen A. Krogfelt, Helle B. Konradsen, Thomas L. Benfield

PLOS Medicine: published May 26, 2009 | https://doi.org/10.1371/journal.pmed.1000081

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S. Usmani, Ian M. Adcock, Peter J. Barnes

PLOS Medicine: published May 19, 2009 | https://doi.org/10.1371/journal.pmed.1000076

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  1. Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer

Steven T. Lott, Nanyue Chen, Dawn S. Chandler, Qifeng Yang, Luo Wang, Marivonne Rodriguez, Hongyan Xie, Seetharaman Balasenthil, Thomas A. Buchholz, Aysegul A. Sahin, Katrina Chaung, Baili Zhang, Shodimu-Emmanu Olufemi, Jinyun Chen, Henry Adams, Vimla Band, Adel K. El-Naggar, Marsha L. Frazier, Khandan Keyomarsi, Kelly K. Hunt, Subrata Sen, Bruce Haffty, Stephen M. Hewitt, Ralf Krahe, Ann McNeill Killary

PLOS Medicine: published May 5, 2009 | https://doi.org/10.1371/journal.pmed.1000068

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Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

Kevin J. Sonnemann, Hanke Heun-Johnson, Amy J. Turner, Kristen A. Baltgalvis, Dawn A. Lowe, James M. Ervasti

PLOS Medicine: published May 26, 2009 | https://doi.org/10.1371/journal.pmed.1000083