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Table of Contents

October 2005

Cover

Dementia.
Issue Image

Rob Frankle is an illustrator and graphic designer. In both disciplines, his goal is to communicate issues with simplicity and psychological impact. He believes that the process of painting is a dialogue between external and internal reality. From childhood, he has always been fascinated with how marks on paper can often reach below the surface of experience and connect with viewers. In this painting, Frankle focuses on the common yet not fully understood condition we call "dementia." The main symptom of dementia is an acute decline in mental ability. With this, an upheaval of personal reality occurs. One's normal construct of time and place often dissolves. Dementia dramatically reveals to us the critical nature of brain function in defining our reality.

Frankle holds a B. F. A. degree from The Cooper Union for the Advancement of Science and Art and resides in Brewster, New York.

Image Credit: Rob Frankle (www.robfrankle.com)

Editorial

Tackling Publication Bias in Clinical Trial Reporting

Emma Veitch, The PLoS Medicine Editors

PLOS Medicine: published October 18, 2005 | https://doi.org/10.1371/journal.pmed.0020367

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  3. Beyond Trial Registration: A Global Trial Bank for Clinical Trial Reporting
  4. Correction/Clarification about FDA Review Documents
  5. Unique Author Identification Number in Scientific Databases: A Suggestion
  6. Editor's Reply

Essays

Making Practical Markets for Vaccines

Donald W Light

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020271

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Introduction of New and Underutilized Vaccines: Sustaining Access, Disease Control, and Infrastructure Development

Jon Kim Andrus, John Fitzsimmons

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020286

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Free Antiretrovirals Must Not Be Restricted Only to Treatment-Naive Patients

Robert Colebunders, Moses Kamya, Fred Semitala, Barbara Castelnuovo, Elly Katabira, Keith McAdam

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020276

Perspectives

Pharmacogenetics in the Management of Coumarin Anticoagulant Therapy: The Way Forward or an Expensive Diversion?

Mike Greaves

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020342

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Does the CAPON Gene Confer Susceptibility to Schizophrenia?

Sharon L Eastwood

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020348

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The End of the Line for Hookworm? An Update on Vaccine Development

Eileen Devaney

PLOS Medicine: published October 4, 2005 | https://doi.org/10.1371/journal.pmed.0020327

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Cancer Vaccines: The Next Generation of Tools to Monitor the Anticancer Immune Response

Frank O Nestle, Giulia Tonel, Arpad Farkas

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020339

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Retinoblastoma: Teacher of Cancer Biology and Medicine

Alfred Knudson

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020349

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Policy Forums

An Immeasurable Crisis? A Criticism of the Millennium Development Goals and Why They Cannot Be Measured

Amir Attaran

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020318

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  3. Author's Reply

Achieving the Millennium Development Goals: Does Mental Health Play a Role?

J. Jaime Miranda, Vikram Patel

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020291

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Data Cleaning: Detecting, Diagnosing, and Editing Data Abnormalities

Jan Van den Broeck, Solveig Argeseanu Cunningham, Roger Eeckels, Kobus Herbst

PLOS Medicine: published September 6, 2005 | https://doi.org/10.1371/journal.pmed.0020267

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Research in Translation

Use of Preclinical Models to Improve Treatment of Retinoblastoma

Michael A Dyer, Carlos Rodriguez-Galindo, Matthew W Wilson

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020332

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Research Articles

Latitude, Birth Date, and Allergy

Matthias Wjst, Shyamali Dharmage, Elisabeth André, Dan Norback, Chantal Raherison, Simona Villani, Jure Manfreda, Jordi Sunyer, Deborah Jarvis, Peter Burney, Cecilie Svanes

PLOS Medicine: published October 4, 2005 | https://doi.org/10.1371/journal.pmed.0020294

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Impaired Cross-Modal Inhibition in Alzheimer Disease

Alexander Drzezga, Timo Grimmer, Martin Peller, Marc Wermke, Hartwig Siebner, Josef P Rauschecker, Markus Schwaiger, Alexander Kurz

PLOS Medicine: published September 20, 2005 | https://doi.org/10.1371/journal.pmed.0020288

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A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

Pieter H Reitsma, Jeroen F. van der Heijden, Angelique P Groot, Frits R Rosendaal, Harry R Büller

PLOS Medicine: published October 11, 2005 | https://doi.org/10.1371/journal.pmed.0020312

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  2. Understanding Bleeding Risk after Anticoagulation
  3. Mischievous Odds Ratios
  4. Authors' Reply

Increased Expression in Dorsolateral Prefrontal Cortex of CAPON in Schizophrenia and Bipolar Disorder

Bin Xu, Naomi Wratten, Erik I Charych, Steven Buyske, Bonnie L Firestein, Linda M Brzustowicz

PLOS Medicine: published September 13, 2005 | https://doi.org/10.1371/journal.pmed.0020263

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Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasite Load and Blood Loss after Hookworm Infection in Dogs

Alex Loukas, Jeffrey M Bethony, Susana Mendez, Ricardo T Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi, Peter J Hotez

PLOS Medicine: published October 4, 2005 | https://doi.org/10.1371/journal.pmed.0020295

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Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray

Daniel S Chen, Yoav Soen, Tor B Stuge, Peter P Lee, Jeffrey S Weber, Patrick O Brown, Mark M Davis

PLOS Medicine: published September 20, 2005 | https://doi.org/10.1371/journal.pmed.0020265

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Effects of ADMA upon Gene Expression: An Insight into the Pathophysiological Significance of Raised Plasma ADMA

Caroline L Smith, Shelagh Anthony, Mike Hubank, James M Leiper, Patrick Vallance

PLOS Medicine: published October 4, 2005 | https://doi.org/10.1371/journal.pmed.0020264

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Correspondence

The Tenofovir Pre-Exposure Prophylaxis Trial in Thailand: Researchers Should Show More Openness in Their Engagement with the Community

Arlene Chua, Nathan Ford, David Wilson, Paul Cawthorne

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020346

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Response to Joep M. A. Lange

Melissa Ditmore

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020347

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Layperson's View

Simone Autry

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020363

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We Must Find the Problem in the Intrinsic Mechanisms of Both Media and Medical Research

Luciano Benedetti

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020364

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The Focus of the Media Is Medical Intervention, Not the Pursuit of Health

Desmond A Gale

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020362

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Corrections

Correction: A Breakthrough in R&D for Neglected Diseases: New Ways to Get the Drugs We Need

Mary Moran

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020376

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Correction: The Incidence of Dementia in England and Wales: Findings from the Five Identical Sites of the MRC CFA Study

Fiona Matthews, Carol Brayne

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020389

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Correction: Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2

Arjen M Dondorp, Varunee Desakorn, Wirichada Pongtavornpinyo, Duangjai Sahassananda, Kamolrat Silamut, Kesinee Chotivanich, Paul N Newton, Punnee Pitisuttithum, A. M Smithyman, Nicholas J White, Nicholas P. J Day

PLOS Medicine: published October 25, 2005 | https://doi.org/10.1371/journal.pmed.0020390

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