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Osteoarthritis of the knee is an extremely common and debilitating condition that affects a significant proportion of the world’s population over the age of 40. A hallmark of the disease is pain and its effect on joint function. Resveratrol, a plant-derived compound, is currently available over-the-counter as an oral supplement in many countries. Existing data suggests that this could provide a promising new pharmacological treatment for people with knee osteoarthritis, but further trials are required to support its use. In this study, Christelle Nguyen and colleagues evaluate the effectiveness of a patented formulation of resveratrol in improving chronic pain levels by comparing it to placebo in a double-blind, randomized, Phase 3 clinical trial conducted in 3 tertiary care centres across France.
Image Credit: Towfiqu barbhuiya, Pexels
Citation: (2024) PLoS Medicine Issue Image | Vol. 21(8) September 2024. PLoS Med 21(8): ev21.i08. https://doi.org/10.1371/image.pmed.v21.i08
Published: September 4, 2024
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Osteoarthritis of the knee is an extremely common and debilitating condition that affects a significant proportion of the world’s population over the age of 40. A hallmark of the disease is pain and its effect on joint function. Resveratrol, a plant-derived compound, is currently available over-the-counter as an oral supplement in many countries. Existing data suggests that this could provide a promising new pharmacological treatment for people with knee osteoarthritis, but further trials are required to support its use. In this study, Christelle Nguyen and colleagues evaluate the effectiveness of a patented formulation of resveratrol in improving chronic pain levels by comparing it to placebo in a double-blind, randomized, Phase 3 clinical trial conducted in 3 tertiary care centres across France.
Image Credit: Towfiqu barbhuiya, Pexels