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PLoS Medicine Issue Image | Vol. 20(7) August 2023

The emergence of pathogenic bacteria that cannot be effectively treated with existing antimicrobials has been prioritised by the World Health Organization as one of the top ten global public health threats facing humanity. The burden of antimicrobial resistance (AMR) is disproportionately observed in low- and middle-income countries, particularly those in sub-Saharan Africa. Without intervention, it has been estimated that global deaths attributable to AMR could reach 10 million annually by 2050. Guest editors Timothy Walsh, Ramanan Laxminarayan, Ana Gales and PLOS Medicine editor, Philippa Dodd discuss the PLOS Medicine Special Issue dedicated to AMR. This collection of high-quality research articles defines the problem from a One Health perspective and highlights the multi-faceted challenges imposed by drug-resistant bacteria, the vast number of contributing factors, the consequences for health and economics, and interventions that could lessen the burden.

Image Credit: CDC, Unsplash

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The emergence of pathogenic bacteria that cannot be effectively treated with existing antimicrobials has been prioritised by the World Health Organization as one of the top ten global public health threats facing humanity. The burden of antimicrobial resistance (AMR) is disproportionately observed in low- and middle-income countries, particularly those in sub-Saharan Africa. Without intervention, it has been estimated that global deaths attributable to AMR could reach 10 million annually by 2050. Guest editors Timothy Walsh, Ramanan Laxminarayan, Ana Gales and PLOS Medicine editor, Philippa Dodd discuss the PLOS Medicine Special Issue dedicated to AMR. This collection of high-quality research articles defines the problem from a One Health perspective and highlights the multi-faceted challenges imposed by drug-resistant bacteria, the vast number of contributing factors, the consequences for health and economics, and interventions that could lessen the burden.

Image Credit: CDC, Unsplash

https://doi.org/10.1371/image.pmed.v20.i07.g001