Estimates indicate that, worldwide, approximately one million sexually transmitted infections occur each day, incurring an enormous burden of morbidity, mortality and further infections. The pathogens responsible include bacteria, parasites and viruses, and intensive research is needed to address the substantial barriers to diagnosis and treatment, and the behavioral challenges of prevention. In this month's Editorial, Nicola Low and coauthors announce a call for research papers addressing the prevention, diagnosis and treatment of sexually transmitted infections. Published alongside the Editorial are several discussion pieces forming part of a Collection addressing global policy and practice on sexually transmitted infections, sponsored by WHO.

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