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Open Access
Peer-reviewed
Research Article
Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis
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Zhuo-Ying Li,
Roles Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
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Hong-Lan Li,
Roles Data curation, Investigation, Project administration, Resources, Validation, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
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Jing Wang,
Roles Data curation, Methodology, Project administration, Resources, Validation, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
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Qiu-Ming Shen,
Roles Data curation, Project administration, Resources, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
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Yi-Xin Zou,
Roles Formal analysis, Resources, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China, School of Public Health, Fudan University, Shanghai, China
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Dan-Ni Yang,
Roles Formal analysis, Resources, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yu-Ting Tan,
Roles Data curation, Investigation, Project administration, Resources, Writing – review & editing
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
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Yong-Bing Xiang
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: ybxiang@shsci.org
Affiliations State Key Laboratory of System Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China, School of Public Health, Fudan University, Shanghai, China, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis
- Zhuo-Ying Li,
- Hong-Lan Li,
- Jing Wang,
- Qiu-Ming Shen,
- Yi-Xin Zou,
- Dan-Ni Yang,
- Yu-Ting Tan,
- Yong-Bing Xiang
- Published: February 2, 2026
- https://doi.org/10.1371/journal.pmed.1004910