Aldosterone synthase inhibitors for hypertension: A breakthrough facing barriers to adoption

Luke J. Laffin; Steven E. Nissen

doi:10.1371/journal.pmed.1004900

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Aldosterone synthase inhibitors for hypertension: A breakthrough facing barriers to adoption

Luke J. Laffin ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: laffinl@ccf.org

Affiliations Section of Preventive Cardiology and Rehabilitation, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America, Cleveland Clinic Coordinating Center for Clinical Research, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

https://orcid.org/0000-0002-3262-792X

⨯
Steven E. Nissen

Roles Conceptualization, Writing – review & editing

Affiliations Section of Preventive Cardiology and Rehabilitation, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America, Cleveland Clinic Coordinating Center for Clinical Research, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
⨯

Aldosterone synthase inhibitors for hypertension: A breakthrough facing barriers to adoption

Luke J. Laffin,
Steven E. Nissen

Published: February 9, 2026
https://doi.org/10.1371/journal.pmed.1004900

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Aldosterone
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Hypertension
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Antihypertensive drug therapy
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Antihypertensive drugs
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Resistant hypertension
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Cardiovascular therapy
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Receptor antagonist therapy
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